Gene Dmel\csw

General Information
Symbol	Dmel\csw	Species	D. melanogaster
Name	corkscrew	Annotation symbol	CG3954
Feature type	protein_coding_gene	FlyBase ID	FBgn0000382
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	X	Recombination map	1-1
Cytogenetic map	2D1-2D2	Sequence location	X:1,988,269..2,007,698 [+]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene corkscrew is referred to in FlyBase by the symbol csw (CG3954, FBgn0000382). It has the cytological map location 2D1-2D2. Its sequence location is X:1988269..2007698. Its molecular function is described as: non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein binding; receptor signaling protein tyrosine phosphatase activity. It is involved in the biological processes described with 16 unique terms, many of which group under: anatomical structure development; open tracheal system development; anterior/posterior axis specification; transmembrane receptor protein tyrosine kinase signaling pathway; tripartite regional subdivision; sensory organ development; regulation of compound eye photoreceptor development; biopolymer modification; central nervous system development; protein modification process; establishment and/or maintenance of polarity of follicular epithelium. 47 alleles are reported. The phenotypes of these alleles are annotated with 39 unique terms, many of which group under: organ system; peripheral nervous system; nervous system; adult segment; adult mesothoracic segment; primordium; thoracic segment; embryonic/larval tracheal system; tracheal system; portion of tissue; appendage segment. It has 3 annotated transcripts and 3 annotated polypeptides.
External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	csw: corkscrew Hemizygotes die at the larval-pupal transition; dissected third-instar larvae display small imaginal disks. Larval neuroblast cells show low mitotic index, but chromosome morphology appears normal. Homozygous germ-line clones produce inviable embryos with U-shaped or twisted phenotypes, which are unaffected by paternal genotype or developmental temperature. csw6 is viable and fertile with rough eyes.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2D1-2D2 Limits computationally determined from genome sequence between P{EP}Actn^EP1193&P{EP}CG4322^EP1631 and P{EP}EP1460&P{EP}CG2924^EP1596
Experimentally Determined Cytological Location
Cytogenetic map Notes References 2D1-2D2 (determined by in situ hybridisation) 2C7--D2 (determined by in situ hybridisation) (Peter et al., 2002) 2D1-2D1 (determined by in situ hybridisation) (Schaefer et al., 1999.3.29)
Experimentally Determined Recombination Data
Location	1-1 (Simon et al., 1991)
Left of (cM)
Right of (cM)
Notes	csw^Esev1A-eOP maps 1 map unit from the telomere of the X chromosome. (Allard et al., 1996)
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\csw for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) csw-RA FBtr0070378 NM_057782 4558 841 csw-RB FBtr0070379 NM_057783 4769 945 csw-RC FBtr0070380 NM_166928 4107 682
Additional Transcript Data & Comments
Reported size (kB)	7.2, 6.0, 4.7 (northern blot) (Perkins et al., 1992)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein csw-PA FBpp0070362 92.4 841 8.46 NP_477130 AAF45724 csw-PB FBpp0070363 103.8 945 9.47 NP_477131 AAF45725 csw-PC FBpp0070364 74.5 682 8.66 NP_726793 AAG22389
Additional Polypeptide Data & Comments
Reported size (kD)	841 (aa); 92.4 (kD) (Perkins et al., 1992)
Comments	One of a couple of products generated by alternative splicing. (FlyBase, 1992-, FlyBase, 1992-)
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0000382
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein-tyrosine phosphatase, receptor/non-receptor type (IPR000242) Protein-tyrosine phosphatase (IPR000387) SH2 motif (IPR000980) Protein-tyrosine phosphatase, active site (IPR016130)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140678 AA202431 AA263479 AA264256 AA697809 AA817429 AA940725 AE003423 AAF45724 AE003423 AAF45725 AE003423 AAG22389 AI135727 AI297926 AI455301 AL132797 CAB65870 AL132797 CAB65871 AX777353 AX777355 AX777365 AY135117 AAN17607 AY135117 AAN17608 AY135118 AAN17609 AY135118 AAN17610 AY135119 AAN17611 AY135119 AAN17612 AY135120 AAN17613 AY135120 AAN17614 AY135121 AAN17615 AY135121 AAN17616 AY135122 AAN17617 AY135122 AAN17618 AY135123 AAN17619 AY135123 AAN17620 AY135124 AAN17621 AY135124 AAN17622 AY135125 AAN17623 AY135125 AAN17624 AY135126 AAN17625 AY135126 AAN17626 AY135127 AAN17627 AY135127 AAN17628 AY135128 AAN17629 AY135128 AAN17630 AY135129 AAN17631 AY135129 AAN17632 AY135130 AAN17633 AY135130 AAN17634 AY135131 AAN17635 AY135131 AAN17636 AY135132 AAN17637 AY135132 AAN17638 AY135133 AAN17639 AY135133 AAN17640 AY135134 AAN17641 AY135134 AAN17642 BI163603 BI166183 BI230047 BI233182 BI234334 BI236303 BI237089 BI371972 BI371983 BI567038 BI585230 BI588148 BI588364 BI606153 BP542662 BP543853 BP543854 BP545551 BP545552 BP548082 BT001484 AAN71239 BT024248 CO177004 CO177382 CO178565 CO181731 CO186445 CO190138 CO276484 CO276878 CO277380 CO282760 CO284754 CO284992 CO286278 CO308111 CO308676 CO323744 CO324342 CO325081 CO327243 CO327661 CO329447 CO329982 CZ482308 CZ482309 CZ485477 CZ489219 EC051075 EC051589 EC054591 EC055131 EC056605 EC058315 EC060187 EC062891 EC063202 EC066926 EC068020 EC069189 EC069679 EC069986 EC071479 EC076467 EC081378 EC194800 EC203969 EC206926 EC208886 EC211174 EC211557 EC217673 EC222525 EC223870 EC227774 EC230115 EC232263 EC238136 EC241562 EC242149 EC247060 EC249401 EC260194 EC260249 EL884384 EL884498 M94730 AAA28433 U19909 AAB02543 U19909 AAB02544

UniProtKB/Swiss-Prot	P29349
UniProtKB/TrEMBL

Maps to	BACN25G24 (FlyBase, 1992-)
Does NOT map to
Identified with	HL03192 (Benos et al., 2001) LD22829 (White et al., 1999, BDGP Project Members, 2000-) D1012 (BDGP Project Members, 1994-1999)
Mapped Features & Mutations
Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here Type Symbol & Location Additional Notes References point mutation csw[Esev1A-eOP] X:2,004,611..2,004,611 evidence=experimental pr_change=G547E na_change=G2004611A (Allard et al., 1996)
External Data
Linkouts	DEDB - Drosophila exon database: splicing graphs • 306
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference embryonic stage \| late (Perkins et al., 1992) embryonic stage \| late (Perkins et al., 1992) larval stage-adult stage (Perkins et al., 1992) larval stage-adult stage (Perkins et al., 1992) embryonic stage (Perkins et al., 1992)
Marker for

Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for

Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000382 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • FBgn0000382 GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies • FBgn0000382
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable csw¹³ lethal \| maternal effect csw^KN27 lethal \| recessive csw^13-87 csw¹ csw⁵ csw⁶⁶⁷ csw⁶ csw⁷ csw⁸¹⁷ csw^Esev1A-3EC csw^Esev1A-eOP csw^G0170 lethal \| germ-line clone csw^Esev1A-eOP lethal \| germ-line clone \| maternal effect csw¹ lethal \| embryonic stage \| maternal effect \| recessive csw^lf lethal \| embryonic stage \| germ-line clone \| rescuable maternal effect csw^13-87 csw¹ csw⁵ csw⁶ csw⁷ csw^LE120 csw^e13d.3 lethal \| larval stage csw^G0171 lethal \| pupal stage csw^13-87 csw¹ csw⁵ csw⁶ csw⁷ csw^G0170 csw^e13d.3 lethal \| pupal stage \| recessive csw^13-87 csw¹ csw⁵ csw⁶ csw⁷ csw^Esev1A-eOP csw^KN27 csw^LE120 csw^e13d.3 Other Phenotypes Allele wild-type csw^+mLa csw^{R137K.hs.2sev} csw^R32K.hs.2sev csw^hs.2sev csw^hs.PP csw^Δin.hs.2sev csw^{Δtail.hs.2sev} visible csw^CS.hs.2sev csw^{SH2SH2.hs.2sev} csw^lf visible \| recessive \| conditional - heat sensitive csw^lf visible \| dominant csw^CS.hs.2sev csw^Esev1A-eOP csw^{G547E.hs.2sev} cell death increase csw¹ csw^CS.hs.2sev Phenotype manifest in Allele embryo \| germ-line clone \| maternal effect csw¹ eye disc csw¹ csw^CS.hs.2sev embryonic head \| germ-line clone \| maternal effect csw¹ embryonic/first instar larval cuticle \| germ-line clone csw^13-87 csw⁵ csw⁶ csw⁷ csw^e13d.3 amnioproctodeal invagination csw⁵ Malpighian tubule primordium csw⁵ neurogenic region csw⁵ csw⁶ csw^LE120 commissure \| germ-line clone csw⁵ longitudinal connective \| germ-line clone csw⁵ tracheal precursor cell \| germ-line clone csw⁵ csw⁶ arista csw⁵ csw^LE120 unguis csw⁵ csw^LE120 tarsal segment csw⁵ csw^LE120 wing vein L5 csw⁵ csw^LE120 ommatidium csw⁵ csw^CS.hs.2sev csw^{G547E.hs.2sev} csw^LE120 interommatidial bristle