Allele Dmel\Fmr1^{I307N.Z.Scer\UAS}

General Information
Symbol	Dmel\Fmr1^{I307N.Z.Scer\UAS}	Species	D. melanogaster
Name		FlyBase ID	FBal0131028
Feature type	allele	Created / Updated	2006-08-20/2006-08-20
Associated gene	Dmel\Fmr1

Allele class
Mutagen	in vitro construct \| amino acid replacement
Nature of the Allele
Allele class
Mutagen	in vitro construct \| amino acid replacement (Zhang et al., 2001)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Fmr1^Scer\UAS.cZa (Zhang et al., 2001)
Nature of the lesion	Statement Reference Construct: Amino acid replacement: I307N. (Zhang et al., 2001)
Assay mode	In transgenic Drosophila (intraspecific) (Zhang et al., 2001)
Carried in construct	P{UAS-Fmr1.I307N.Z} (Zhang et al., 2001)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| pupal stage, with Scer\GAL4^G7 (Zhang et al., 2001) lethal \| adult stage, with Scer\GAL4^elav-C155 (Zhang et al., 2001) lethal, with Fmr1^Scer\UAS.cZa, Scer\GAL4^elav-C155 (Zhang et al., 2001) visible, with Scer\GAL4^elav-C155 (Zhang et al., 2001) uncoordinated, with Scer\GAL4^elav-C155 (Zhang et al., 2001) flightless, with Scer\GAL4^elav-C155 (Zhang et al., 2001) flightless, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) neurophysiology defective, with Scer\GAL4^hs.2sev (Zhang et al., 2001)
Phenotype Manifest In
	wing, with Scer\GAL4^elav-C155 (Zhang et al., 2001) wing, with Scer\GAL4^Mhc.PW (Zhang et al., 2001) rhabdomere, with Scer\GAL4^hs.2sev (Zhang et al., 2001) photoreceptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001) ommatidium, with Scer\GAL4^hs.2sev (Zhang et al., 2001) photoreceptor cell & synapse & lamina receptor cell, with Scer\GAL4^hs.2sev (Zhang et al., 2001)
Detailed Description
	Statement Reference The phenotypes produced by Fmr1^{I307N.Z.Scer\UAS} are similar but consistently weaker than those produced by Fmr1^Scer\UAS.cZa. When expression is driven by Scer\GAL4^elav-C155 flies show abnormally outspread wings and cannot fly. Flies are uncoordinated and show adult lethality - dying 5-10 days post-eclosion. When expression is driven by Scer\GAL4^Mhc.PW flies' wings are droopy or held up and they cannot fly. When expression is driven by Scer\GAL4^G7 flies show pupal lethality. When expression is driven by Scer\GAL4^hs.2sev the retina is disordered with misshapen rhabdomeres, abnormal rhabdomere numbers and fused ommatidia. Phototransduction is normal, however synaptic transmission is reduced (as indicated by a reduction in off-transient mean amplitude as assayed by ERG). (Zhang et al., 2001)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 1 )
Reported As
Symbol Synonym	Fmr1^{I307N.Z.Scer\UAS}
Name Synonym
Secondary FlyBase IDs

References ( 1 )
Research paper	Zhang et al., 2001, Cell 107(5): 591--603 Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. [FBrf0141416]

Allele Dmel\Fmr1I307N.Z.Scer\UAS

Allele Dmel\Fmr1^{I307N.Z.Scer\UAS}