A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\futschP158

General Information
SymbolDmel\futschP158SpeciesD. melanogaster
NameFlyBase IDFBal0118228
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\futsch
Allele classamorph
Mutagen
hide Nature of the Allele
Allele class
amorph
(Hummel et al., 2000)
Mutagen
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal
      (Hummel et al., 2000)
      hide Phenotype Manifest In
      sensory nerve & dendrite
      (Hummel et al., 2000)
      axon
      (Hummel et al., 2000)
      longitudinal connective
      (Hummel et al., 2000)
      abdominal posterior fascicle neuron
      (Hummel et al., 2000)
      motor neuron
      (Hummel et al., 2000)
      hide Detailed Description
      Statement
      Reference
      In mutant larvae, 97% of the peripheral nervous system (PNS) neurons fail to develop their normal dendritic morphology. Axonal growth is also impaired, few axons grow normally into the central nervous system (CNS). Axonal pathfinding is not affected - axons appear to simply stop after growing some distance. In mutants, longitudinal connectives are reduced, also disruptions in motoneural connections are observed. In particular SNb nerves fail to reach muscle fibres 12 and 13. Motor neurons stall and fail to set up the correct innervation pattern in 89% of the segments.
      (Hummel et al., 2000)
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      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 0 )
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      futschP158
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 1 )
        Research paper
        Hummel et al., 2000, Neuron 26(2): 357--370
        Drosophila Futsch/22C10 is a MAP1B-like protein required for dendritic and axonal development. [FBrf0128497]