HomeGene Dmel\Chc
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| Symbol | Dmel\Chc | Species | D. melanogaster | ||||||||||||||||||||
| Name | Clathrin heavy chain | Annotation symbol | CG9012 | ||||||||||||||||||||
| Feature type | protein_coding_gene | FlyBase ID | FBgn0000319 | ||||||||||||||||||||
| Created / Updated | 2003-12-01/2003-12-01 | ||||||||||||||||||||||
| Genomic Location | |||||||||||||||||||||||
| Chromosome (arm) | X | Recombination map | |||||||||||||||||||||
| Cytogenetic map | 13F5-13F7 | Sequence location | X:15,722,019..15,729,507 [-] | ||||||||||||||||||||
| Map ( GBrowse ) | 
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Summary Information
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Automatically generated summary
See sections below for more information | The gene Clathrin heavy chain is referred to in FlyBase by the symbol Chc (CG9012, FBgn0000319). It has the cytological map location 13F5-13F7. Its sequence location is X:15722019..15729507. Its molecular function is described as: protein binding; structural molecule activity. It is involved in the biological processes: sperm individualization; neurotransmitter secretion; synaptic vesicle coating; intracellular protein transport; vesicle-mediated transport. 14 alleles are reported. The phenotypes of these alleles are annotated with: spermatozoon; primary spermatocyte cyst; major mitochondrial derivative; minor mitochondrial derivative. It has 6 annotated transcripts and 6 annotated polypeptides. | ||||||||||||||||||||||
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Detailed Mapping Data
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| FlyBase Computed Cytological Location | |||||||||||||||||||||||
Cytogenetic map Evidence for location 13F5-13F7
Limits computationally determined from genome sequence between P{EP}BEST:RE35685EP1581&P{EP}sdEP1088 and P{EP}Gβ13FEP1071
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| Experimentally Determined Cytological Location | |||||||||||||||||||||||
Cytogenetic map Notes References 13F1-13F4 (determined by in situ hybridisation)
13F-13F Determined by comparing Celera genomic sequence with sequence from BDGP BAC and P1 clones.
13F1-13F4 (determined by in situ hybridisation)
13F2-13F2 (determined by in situ hybridisation)
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| Experimentally Determined Recombination Data | |||||||||||||||||||||||
| Location | |||||||||||||||||||||||
| Left of (cM) | |||||||||||||||||||||||
| Right of (cM) | |||||||||||||||||||||||
| Notes | |||||||||||||||||||||||
| Molecular Map Data | |||||||||||||||||||||||
Gene Order (in direction of increasing cytology)
References In direction of increasing cytology: sd? Chc? Myb? Gβ13F? Gapdh2? In direction of increasing cytology: sd+ Chc- Gene Order (overall orientation not stated) References | |||||||||||||||||||||||
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Gene Model & Products
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Please see the
GBrowse view of
Dmel\Chc
for information on other features
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| Comments on Gene Model | |||||||||||||||||||||||
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Transcript Data
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| Annotated Transcripts | |||||||||||||||||||||||
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) FBtr0112797
5667
1678 FBtr0112798
5560
1678 | |||||||||||||||||||||||
| Additional Transcript Data & Comments | |||||||||||||||||||||||
| Reported size (kB) | 5.4 (northern blot) | ||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| External Data | |||||||||||||||||||||||
| Crossreferences | |||||||||||||||||||||||
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Polypeptide Data
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| Annotated Polypeptides | |||||||||||||||||||||||
Name FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0111709
191.2
1678
5.46
FBpp0111710
191.2
1678
5.46
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| Additional Polypeptide Data & Comments | |||||||||||||||||||||||
| Reported size (kD) | 1678 (aa); 191 (kD predicted) | ||||||||||||||||||||||
| Comments | |||||||||||||||||||||||
| External Data | |||||||||||||||||||||||
| Linkouts | PANTHER
- Protein classification by function, families, and pathways
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| Crossreferences | InterPro
domains - A database of protein families, domains, and functional sites
• Regulator of chromosome condensation, RCC1 (IPR000408)
Clathrin, heavy chain/VPS, 7-fold repeat (IPR000547)
Clathrin, heavy chain, propeller, N-terminal (IPR001473)
Tetratricopeptide-like helical (IPR011990)
Clathrin, heavy chain, linker, core motif (IPR015348)
Armadillo-type fold (IPR016024)
Clathrin, heavy chain, linker and propeller (IPR016025)
Clathrin, heavy chain (IPR016341)
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Sequences Consistent with the Gene Model
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| DDBJ
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EMBL / GenBank | DNA sequence Protein sequence Name | ||||||||||||||||||||||
| UniProtKB/Swiss-Prot | |||||||||||||||||||||||
| UniProtKB/TrEMBL | |||||||||||||||||||||||
| Maps to | |||||||||||||||||||||||
| Does NOT map to | |||||||||||||||||||||||
| Identified with | |||||||||||||||||||||||
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Mapped Features & Mutations
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Please see
GBrowse
or insertion reports for information on insertions of transgenic
constructs and features not listed here
Type Symbol & Location Additional Notes References rescue fragment Chc[+t13] X:15,721,260..15,733,832 comment=Position of rescue fragment on reference sequence inferred by FlyBase curator. evidence=experimental linked_to=EcoRI-XbaI_rfrag | |||||||||||||||||||||||
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External Data
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| Linkouts | DEDB
- Drosophila exon database: splicing graphs
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| Crossreferences | |||||||||||||||||||||||
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Expression Data
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| FlyBase-Curated Data | |||||||||||||||||||||||
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Transcript and Protein data | Please see the FlyBase Gene Expression Report for details of gene expression from the literature. | ||||||||||||||||||||||
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Summary of Transcript Expression
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Stage Tissue/Position
Reference
adult stage | |||||||||||||||||||||||
| Marker for | |||||||||||||||||||||||
| Subcellular Localization | |||||||||||||||||||||||
| CV Term | |||||||||||||||||||||||
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Summary of Polypeptide Expression
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Stage Tissue/Position
Reference
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| Marker for | |||||||||||||||||||||||
| Subcellular Localization | |||||||||||||||||||||||
| CV Term | |||||||||||||||||||||||
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Microarray Data
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Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002) 
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External Data & Images
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| Linkouts | FLIGHT
- Cell culture data for RNAi and other high-throughput technologies
FlyAtlas
- Adult expression by tissue, using Affymetrix Dros2 array
GEO (NCBI)
- Gene expression data: microarray and other high-throughput technologies
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Alleles & Phenotypes
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Summary of Allele Phenotypes
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Lethality Allele Other Phenotypes Allele Sterility Allele Phenotype manifest in Allele spermatid & nucleus | |||||||||||||||||||||||
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Classical Alleles
( 9 ) | |||||||||||||||||||||||
| For All Classical Alleles Show | |||||||||||||||||||||||
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