Gene Dmel\Argk

General Information
Symbol	Dmel\Argk	Species	D. melanogaster
Name	Arginine kinase	Annotation symbol	CG32031
Feature type	protein_coding_gene	FlyBase ID	FBgn0000116
Created / Updated	2003-12-01/2007-03-20
Genomic Location
Chromosome (arm)	3L	Recombination map	3-25.2
Cytogenetic map	66F3-66F4	Sequence location	3L:9,041,962..9,059,127 [-]
Map ( GBrowse )
Summary Information
Automatically generated summary See sections below for more information	The gene Arginine kinase is referred to in FlyBase by the symbol Argk (CG32031, FBgn0000116). It has the cytological map location 66F3-66F4. Its sequence location is 3L:9041962..9059127. Its molecular function is described as arginine kinase activity. It is involved in the biological process phosphorylation. 15 alleles are reported. No phenotypic data is available. It has 6 annotated transcripts and 6 annotated polypeptides.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Argk: Arginine kinase Structural gene for arginine kinase [ARGK (EC 2.7.3.3)] based on gene dosage studies. Cellular and mitochondrial forms behave as if both are products of the gene. (Munneke and Collier, 1985, Genetics 110: s85). In 108-hour third-instar larvae, activity is high in body-wall and digestive-tract musculature; lower in brain, imaginal discs, and salivary glands; present in head, thorax, and abdomen of adults, being highest in indirect flight muscle of thorax. Activity levels increase during development reaching a peak at the pupal stage; then an abrupt decrease during the pupal stage is followed by a second increase beginning around the time of eclosion and climbing to high adult levels (James and Collier).
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66F3-66F4 Limits computationally determined from genome sequence between P{PZ}l(3)01629⁰¹⁶²⁹&P{PZ}mRpL12¹⁰⁵³⁴ and P{EP}Hsp26^EP3336&P{EP}Hsp26^EP3315
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66F-66F (Hecht, 1995.5.11) 66F-66F (determined by in situ hybridisation) (Hecht et al., 1994) 66B-66B Segmental aneuploids (unspecified) identify 66B as the dosage sensitive region for Argk. (Munneke and Collier, 1985) 66B-66F Segmental aneuploids (unspecified) produced flies duplicated for region 66B-66F that exhibit elevated Argk activity. (Fu and Collier, 1981)
Experimentally Determined Recombination Data
Location	3-25.2 (Munneke and Collier, 1985) 3- (Choudhary et al., 1992) 1- (FlyBase, 1992-)
Left of (cM)
Right of (cM)	elav (FlyBase, 1992-)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Please see the GBrowse view of Dmel\Argk for information on other features
Comments on Gene Model

Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Argk-RA FBtr0076543 NM_168311 2433 562 Argk-RB FBtr0076544 NM_168312 2196 432 Argk-RC FBtr0076546 NM_168313 2117 396 Argk-RD FBtr0076545 NM_079264 1535 356 Argk-RE FBtr0112791 NM_001104085 1872 375 Argk-RF FBtr0112792 NM_001104086 1621 356
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein Argk-PA FBpp0076270 61.3 562 7.58 NP_729446 AAF50325 Argk-PB FBpp0076271 47.9 432 5.90 NP_729447 AAN11982 Argk-PC FBpp0076273 43.8 396 6.08 NP_729448 AAF50326 Argk-PD FBpp0076272 39.9 356 6.43 NP_523988 AAN11983 Argk-PE FBpp0111703 42.2 375 6.26 NP_001097555 ABW08501 Argk-PF FBpp0111704 39.9 356 6.43 NP_001097556 ABW08502
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts	PANTHER - Protein classification by function, families, and pathways • FBgn0000116
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Glutamine synthetase/guanido kinase, catalytic region (IPR014746) ATP:guanido phosphotransferase (IPR000749)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA540871 AA694669 AA698565 AA801500 AA803415 AE003553 AAF50325 AE003553 AAF50326 AE003553 AAN11982 AE003553 AAN11983 AI063798 AI106841 AI106987 AI107314 AI107357 AI107630 AI108324 AI113742 AI134260 AI134638 AI134840 AI135401 AI293560 AI294603 AI295507 AI296235 AI387840 AI388496 AI388865 AI389832 AI402280 AI403288 AI403774 AI404396 AI405638 AI405903 AI456953 AI513350 AI514039 AI519149 AI532471 AI534909 AW940421 AY069099 AAL39244 BF499094 BF499123 BF504447 BF505117 BF506181 BG632129 BG633180 BG633308 BG633525 BG636611 BI163075 BI163909 BI165865 BI166672 BI167418 BI168885 BI169160 BI171923 BI172768 BI173314 BI214975 BI216005 BI216020 BI231924 BI234088 BI238942 BI352756 BI354889 BI355847 BI356661 BI372638 BI373319 BI375048 BI481905 BI482031 BI482814 BI483239 BI483369 BI485986 BI563387 BI563617 BI563777 BI564008 BI564054 BI564437 BI564798 BI564890 BI564949 BI565090 BI565479 BI565793 BI566260 BI566799 BI567002 BI567054 BI567069 BI567254 BI567465 BI567568 BI567573 BI567622 BI567901 BI568086 BI568121 BI568263 BI568299 BI568402 BI568416 BI568688 BI570117 BI570220 BI570771 BI571641 BI572208 BI572315 BI572589 BI572801 BI573121 BI574197 BI574371 BI574447 BI574590 BI574639 BI574670 BI574695 BI574702 BI574904 BI575138 BI575216 BI575232 BI575692 BI575813 BI576212 BI576238 BI576248 BI576654 BI576866 BI576914 BI577432 BI577784 BI581170 BI581454 BI581506 BI581597 BI582428 BI582607 BI582812 BI583016 BI583330 BI583680 BI583830 BI583948 BI584289 BI584445 BI584454 BI584583 BI584666 BI584789 BI584790 BI584812 BI584821 BI584865 BI584988 BI585563 BI585581 BI585657 BI586010 BI586194 BI586249 BI586467 BI586517 BI586903 BI587440 BI587953 BI588233 BI588378 BI588645 BI588677 BI588754 BI588758 BI588775 BI588842 BI588854 BI589049 BI589114 BI589240 BI589365 BI589782 BI589872 BI589990 BI590243 BI590357 BI590593 BI590758 BI590774 BI590775 BI590974 BI591289 BI591463 BI591804 BI592036