Gene Dmel\chic

General Information
Symbol	Dmel\chic	Species	D. melanogaster
Name	chickadee	Annotation symbol	CG9553
Feature type	protein_coding_gene	FlyBase ID	FBgn0000308
Created / Updated	2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)	2L	Recombination map	2-
Cytogenetic map	26A5-26B2	Sequence location	2L:5,972,900..5,981,025 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene chickadee is referred to in FlyBase by the symbol chic (CG9553, FBgn0000308). It has the cytological map location 26A5-26B2. Its sequence location is 2L:5972900..5981025. Its molecular function is described as: actin binding; phosphatidylinositol-4,5-bisphosphate binding. It is involved in the biological processes described with 14 unique terms, many of which group under: anatomical structure development; organelle organization and biogenesis; actin filament-based process; cellular macromolecule metabolic process; gamete generation; cell division; central nervous system development; organ development; cell cycle; sexual reproduction; system development; ovarian nurse cell to oocyte transport; karyosome formation; anterior/posterior axis specification. 58 alleles are reported. The phenotypes of these alleles are annotated with 36 unique terms, many of which group under: organ system; nervous system; adult segment; anatomical structure; peripheral nervous system; adult mesothoracic segment; egg; spermatocyte; gamete; embryonic nervous system; adult brain. It has 4 annotated transcripts and 4 annotated polypeptides.
External Summaries

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	chic: chickadee (T. Schupbach) Female sterile; nurse cell contents are not transported into the egg, and homozygous females lay tiny eggs, which remain unfertilized.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 26A5-26B2 Limits computationally determined from genome sequence between P{EP}bchs^EP2299&P{EP}Gpdh^EP466 and P{lacW}chic^k13321
Experimentally Determined Cytological Location
Cytogenetic map Notes References 26A5-26A6 (determined by in situ hybridisation) (Spradling et al., 1999) 26A-26A (determined by in situ hybridisation) (Giansanti et al., 1998) 26A-26A (determined by in situ hybridisation) (Cooley et al., 1992)
Experimentally Determined Recombination Data
Location	2- (van Vactor et al., 1993)
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References Overall orientation not stated: ifc+ eIF-4a- chic+ (Basu and Li, 1998)
Gene Model & Products
Please see the GBrowse view of Dmel\chic for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) chic-RA FBtr0079233 NM_057668 1315 126 chic-RB FBtr0079235 NM_134304 1399 126 chic-RC FBtr0079234 NM_164667 1513 126 chic-RD FBtr0079236 NM_205913 1313 126
Additional Transcript Data & Comments
Reported size (kB)	1.2, 1.0 (northern blot) (Cooley et al., 1992)
Comments	The two classes of chi transcripts utilize different leader exons. The ovary specific transript contains exon 1. (Cooley et al., 1992) This transcription unit initiates at exon 2. (Cooley et al., 1992) Overexpression of the chi cDNA in fission yeast causes inhibition of cell division and complete disruption of cell shape and of the actin cytoskeleton. (Edwards et al., 1994)
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein chic-PA FBpp0078864 13.7 126 5.05 NP_477016 AAF52315 chic-PB FBpp0078866 13.7 126 5.05 NP_599131 AAF52316 chic-PC FBpp0078865 13.7 126 5.05 NP_723136 AAN10565 chic-PD FBpp0089196 13.7 126 5.05 NP_995635 AAS64643
Additional Polypeptide Data & Comments
Reported size (kD)	126 (aa) (Cooley et al., 1992)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0000308
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Profilin/allergen (IPR002097) Profilin, plant (IPR005455)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA264383 AA390941 AA441071 AA536456 AA539100 AA540038 AA940980 AA950192 AA950475 AC004268 AC004758 AC092239 AE003612 AAF52315 AE003612 AAF52316 AE003612 AAN10565 AE003612 AAS64643 AI062186 AI108892 AI294292 AI296300 AI296440 AI296502 AI296568 AI389418 AI403461 AI455888 AI533537 AQ025026 AQ025993 AQ026056 AQ026482 AQ073404 AQ254819 AW942382 AY069444 AAL39589 AY128443 AAM75036 BF490195 BF501155 BG637997 BG639219 BI163172 BI170322 BI172211 BI212413 BI214061 BI228971 BI230501 BI230788 BI235018 BI235052 BI236165 BI240335 BI241563 BI357071 BI357508 BI357537 BI358282 BI358468 BI361788 BI365307 BI366178 BI366674 BI366829 BI371151 BI371681 BI374261 BI482218 BI482660 BI484455 BI485584 BI486051 BI487105 BI563627 BI564300 BI565499 BI566389 BI566479 BI566516 BI568367 BI573370 BI573371 BI574426 BI575176 BI576407 BI577356 BI577689 BI578108 BI579790 BI581548 BI582908 BI583077 BI584214 BI585491 BI587103 BI588048 BI588201 BI588648 BI588852 BI589951 BI590166 BI590352 BI590550 BI612736 BI614858 BI615409 BI615603 BI618496 BI618853 BI619589 BI621534 BI627194 BI627564 BI628243 BI628382 BI629067 BI634607 BI635926 BI637744 BP545581 BP547927 BP549366 BP553061 BP555141 BP556350 BP556351 BP557167 BP557535 BP557536 BP558417 BQ103287 CA806680 CA807219 CK657625 CK658114 CK659924 CK662389 CL632151 CO152811 CO153259 CO153430 CO153544 CO153686 CO153798 CO154141 CO154427 CO154645 CO154897 CO154929 CO155089 CO155416 CO155447 CO155562 CO155584 CO156455 CO156741 CO156818 CO156868 CO178776 CO179909 CO180398 CO180492 CO181114 CO182031 CO183247 CO183414 CO189160 CO191406 CO194935 CO272021 CO274186 CO289140 CO295281 CO301631 CO307024 CO323791 CO329339 CO332113 CO335393 CO335432 CO335535 CO335875 CO335899 CO335925 CO336040 CO336451 CO336667 CO337887 CO337933 CO338273 CO338373 CW848232 CZ473038 CZ477197 CZ477632