Gene Dmel\cd

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General Information

Symbol

Dmel\cd

Species

D. melanogaster

Name

cardinal

Annotation symbol

Feature type

gene

FlyBase ID

FBgn0000272

Created / Updated

2006-08-22/2006-08-22

Genomic Location

Chromosome (arm)

Recombination map

3-75.7

Cytogenetic map

94A1-94E2

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene cardinal is referred to in FlyBase by the symbol cd (FBgn0000272). It has the cytological map location 94A1-94E2. It has not been localized to the genome sequence. Its molecular function is unknown. It is involved in the biological process ommochrome biosynthetic process. 17 alleles are reported. The phenotypes of these alleles are annotated with: eye; Malpighian tubule; pigment cell. It has no annotated transcripts.

Phenotypic Description from the Red Book (Lindsley & Zimm 1992)

Gene/Allele symbols may differ from current usage

cd: cardinal

Eye color yellowish vermilion, changing toward wild type with age. Drosopterin content of eyes about 85% normal (Gearhart and MacIntyre, 1970, Anal. Biochem. 37: 21-25). Phenoxazinone synthetase activity about 39% wild type; accumulates 3-hydroxykinurenine (Phillips, Forrest, and Kulkarni, 1973, Genetics 73: 45-56; Sullivan, Grillo, and Kitos, 1974, J. Exp. Zool. 188: 225-34). Ocelli white, showing no effect of age. Accumulates a blue-fluorescent compound termed cardinalic acid (xantherenic acid 8-O-β-O-glucoside) (Ferre, Mensua, and Jacobson, 1985, DIS 61: 71). Eye color autonomous in transplant of larval optic disk into wild type, ca, cn, st, or v larval host (Beadle and Ephrussi, 1936, Genetics 21: 230). Larval Malpighian tubes bright yellow; not distinguishable from wild type. RK2.

cdwo: cardinal-white ocelli

Ocelli colorless. Eye color wild type. Modifies we to a lighter and less yellow tone. cd/cdwo has normal eye color but white ocelli (Jones, 1971, DIS 47: 90). RK2.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94A1-94E2

Left limit from complementation mapping against T(Y;3)D100 (citation unavailable) Right limit from complementation mapping against Ts(YSt;3Rt)D100+Ts(YLt;3Lt)B27 (FBrf0022442)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-75.7

(Meyer, 1963, Nitasaka et al., 1995, Universita di Pavia, 1952)

Left of (cM)

Right of (cM)

(Plough and Ives, 1934)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

Mapped Features & Mutations

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0000272

Alleles & Phenotypes

Summary of Allele Phenotypes

Other Phenotypes

Allele

visible | recessive

eye color defective

Phenotype manifest in

Allele

eye

cd¹

Malpighian tubule

cd¹

pigment cell

Classical Alleles ( 17 )

For All Classical Alleles Show

Allele of cd	Class	Mutagen	Stocks	Known lesion
cd¹	amorph	spontaneous ethyl methanesulfonate	26	--
cd³		spontaneous	0	--
cd^45j		natural population	0	--
cd⁵⁹		spontaneous	0	--
cd⁶³		spontaneous	0	--
cd⁷⁹ⁱ		spontaneous natural population	0	--
cd^81d		spontaneous natural population	0	--
cd^H60		X ray	0	--
cd^KN187			0	--
cd^KN211			0	--
cd^KN308			0	--
cd^KN309			0	--
cd^KN50			0	--
cd^KP2	amorph	ethyl methanesulfonate	0	--
cd^W63		natural population	0	--
cd^unspecified			0	--
cd^wo	amorph	ethyl methanesulfonate	0	--

Alleles Carried on Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Allele of cd	Class	Mutagen	Stocks	Known lesion

Aneuploid Aberrations

Useful duplication

Dp(3;3)M95A⁺13

Disrupted in

Ts(YLt;3Lt)D100+Ts(YSt;3Rt)B27

(Jones, 1971)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

Insertions

Type of insertions

Name

Expression data

Related Comments

Please look at the allele reports for the complete phenotype data

Lesions in cd reduces pigmentation in the eye and eliminates pigmentation in the ocelli, tubule and fat body pigmentation remain unaffected.

(Tearle, 1991)

Gene Ontology: Function, Process & Cellular Component ( 1 )

Molecular Function

CV term

Evidence

References

Biological Process

CV term

Evidence

References

ommochrome biosynthetic process

inferred from mutant phenotype

(Tearle, 1991)

Cellular Component

CV term

Evidence

References

Sequence Ontology: Class of Gene

gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

cd allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

69554

Orthologs

Genome-wide drosophilid orthologs

Curated drosophilid orthologs

Dana\cd

(Sturtevant and Novitski, 1941)

Dazt\cd

(Sturtevant and Novitski, 1941)

Dfun\st

(Stubbe and Vogt, 1940)

Dhyd\st

(Hackstein et al., 1992)

Dmas\st

(Price, 1954)

Dpse\cn

(Sturtevant and Tan, 1937)

Dsim\cd

Dsub\cd

Linkouts

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 24 )

Bloomington

3052

cd¹

1892

Df(3R)G1, cd¹/TM3, Sb¹

586

Sb¹ H¹/In(3R)C, sprd¹ cd¹

1926

sr¹ r-l^K2 cd¹/TM3, Sb¹ Ser¹

4156

l(3)93Bd¹ e^LE1 cd¹/TM3, Sb¹ Ser¹

Kyoto

106560

Df(3R)G1, cd¹/TM3, Sb¹

101666

In(3R)C, cd¹ / Sb¹ H¹

105995

Sb¹ H¹/In(3R)C, sprd¹ cd¹

107631

Dl¹ H¹ e^s cd¹/In(3R)P, spr¹

107600

l(3)93Bd¹ e^LE1 cd¹/TM3, Sb¹ Ser¹

107601

l(3)93Bg¹ e^LE1 cd¹/TM3, Sb¹ Ser¹

107602

Rab11^93Bi e^LE1 cd¹/TM3, Sb¹ Ser¹

More stocks available...

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Affy Oligo

Linkouts

Antibody Information

Other Information

Discoverer

Johnson, 24th Nov. 1919.

Etymology

Identification

Position Effect Variegation Data

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Comments About Role

Comments About Molecular Function

Other Comments

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

69554

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0000272

FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans

•

FBgn0000272

Synonyms & Secondary IDs ( 2 )

Reported As

Symbol Synonym

Name Synonym

cardinal

(Savvateeva-Popova et al., 2007)

Secondary FlyBase IDs

References ( 33 )

Generate a list of

All references relating to this gene ( 33 )

List References by type

Research paper ( 29 )
Abstract ( 2 )
Book ( 2 )

Recent research papers (0)

All research papers listed in FlyBase were published before 2006

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