HomeGene Dmel\ena
| General Information | |||
|---|---|---|---|
| Symbol | Dmel\ena | Species | D. melanogaster |
| Name | enabled | Annotation symbol | CG15112 |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0000578 |
| Created / Updated | 2005-01-19/2005-01-19 | ||
| Genomic Location | |||
| Chromosome (arm) | 2R | Recombination map | 2-87 |
| Cytogenetic map | 56B5-56C1 | Sequence location | 2R:15,029,140..15,050,124 [+] |
| Map ( GBrowse ) | 
| ||
Summary Information
| |||
|
Automatically generated summary
See sections below for more information | The gene enabled is referred to in FlyBase by the symbol ena (CG15112, FBgn0000578). It has the cytological map location 56B5-56C1. Its sequence location is 2R:15029140..15050124. Its molecular function is described as actin binding. It is involved in the biological processes: dendrite morphogenesis; axon guidance; axonogenesis; actin filament organization; regulation of cell shape; cytoskeleton organization and biogenesis; dorsal closure; regulation of actin polymerization and/or depolymerization; intracellular transport. 48 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: nervous system; organ system; anatomical structure; embryonic nervous system; peripheral nervous system; embryonic neuron; axon; embryonic central nervous system; commissure; adult segment. It has 6 annotated transcripts and 6 annotated polypeptides. | ||
| External Summaries | |||
|
Detailed Mapping Data
| |||
| FlyBase Computed Cytological Location | |||
Cytogenetic map Evidence for location 56B5-56C1
Limits computationally determined from genome sequence between P{lacW}prodk08810 and P{PZ}ena02029&P{lacW}corak08713
| |||
| Experimentally Determined Cytological Location | |||
Cytogenetic map Notes References 55F-56C Determined by deficiency mapping (details unspecified).
56C1-56C2 (determined by in situ hybridisation)
56C1-56C2 | |||
| Experimentally Determined Recombination Data | |||
| Location | 2-87 | ||
| Left of (cM) | |||
| Right of (cM) | |||
| Notes | |||
| Molecular Map Data | |||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References | |||
|
Gene Model & Products
| |||
Please see the
GBrowse view of
Dmel\ena
for information on other features
| |||
| Comments on Gene Model | |||
|
Transcript Data
| |||
| Annotated Transcripts | |||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0100174
2866
687 FBtr0100176
3463
684 FBtr0114623
4132
980 | |||
| Additional Transcript Data & Comments | |||
| Reported size (kB) | 3.4 (longest cDNA) | ||
| Comments | |||
| External Data | |||
| Crossreferences | |||
|
Polypeptide Data
| |||
| Annotated Polypeptides | |||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0099530
72.3
687
9.73
FBpp0099532
72.0
684
9.65
FBpp0113115
104.8
980
9.89
| |||
| Additional Polypeptide Data & Comments | |||
| Reported size (kD) | 684 (aa); 80 (kD observed); 72 (kD predicted) | ||
| Comments | |||
| External Data | |||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
| ||
| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Ran Binding Protein 1 (IPR000156)
EVH1 (IPR000697)
Pleckstrin homology-type (IPR011993)
VASP tetramerisation (IPR014885)
| ||
|
Sequences Consistent with the Gene Model
| |||
| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | ||
| UniProtKB/Swiss-Prot | |||
| UniProtKB/TrEMBL | |||
| Maps to | |||
| Does NOT map to | |||
| Identified with | |||
|
Mapped Features & Mutations
| |||
Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References point mutation ena[210] 2R:15,046,523..15,046,523 evidence=experimental pr_change=A97V na_change=C15046523T point mutation ena[23] 2R:15,048,918..15,048,918 comment=An additional amino acid change at or near amino acid residue 379 is also observed in ena[23]. evidence=experimental pr_change=K636@ na_change=A15048918T | |||
|
External Data
| |||
| Linkouts | DEDB
- Drosophila exon database: splicing graphs
| ||
| Crossreferences | |||
|
Expression Data
| |||
| FlyBase-Curated Data | |||
|
Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||
|
Summary of Transcript Expression
| |||
Stage Tissue/Position
Reference
| |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | |||
|
Summary of Polypeptide Expression
| |||
Stage Tissue/Position
Reference
embryonic stage | stage 10,11
endoderm
oogenesis stage
follicle cell
larval stage
photoreceptor cell
larval stage
rhabdomere
embryonic stage
embryonic central nervous system | restricted
embryonic stage | stage 8-11
embryonic stage | stage 12-14
embryonic central nervous system | presumptive
embryonic stage | stage 15,16
ventral nerve cord commissure
embryonic stage
embryonic hindgut
embryonic stage
embryonic leading edge cell
embryonic stage | stage 15-17
longitudinal connectives
embryonic stage
axon
embryonic stage
segment boundary
larval stage
adepithelial cell
larval stage
imaginal disc | restricted | |||
| Marker for | |||
| Subcellular Localization | |||
| CV Term | axon | ||
|
Microarray Data
|
|||
|
Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
| |||
|
External Data & Images
| |||
| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
FlyExpress
- Embryonic expression images (BDGP data)
| ||
|
Alleles & Phenotypes
| |||
|
Summary of Allele Phenotypes
| |||
Lethality Allele Other Phenotypes Allele Phenotype manifest in Allele commissure (with enaGC1) stage 14 embryo (with enaGC1) follicle cell & actin filament | somatic clone dendrite & embryo | dorsal | |||
Stage(s)
1-3
Stage(s)
7-8
Stage(s)
13-16