A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\dx

General Information
SymbolDmel\dxSpeciesD. melanogaster
NamedeltexAnnotation symbolCG3929
Feature typeprotein_coding_geneFlyBase IDFBgn0000524
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)XRecombination map1-17.0
Cytogenetic map6B1-6B2Sequence locationX:6,428,043..6,432,615 [+]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene deltex is referred to in FlyBase by the symbol dx (CG3929, FBgn0000524). It has the cytological map location 6B1-6B2. Its sequence location is X:6428043..6432615. Its molecular function is described as: SH3 domain binding; protein binding; Notch binding; transporter activity; zinc ion binding. It is involved in the biological processes: Notch signaling pathway; regulation of Notch signaling pathway; negative regulation of Notch signaling pathway; positive regulation of Notch signaling pathway; Wnt receptor signaling pathway; transport. 29 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; adult mesothoracic segment; thoracic segment; tormogen cell; organ system; adult; dorsal thoracic disc; embryonic nervous system; acrostichal bristle. It has one annotated transcript and one annotated polypeptide.

External Summaries

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
dx: deltex
Veins show thickenings and terminal deltas; resembles Dl in third chromosomes except fully viable, fertile, and easily classified. Nearly suppressed by su(dx), Su(dx), and Su(dx)2. RK2.
dxst: deltex-sterile
Veins heavy, confluent, and dilated at junctions; strong deltas at tips. Wings spread wide; margins and tips snipped and nicked. Ocelli sometimes fused with disturbance of hairs and bristles in the region. Acrostichals irregular. Male sterile. Less abnormal phenotype and fertile with Su(dx). RK2.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
6B1-6B2  
Limits computationally determined from genome sequence between P{EP}EP1402&P{EP}CG15893EP1634 and P{EP}Ctr1AEP1364&P{EP}EP1445  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
6A-6A
(determined by in situ hybridisation)  
(Busseau, 1990)
6A-6A
(determined by in situ hybridisation)  
(Busseau et al., 1994)
Experimentally Determined Recombination Data
Location
1-17.0
 
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\dx for information on other features
detailed view FBtr0070917 FBtr0070916 FBtr0070915 FBtr0070914 FBpp0070877 FBpp0070879 FBpp0070878 FBpp0070876 FBti0041594
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
dx-RA
FBtr0070914
 NM_078509
  3824
  738
Additional Transcript Data & Comments
Reported size (kB)
4 (northern blot)
(Busseau et al., 1994)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
dx-PA  
FBpp0070876  
82.2  
738  
9.28  
  NP_511064
  AAF46170
Additional Polypeptide Data & Comments
Reported size (kD)
737 (aa); 80 (kD observed)
(Busseau et al., 1994)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
Major intrinsic protein (IPR000425)
Zinc finger, RING-type (IPR001841)
WWE (IPR004170)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AA816661
 
AE003437
AAF46170
 
AI544306
 
AY863438
 
AY863439
 
AY863440
 
AY863441
 
AY863442
 
AY863443
 
AY863444
 
AY863445
 
AY863446
 
AY863447
 
AY863448
 
AY863449
 
AY863450
 
AY863451
 
AY863452
 
AY863453
 
AY863454
 
AY863455
 
AY863456
 
AY863457
 
AY863458
 
AY863459
 
AY863460
 
AY863461
 
BI172374
 
BI216085
 
BI216582
 
BI227869
 
BI238103
 
BI372398
 
BI486615
 
BI574249
 
BI587329
 
BI604275
 
BI608182
 
BI611877
 
BI612837
 
BI616230
 
BI620507
 
BI622527
 
BT003476
AAO39479
 
CO190676
 
CO266584
 
CO279472
 
CO283219
 
CO302022
 
CO313223
 
CO313387
 
CO317934
 
CO319657
 
CO321440
 
CO322906
 
CO325639
 
CO338947
 
DN154059
 
EC058034
 
EC058201
 
EC082794
 
EC084495
 
EC089626
 
EC210827
 
EC223242
 
EC227675
 
EC243135
 
EC246438
 
EC246905
 
EC248481
 
EC250357
 
EC259965
 
U09789
AAA18501
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
     adult stage | female
     
    (Busseau et al., 1994)
     embryonic stage-pupal stage
     
    (Busseau et al., 1994)
     embryonic stage | early
     
    (Busseau et al., 1994)
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        cytoplasm
        (Busseau et al., 1994)
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0070917 FBtr0070916 FBtr0070915 FBtr0070914
        AI544306
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        viable
        lethal | maternal effect | recessive
        Other Phenotypes
        Allele
        visible
        visible | recessive
        visible | dominant
        visible, with Scer\GAL4ptc-559.1
        increased cell number | somatic clone, with Scer\GAL4αTub84B.PP
        flightless | recessive
        flightless | recessive | conditional - heat sensitive
        Sterility
        Allele
        male sterile
        Phenotype manifest in
        Allele
        wing | distal, with Scer\GAL4ptc-559.1
        wing margin, with Scer\GAL4ptc-559.1
        wing
        wing vein
        eye
        ocellus
        ommatidium
        thorax & macrochaeta
        wing | distal
        microchaeta
        anterior crossvein, with Scer\GAL4ptc-559.1
        wing margin | ectopic, with Scer\GAL4ptc-559.1
        wing margin bristle | ectopic, with Scer\GAL4ptc-559.1
        sensory mother cell | ectopic, with Scer\GAL4ptc-559.1
        dorsal mesothoracic disc | ventral, with Scer\GAL4ptc-559.1
        macrochaeta
        trichogen cell
        tormogen cell | ectopic
        socket | ectopic
        socket
        thecogen cell | ectopic
        eo neuron
        ocellar bristle
        acrostichal bristle
        hide Classical Alleles ( 10 )
        For All Classical Alleles Show

        Allele of dxClassMutagenStocksKnown lesion
        dx1loss of function4 --
        dx24loss of function
          		0 Yes
          dxDloss of function
            		0 --
            dxENU0 --
            dxP0 Yes
            dxS1M0 --
            dxeAN1loss of function0 --
            dxfl0 --
            dxst2 --
            dxunspecified
              		0 --
              hide Alleles Carried on Transgenic Constructs ( 19 )
              For All Alleles Carried on Transgenic Constructs Show

              Allele of dxClassMutagenStocksKnown lesion
              dx1-303.hs0 Yes
              dxGD14271 Yes
              dxGMR.PH0 Yes
              dxMtnA.PD0 Yes
              dxScer\UAS.T:Avic\GFP-YFP0 Yes
              dxScer\UAS.T:Sjap\GST0 Yes
              dxScer\UAS.cMa0 --
              dxTX00 Yes
              dxhs.PB0 Yes
              dxmRZF.Scer\UAS.T:Sjap\GST0 Yes
              dxmRZF.Scer\UAS0 Yes
              dxsev.PM0 Yes
              dxΔNBS.Scer\UAS.T:Sjap\GST0 Yes
              dxΔNBS.Scer\UAS0 Yes
              dxΔNBS.mRZF.Scer\UAS.T:Sjap\GST0 Yes
              dxΔNBS.mRZF.Scer\UAS0 Yes
              dxΔNBS.ΔPRM.Scer\UAS0 Yes
              dxΔPRM.Scer\UAS.T:Sjap\GST0 Yes
              dxΔPRM.Scer\UAS0 Yes
              hide Aneuploid Aberrations
              Useful deficiency
               
              Useful duplication
               
              Duplicated in
              (Dobzhansky, 1932)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Florence, 1999.7.22)
              (Busseau et al., 1994)
              Not duplicated in
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
              (Dobzhansky, 1932)
               
              Disrupted in
              (Florence, 1999.7.22)
              hide Transgenic Constructs & Insertions
              Transgenic Constructs
              Type of construct
              Name
              Expression data
              UAS construct
              P{GD1427}
              NA
              P{UAS-DxA89}
              NA
              P{UAS-dx.GST}
              NA
              P{UAS-dx.mRZF.GST}
              NA
              P{UAS-dx.mRZF}
              NA
              P{UAS-dx.ΔNBS.GST}
              NA
              P{UAS-dx.ΔNBS.mRZF.GST}
              NA
              P{UAS-dx.ΔNBS.mRZF}
              NA
              P{UAS-dx.ΔNBS.ΔPRM}
              NA
              P{UAS-dx.ΔNBS}
              NA
              P{UAS-dx.ΔPRM.GST}
              NA
              P{UAS-dx.ΔPRM}
              NA
              characterization construct
              P{GMR-dx.H}
              NA
              P{TX0}
              NA
              P{sev-dx.M}
              NA
              heat-shock construct
              P{Hsp70-dx1-303}
              NA
              P{Hsp70-dx}
              NA
              Insertions
              Type of insertions
              Name
              Expression data
              miscellaneous insertions
              P{}dxP
              NA
              hide Related Comments
              Please look at the allele reports for the complete phenotype data
              dx mutations are associated with a maternal embryo effect.
              (Xu and Artavanis-Tsakonas, 1990)
              Genetic interaction analysis suggests a three-way interaction between Su(dx), dx and N.
              (Busseau et al., 1994)
              Mutations at dx share phenotypes with mutations at sno, and genetic interactions indicate that sno, dx and N function in common pathways.
              (Coyle-Thompson and Banerjee, 1993)
              Su(H) shows allele specific interactions with N, Dl, dx and mam.
              (Fortini and Artavanis-Tsakonas, 1994)
              Mutations can act as dominant modifiers of the activated N eye phenotype (FBrf0064452).
              (Verheyen et al., 1995)
              Mutations (unspecified) enhance the rough eye phenotype of SerTM.sev.T:VSV\G and DlTM.sev flies.
              (Sun and Artavanis-Tsakonas, 1996)
              hide Gene Ontology: Function, Process & Cellular Component ( 13 )
              hide Molecular Function
              CV term
              Evidence
              References
              Notch binding
              traceable author statement
              (Martinez Arias, 2002)
              SH3 domain binding
              inferred from sequence or structural similarity
              (Matsuno and Artavanis-Tsakonas, 1995)
              protein binding
              inferred from sequence or structural similarity
              (Matsuno and Artavanis-Tsakonas, 1995)
              inferred from physical interaction with FLYBASE:N; FB:FBgn0004647
              (Matsuno et al., 2002)
              transporter activity
              inferred from electronic annotation with InterPro:IPR000425
              (FlyBase Curators et al., 2004-)
              zinc ion binding
              inferred from electronic annotation with InterPro:IPR001841
              (FlyBase Curators et al., 2004-)
              hide Biological Process
              CV term
              Evidence
              References
              Notch signaling pathway
              inferred from genetic interaction with FLYBASE:N; FB:FBgn0004647
              (Gorman and Girton, 1992)
              inferred from physical interaction with FLYBASE:N; FB:FBgn0004647
              (Diederich et al., 1994)
              inferred from genetic interaction with FLYBASE:Dl; FB:FBgn0000463 AND inferred from genetic interaction with FLYBASE:H; FB:FBgn0001169 AND inferred from genetic interaction with FLYBASE:Su(H); FB:FBgn0004837 AND inferred from genetic interaction with FLYBASE:mam; FB:FBgn0002643 AND inferred from genetic interaction with FLYBASE:sno; FB:FBgn0005410
              (Matsuno and Artavanis-Tsakonas, 1995)
              traceable author statement
              (Martinez Arias, 2002)
              Wnt receptor signaling pathway
              inferred from mutant phenotype
              (Ramain et al., 2001)
              negative regulation of Notch signaling pathway
              inferred from direct assay
              (Matsuno et al., 1995)
              inferred from direct assay
              (Matsuno et al., 2002)
              positive regulation of Notch signaling pathway
              inferred from direct assay
              (Matsuno et al., 1995)
              inferred from direct assay
              (Matsuno et al., 2002)
              traceable author statement
              (Kadesch, 2000)
              regulation o