A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\cort

General Information
SymbolDmel\cortSpeciesD. melanogaster
NamecortexAnnotation symbolCG11330
Feature typeprotein_coding_geneFlyBase IDFBgn0000351
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)2LRecombination map2-49
Cytogenetic map26F6-26F6Sequence location2L:6,674,637..6,676,635 [-]
Map ( GBrowse ) detailed view
hide Summary Information
Automatically generated summary

See sections below for more information
The gene cortex is referred to in FlyBase by the symbol cort (CG11330, FBgn0000351). It has the cytological map location 26F6. Its sequence location is 2L:6674637..6676635. Its molecular function is unknown. It is involved in the biological processes: cellularization; pole cell formation; female meiosis; homologous chromosome segregation; egg activation; cyclin catabolic process; female meiosis I; female meiosis II. 10 alleles are reported. The phenotypes of these alleles are annotated with: pole cell; wing. It has one annotated transcript and one annotated polypeptide.

External Summaries

hide Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage
cort: cortex (T. Schupbach)
Maternal-effect lethal mutant; homozygous females lay eggs in which a narrow halo of clear cytoplasm appears in the cortex around the time when nuclei would be expected to migrate to the periphery, but no cellularization takes place.
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
26F6-26F6  
Limits computationally determined from genome sequence between P{EP}Sec61αEP2180 and P{lacW}Ate1k10809  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
26F-27A
 
(Chu, 2001.4.26)
27A-27A
Mapped using site-specific male recombination using P-elements.  
(Chu et al., 1999)
Experimentally Determined Recombination Data
Location
2-49
(Schupbach and Wieschaus, 1989)
Left of (cM)
(Chen et al., 1998)
(Chu et al., 2001)
(Chen and Chu, 1998.3.13)
Right of (cM)
(Chu et al., 2001)
Notes
Mapping uses male recombination stimulated by P\TΔ2-3.
(Chen et al., 1998)
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\cort for information on other features
detailed view FBtr0290322 FBtr0079321 FBtr0112506 FBtr0112507 FBtr0079320 FBtr0079319 FBtr0273249 FBtr0273250 FBtr0273247 FBtr0273248 FBpp0288761 FBpp0078950 FBpp0111420 FBpp0111419 FBpp0078949 FBpp0078948 FBpp0271757 FBti0070514 FBti0026453 FBti0069844 FBti0024442 FBti0054458 FBti0069543 FBti0054720 FBti0011059 FBti0006931
Comments on Gene Model
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
cort-RA
FBtr0079320
 NM_078770
  1700
  483
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
cort-PA  
FBpp0078949  
55.6  
483  
9.52  
  NP_523494
  AAF52421
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
•
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
•
WD40/YVTN repeat-like (IPR015943)
WD40 repeat (IPR001680)
WD40 repeat-like (IPR011046)
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
AE003614
AAF52421
 
AI511760
 
AW943651
 
AY033478
AAK54464
 
AY051966
AAK93390
 
BP556516
 
 
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    (BDGP Project Members, 2000-)
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    point mutation
    cort[QW55]
    2L:6,675,461..6,675,461
    evidence=experimental
    na_change=A6675461G
    pr_change=Y303C|cort-PA
    reported_na_change=A993G
    reported_pr_change=Y303C
    (Chu et al., 2001)
    point mutation
    cort[RH65]
    2L:6,674,959..6,674,959
    comment=TGG to TGA
    evidence=experimental
    na_change=G6674959A
    pr_change=W431@|cort-PA
    reported_na_change=G1378A
    reported_pr_change=W431@
    (Chu et al., 2001)
    protein binding site
    cort-protein_binding-1
    2L:6,676,606..6,676,637
    bound_moiety=grau-XP
    comment=grau protein is necessary for high-level activation of cort gene transcription.
    evidence=experimental
    (Harms et al., 2000)
    rescue fragment
    cort[+t4.2]
    2L:6,674,280..6,678,492
    comment=Position of rescue fragment on reference genome inferred by FlyBase curator.
    evidence=experimental
    linked_to=SpeI-EcoRI_rfrag
    (Chu et al., 2001)
    rescue fragment
    cort[+t2.8]
    2L:6,674,280..6,677,069
    comment=Position of rescue fragment on reference genome inferred by FlyBase curator.
    evidence=experimental
    linked_to=AvrII-EcoRI_rfrag
    (Chu et al., 2001)
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    •
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data     		Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
      Marker for
        Subcellular Localization
        CV Term
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0290322 FBtr0079321 FBtr0112506 FBtr0112507 FBtr0079320 FBtr0079319 FBtr0273249 FBtr0273250 FBtr0273247 FBtr0273248
        AI511760
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        •
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        •
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        •
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        lethal | embryonic stage | maternal effect | recessive
        Other Phenotypes
        Allele
        wild-type
        visible, with Scer\GAL4en-e16E
        meiotic cell cycle defective
        meiotic cell cycle defective | female (with cortQW55)
        meiotic cell cycle defective | female (with cortRH65)
        Sterility
        Allele
        female sterile
        female sterile | recessive
        Phenotype manifest in
        Allele
        pole cell | maternal effect
        wing | posterior compartment, with Scer\GAL4en-e16E
        hide Classical Alleles ( 3 )
        For All Classical Alleles Show

        Allele of cortClassMutagenStocksKnown lesion
        cortQW552 --
        cortRH650 --
        cortunspecified
          		0 --
          hide Alleles Carried on Transgenic Constructs ( 7 )
          For All Alleles Carried on Transgenic Constructs Show

          Allele of cortClassMutagenStocksKnown lesion
          cort+t16.20 Yes
          cort+t2.70 Yes
          cort+t2.80 Yes
          cort+t4.20 Yes
          cort+t7.70 Yes
          cortGD72742 Yes
          cortScer\UAS.P\T.T:Ivir\HA10 Yes
          hide Aneuploid Aberrations
          Useful duplication
           
          Disrupted in
          (Christensen and Cook, 2006.12.5)
          (Christensen and Cook, 2006.8.29)
          (Deal and Cook, 2001.12.20)
          (Ryder, 2004.4.26)
          hide Transgenic Constructs & Insertions
          Transgenic Constructs
          Type of construct
          Name
          Expression data
          UAS construct
          P{GD7274}
          NA
          P{UASp-cort.HA}
          NA
          characterization construct
          P{cort+t2.7}
          NA
          P{cort+t2.8}
          NA
          P{cort+t4.2}
          NA
          P{cort+t7.7}
          NA
          Insertions
          Type of insertions
          Name
          Expression data
          hide Related Comments
          Please look at the allele reports for the complete phenotype data
          Mutations in cort result in a maternal effect phenotype with defects during syncytial blastoderm formation.
          (Schupbach and Wieschaus, 1989)
          cort and grau genes are necessary for bcd protein expression. Mutations in cort impair bcd and other maternal patterning genes mRNA translation by disrupting cytoplasmic polyadenylation. bcd mRNA expression, localisation or processing are not affected. Mutations in cort do not block poly(A)-independent translational activation of nos mRNA. Phenotypic analysis demonstrates cort is required for initiation of development. Homozygous germ-line clones indicate cort is required in the germ-line. Temperature shift studies reveal cort is required at multiple stages of embryonic development.
          (Lieberfarb et al., 1996)
          grau and cort are involved in the developmental signalling of the completion of meiosis in females.
          (Page and Orr-Weaver, 1996)
          Eggs derived from mutant females arrest in metaphase of meiosis II.
          (Swan and Schupbach, 2007)
          hide Gene Ontology: Function, Process & Cellular Component ( 10 )
          hide Molecular Function
          CV term
          Evidence
          References
          molecular_function
          no biological data available
          (FlyBase Curators, 2002-)
          hide Biological Process
          CV term
          Evidence
          References
          cellularization
          inferred from mutant phenotype
          (Schupbach and Wieschaus, 1989)
          cyclin catabolic process
          inferred from mutant phenotype
          (Swan and Schupbach, 2007)
          egg activation
          inferred from mutant phenotype
          (Tadros et al., 2003)
          female meiosis
          inferred from mutant phenotype
          (Chu et al., 2001)
          female meiosis I
          inferred from genetic interaction with FLYBASE:fzy; FB:FBgn0001086
          (Swan and Schupbach, 2007)
          female meiosis II
          inferred from mutant phenotype
          (Swan and Schupbach, 2007)
          homologous chromosome segregation
          traceable author statement
          (Johnstone and Lasko, 2001)
          pole cell formation
          inferred from mutant phenotype
          (Schupbach and Wieschaus, 1989)
          hide Cellular Component
          CV term
          Evidence
          References
          cytoplasm
          inferred from direct assay
          (Chu et al., 2001)
          hide Sequence Ontology: Class of Gene
          protein_coding_gene
           
          nuclear_gene
           
          hide Interactions & Pathways
          hide Summary of Genetic Interactions
          Interacts with
          Please look at the allele data for full details of the genetic interactions
          cort allele
          Gene
          References
          cort+t2.7
          grau
          (Harms et al., 2000)
          cortQW55
          grau
          (Chen et al., 2000)
          cortRH65
          grau
          (Chen et al., 2000)
          unspecified
          Cks30A
          (Swan and Schupbach, 2007)
          hide External Data
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          hide Orthologs
          Genome-wide drosophilid orthologs
          Curated drosophilid orthologs
           
          Linkouts
          hide Functional Complementation between Species
          hide Inter-Species Misexpression Data
          Produces phenotype in
          Produces NO phenotype in
          hide Stocks & Reagents
          hide Stocks Listed in FlyBase ( 4 )
          VDRC
          v41472
          w1118; P{GD7274}v41472
          v41473
          w1118; P{GD7274}v41473/TM3
          Bloomington
          4974
          cortQW55 cn1 bw1/CyO, l(2)DTS5131
          Kyoto
          107978
          cortQW55 cn1 bw1/CyO, l(2)DTS5131
          hide Genomic Clones ( 2 )
          hide cDNA Clones ( 1 )
          Please Note
          This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
          cDNA Clones, Fully Sequenced
          BDGP DGC clones
          Other clones
          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          hide RNAi & Array Information
          Affy Oligo
          Linkouts
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          hide Antibody Information
          hide Other Information
          hide Discoverer
          hide Etymology
          hide Identification
          hide Position Effect Variegation Data
          hide Relationship to Other Genes
          Source for database identity of
          Source for database merge of
          Source for merge of: cort CG11330 Source for merge of cort CG11330 was sequence comparison (date:010530).
          (FlyBase, 1996-)
          Additional comments
          hide Comments About Role
          cort and fzy are required for anaphase progression in both female meiotic divisions, performing partially redundant roles in meiosis I and non-redundant roles in meiosis II.
          (Swan and Schupbach, 2007)
          hide Comments About Molecular Function
          hide Other Comments
          hide External Crossreferences & Linkouts
          Sequence Crossreferences
          RefSeq (Transcripts)
          •
          RefSeq (Proteins)
          •
          DDBJ / EMBL / GenBank
          •
          UniProtKB/Swiss-Prot
          •
          Other Crossreferences
          InterPro domains - A database of protein families, domains, and functional sites
          •
          WD40/YVTN repeat-like (IPR015943)
          WD40 repeat (IPR001680)
          WD40 repeat-like (IPR011046)
          Linkouts
          BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions
          •
          DEDB - Drosophila exon database: splicing graphs
          •
          DRSC - RNAi screening (Harvard): high-throughput cell culture data and design
          •
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          •
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          •
          FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans
          •
          GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
          •
          GenomeRNAi - RNAi phenotypes (Heidelberg): high-throughput cell culture data
          •
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          •
          PANTHER - Protein classification by function, families, and pathways
          •
          University of Chicago Dev. Expression
          •
          hide Synonyms & Secondary IDs ( 5 )
          Reported As
          Symbol Synonym
          CG11330
          (Giannakou and Dow, 2001, )
          cor
          (Foe et al., 1993)
          cort
          (Pesin and Orr-Weaver, 2007, Christensen and Cook, 2006.12.5, Christensen and Cook, 2006.8.29, Swan and Schupbach, 2007)
          Cort
          (Swan and Schüpbach, 2007)
          Name Synonym
          cortex
          (Harms et al., 2000, Pesin and Orr-Weaver, 2007, Swan and Schupbach, 2007)
          Secondary FlyBase IDs
          • FBgn0031847
          hide References ( 46 )
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          hide Recent research papers ( 1 )
          Swan and Schupbach, 2007, Development 134(5): 891--899
          The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila. [FBrf0194687]
          Show all research papers ...
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