HomeGene Dmel\crc
| General Information | ||||
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| Symbol | Dmel\crc | Species | D. melanogaster | |
| Name | cryptocephal | Annotation symbol | CG8669 | |
| Feature type | protein_coding_gene | FlyBase ID | FBgn0000370 | |
| Created / Updated | 2005-09-09/2005-09-09 | |||
| Genomic Location | ||||
| Chromosome (arm) | 2L | Recombination map | 2-55 +/- 1 | |
| Cytogenetic map | 39C2-39C3 | Sequence location | 2L:21,310,854..21,319,536 [+] | |
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene cryptocephal is referred to in FlyBase by the symbol crc (CG8669, FBgn0000370). It has the cytological map location 39C2-39C3. Its sequence location is 2L:21310854..21319536. Its molecular function is described as: transcription factor activity; protein heterodimerization activity; sequence-specific DNA binding; protein dimerization activity. It is involved in the biological processes: molting cycle, chitin-based cuticle; pupariation; pupation; regulation of transcription; metamorphosis; regulation of transcription, DNA-dependent. 15 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: adult segment; thoracic segment; anatomical structure; adult; organ system; adult mesothoracic segment; larval thorax; dorsal thoracic disc; imaginal precursor; adult cuticle; cephalopharyngeal skeleton; spiracle. It has 3 annotated transcripts and 3 annotated polypeptides. | |||
| External Summaries | ||||
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Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
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| Gene/Allele symbols may differ from current usage | crc: cryptocephal
Homozygotes frequently die as larvae; failure to
eliminate chitinous mouthparts at the larval molt frequently
results in larvae with suspernumerary mouth parts; homozygotes
undergo pupation but rarely eclose from puparia. Imaginal
head is not everted from thorax. Except for slightly reduced
eyes and shortened legs, wings, and thoracic bristles, the
head and thorax are fully differentiated; frequently fail to
pass gas bubble to anterior retro-opercular position, thus
failing to provide space for head eversion. Head eversion is
inhibited by integument being more rigid than normal. Mutant
integument contains more glucosamine than normal; Sparrow and
Chaddfield unable to confirm (1982, Dev. Genet. 3: 235-45).
Feeding glucosamine to wild-type larvae produces a phenocopy
very similar to l(2)crc. Abdomen often shows no differentiation, and internal organ development is arrested at pupal
stage. Lethality suppressed by su(crc)1 (Sparrow, 1981,
Genet. Res. 38: 297-314). RK3.
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | ||||
Cytogenetic map Evidence for location 39C2-39C3
Limits computationally determined from genome sequence between P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106 and P{PZ}l(2)05095a05095a
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| Experimentally Determined Cytological Location | ||||
Cytogenetic map Notes References 39C4-39C4 (determined by in situ hybridisation)
39C2-39C4 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | ||||
| Location | 2-55 +/- 1 | |||
| Left of (cM) | ||||
| Right of (cM) | ||||
| Notes | ||||
| Molecular Map Data | ||||
Gene Order (in direction of increasing cytology)
References In direction of increasing cytology: l(2)k05106- crc+ Gene Order (overall orientation not stated) References | ||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\crc
for information on other features
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| Comments on Gene Model | ||||
EST data support existence of multiple transcripts due to variable use of 5' exons | ||||
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Transcript Data
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| Annotated Transcripts | ||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0100139
1196
105 | ||||
| Additional Transcript Data & Comments | ||||
| Reported size (kB) | ||||
| Comments | ||||
| External Data | ||||
| Crossreferences | ||||
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Polypeptide Data
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| Annotated Polypeptides | ||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0099487
12.0
105
3.49
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| Additional Polypeptide Data & Comments | ||||
| Reported size (kD) | ||||
| Comments | ||||
| External Data | ||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Basic-leucine zipper (bZIP) transcription factor (IPR004827)
bZIP transcription factor, bZIP-1 (IPR011616)
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Sequences Consistent with the Gene Model
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| DDBJ
/
EMBL / GenBank | DNA sequence Protein sequence Name | |||