HomeGene Dmel\Eip75B
| General Information | ||||
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| Symbol | Dmel\Eip75B | Species | D. melanogaster | |
| Name | Ecdysone-induced protein 75B | Annotation symbol | CG8127 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0000568 | |
| Created / Updated | 2003-12-01/2003-12-01 | |||
| Genomic Location | ||||
| Chromosome (arm) | 3L | Recombination map | 3- | |
| Cytogenetic map | 75A10-75B6 | Sequence location | 3L:17,945,063..18,052,698 [-] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Ecdysone-induced protein 75B is referred to in FlyBase by the symbol Eip75B (CG8127, FBgn0000568). It has the cytological map location 75A10-75B6. Its sequence location is 3L:17945063..18052698. Its molecular function is described as: ligand-dependent nuclear receptor activity; specific RNA polymerase II transcription factor activity; steroid hormone receptor activity; zinc ion binding; sequence-specific DNA binding; transcription factor activity. It is involved in the biological processes: ecdysone-mediated induction of salivary gland cell autophagic cell death; ecdysis, chitin-based cuticle; molting cycle, chitin-based cuticle; regulation of ecdysteroid metabolic process; antimicrobial humoral response; regulation of transcription, DNA-dependent; oogenesis. 117 alleles are reported. The phenotypes of these alleles are annotated with: eye; egg; follicle cell; oocyte; germ cell; midgut constriction 1; midgut chamber 3; larval anterior spiracle; mouth hooks. It has 4 annotated transcripts and 4 annotated polypeptides. | |||
| External Summaries | ||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | E75 (W.A. Segraves)
Encodes an ecdysone-inducible gene associated with
the early puff at polytene position 75B. Periodic expression
occurs in response to ecdysone pulses occurring at specific
times during development; regression of puff and reduction of
E75 expression in third instar does not occur in the presence
of cycloheximide, and presumably depends on ecdysone-induced
gene products.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 75A10-75B6
Limits computationally determined from genome sequence between P{lacW}l(3)j11B2j11B2 and P{PZ}W05014
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 75B1-75B2 (determined by in situ hybridisation)
75B1-75B2 75B1--4 75B1--7 75B3--5 75B6--7
75B-75B (determined by in situ hybridisation)
75A6-75B13 (determined by in situ hybridisation)
75B-75B (determined by in situ hybridisation)
75B-75B (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 3- | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References Gene Order (overall orientation not stated) References Overall orientation not stated: Eip75B+ CG32192- Eip75B+ | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Eip75B
for information on other features
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| Comments on Gene Model | ||||
DGC clone GH02640 appears problematic: incomplete CDS The 3' end of the Eip75B CDSs predicted from the reference sequence differs from that of the CDs predicted from the published Eip75B sequences due to seqeunce differences which lead to frameshifts. Two sites of polyadenylation have been reported by Eip75B (see GB:X51548, GB:X51549, and GB:15586). Transposon inserted in intron | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | 6, 5.7, 5.2, 4.9 (northern blot) | |||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | 1394, 1237 (aa); 151, 132 (kD predicted) | |||
| Comments | One of a couple of protein products. | |||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Vitamin D receptor (IPR000324)
Nuclear hormone receptor, ligand-binding, core (IPR000536)
Zinc finger, nuclear hormone receptor-type (IPR001628)
Steroid hormone receptor (IPR001723)
Nuclear receptor ROR (IPR003079)
Nuclear hormone receptor, ligand-binding (IPR008946)
Zinc finger, NHR/GATA-type (IPR013088)
TRANSFAC
- Eukaryotic transcription factors, their genomic binding sites, and DNA-binding profiles
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | |||