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Gene Dmel\Aph-1

General Information
Symbol	Dmel\Aph-1	Species	D. melanogaster
Name	Alkaline phosphatase 1	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0000106
Created / Updated	2006-08-22/2006-08-22
Genomic Location
Chromosome (arm)		Recombination map	3-47.3
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Alkaline phosphatase 1 is referred to in FlyBase by the symbol Aph-1 (FBgn0000106). It has not been localized to the genome sequence. Its molecular function is described as alkaline phosphatase activity. The biological processes in which it is involved are not known. 6 alleles are reported. No phenotypic data is available. It has no annotated transcripts.
Phenotypic Description from the Red Book (Lindsley & Zimm 1992)
Gene/Allele symbols may differ from current usage	Aph-1: Alkaline phosphatase-1 Locus responsible for one of several different alkaline phosphatase species [APH1 (EC 3.1.3.1)] formed during the life cycle. Specifies the enzyme that becomes active in the larval cuticle and muscle during the third instar. Electrophoretic mobility of a pupal form of the enzyme, which differs from that found in the larva, also appears to be controlled by this locus (Wallis and Fox). Dimeric nature of enzyme inferred from the presence of enzymes of hybrid mobility in larvae heterozygous for electrophoretic variants. Biochemical characterization of larval enzyme by Harper and Armstrong (1972, Biochem. Genet. 6: 75-82; 1973, Biochem. Genet. 10: 29-38; 1974, Biochem. Genet. 11: 177-80).
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-47.3 (Wallis and Fox, 1968) 3- (Beckman and Johnson, 1964, Choudhary et al., 1992) 3-46.3 +/- 0.5 (MacIntyre, 1966)
Left of (cM)	p (Wallis and Fox, 1968)
Right of (cM)	W (Wallis and Fox, 1968)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology) References Gene Order (overall orientation not stated) References
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kD) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Maps to
Does NOT map to
Identified with
Mapped Features & Mutations
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
FlyBase-Curated Data
Transcript and Protein data	Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
Summary of Transcript Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
Summary of Polypeptide Expression
Stage Tissue/Position Reference
Marker for
Subcellular Localization
CV Term
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000106
Alleles & Phenotypes
Summary of Allele Phenotypes
Other Phenotypes Allele electrophoretic variant Aph-10 Aph-110 Aph-12 Aph-1A Aph-1F Aph-1S electrophoretic variant | slow Aph-12 Aph-1S electrophoretic variant | fast Aph-110 Aph-1A Aph-1F Phenotype manifest in Allele
Classical Alleles ( 6 )
For All Classical Alleles Show
Allele of Aph-1 Class Mutagen Stocks Known lesion Aph-10 loss of function natural population 0 -- Aph-110 natural population 0 -- Aph-12 natural population 0 -- Aph-1A natural population 0 -- Aph-1F natural population 0 -- Aph-1S natural population 0 --
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Aph-1 Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Related Comments
	Please look at the allele reports for the complete phenotype data Electrophoretic variation in the larval Aph-1 gene has been found. Inheritance of these enzyme variations is controlled by a pair of codominant alleles. (Beckman and Johnson, 1964) An intimate relationship exists between larval and pupal Aph-1 with regards to developmental, electrophoretic and genetic properties. (Wallis and Fox, 1968) Two forms of the enzyme are very similar in their properties (except pH optima). (Harper and Armstrong, 1972) Four forms of the enzyme are very similar in their properties (except pH optima and protein thermal stability). (Harper and Armstrong, 1973)
Gene Ontology: Function, Process & Cellular Component ( 1 )
Molecular Function
CV term Evidence References
alkaline phosphatase activity inferred from direct assay (Harper and Armstrong, 1972)
Biological Process
CV term Evidence References
Cellular Component
CV term Evidence References
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Aph-1 allele Gene References
External Data
Linkouts
Orthologs
Genome-wide drosophilid orthologs
Curated drosophilid orthologs	Dbii\Aph-1   Dbip\Aph   Dele\Aph-1   Deug\Aph-1   Dmat\Aph   Dprs\Aph-1   Dwil\Aph-1 (Lakovaara and Saura, 1972) Dyak\Aph-1
Linkouts
Functional Complementation between Species
Inter-Species Misexpression Data
Produces phenotype in
Produces NO phenotype in
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Affy Oligo
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Position Effect Variegation Data
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Comments About Role
	Locus responsible for one of several different alkaline phosphatase species (APH1). APH1 becomes active in the larval cuticle and muscle during the third instar. Electrophoretic mobility of a pupal form of the enzyme, which differs from that found in the larva, also appears to be controlled by this locus (FBrf0019197).
Comments About Molecular Function
Other Comments
	That the larval and pupal enzymes are differently modified products of the same locus is indicated by genetic inseparability and by concordance in the orders of mobilities of electrophoretic alleles (FBrf0019197).
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0000106 FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0000106
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	AP (Sukhanova et al., 1998) APH (Bondinas et al., 2002, Bondinas et al., 2001, Choudhary et al., 1992, Johnson, 1966) Aph (Zapata et al., 2002, MacIntyre, 1966, Ehiobu et al., 1990, Harper and Armstrong, 1974, Harper and Armstrong, 1973, Harper and Armstrong, 1972, Beckman and Johnson, 1964, ) Aph-1   l-Aph (Wallis and Fox, 1968) p-Aph (Wallis and Fox, 1968) unnamed (Beckman and Johnson, 1964)
Name Synonym	Alkaline phosphatase (Sukhanova et al., 1998, Beckman and Johnson, 1964) Alkaline phosphatase 1   larval Alkaline phosphatase (Wallis and Fox, 1968) pupal Alkaline phosphatase (Wallis and Fox, 1968)
Secondary FlyBase IDs
References ( 18 )
Research paper	Davis et al., 2003, Dev. Biol. 259(2): 272--287 Drosophila retinal homeobox (drx) is not required for establishment of the visual system, but is required for brain and clypeus development. [FBrf0160472] Bondinas et al., 2002, Chromosoma 111(4): 256--266 The actin loci in the genus Drosophila: establishment of chromosomal homologies among five nearctic species of the Drosophila obscura group by in situ hybridization. [FBrf0151822] Zapata et al., 2002, Genetics 161(4): 1539--1550 Distribution of nonrandom associations between pairs of protein loci along the third chromosome of Drosophila melanogaster. [FBrf0152025] Bondinas et al., 2001, Chromosoma 110(7): 441--450 The actin loci in the genus Drosophila: establishment of chromosomal homologies among five palearctic species of the Drosophila obscura group by in situ hybridization. [FBrf0144770] Sukhanova et al., 1998, Dokl. Akad. Nauk 359(6): 836--837 [Alkaline phosphatase in the Drosophila melanogaster strain characterized by differences in sexual behavior of males in normal and stressful conditions.] [FBrf0103377] Sukhanova et al., 1998, Genetika, Moscow 34(9): 1239--1242 [Alkaline phosphatase in Drosophila melanogaster strains differing in male mating activity and their F1 hybrids.] [FBrf0107320] Choudhary et al., 1992, Genetics 130(4): 843--853 A comprehensive study of genic variation in natural populations of Drosophila melanogaster. [FBrf0056264] Ehiobu et al., 1990, Theoret. Appl. Genet. 80(3): 321--325 Prediction of heterosis in crosses between inbred lines of Drosophila melanogaster. [FBrf0053016] Harper and Armstrong, 1974, Biochem. Genet. 11(2): 177--180 Alkaline phosphatase of Drosophila melanogaster. [FBrf0025885] Harper and Armstrong, 1973, Biochem. Genet. 10: 29--38 Alkaline phosphatase of Drosophila melanogaster. [FBrf0024598] Harper and Armstrong, 1972, Biochem. Genet. 6: 75--82 Alkaline phosphatase of Drosophila melanogaster. [FBrf0023415] Lakovaara and Saura, 1972, D. I. S. 48: 93 Location of 13 enzyme loci in D. willistoni. [FBrf0023739] Wallis and Fox, 1968, Biochem. Genet. 2: 141--158 Genetic and developmental relationships between two alkaline phosphatases in Drosophila melanogaster. [FBrf0019197] Johnson, 1966, Science 152: 361--362 Drosophila melanogaster: inheritance of a deficiency of alkaline phosphatase in larvae. [FBrf0018136] MacIntyre, 1966, D. I. S. 41: 62 Locus of the structural gene for 3rd larval instar alkaline phosphatase (Aph). [FBrf0091310] Beckman and Johnson, 1964, Nature 201: 321 Genetic variations of phosphatases in larvae of Drosophila melanogaster. [FBrf0016485] Beckman and Johnson, 1964, Genetics 49: 829--835 Variations in larval alkaline phosphatase controlled by Aph alleles in Drosophila melanogaster. [FBrf0016293]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]