A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\maelr20

General Information
SymbolDmel\maelr20SpeciesD. melanogaster
NameFlyBase IDFBal0082458
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\mael
Allele class
MutagenΔ2-3
hide Nature of the Allele
Allele class
Mutagen
Δ2-3
(Clegg et al., 1997)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      mael11A4
      (Clegg et al., 1997)
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      hide Phenotype Manifest In
      oocyte & centriole (with Df(3L)79E-F)
      (Clegg et al., 2001)
      oocyte & microtubule organizing center (with Df(3L)79E-F)
      (Clegg et al., 2001)
      chorion | germ-line clone
      (Clegg et al., 1997)
      oocyte | germ-line clone
      (Clegg et al., 1997)
      egg chamber
      (Clegg et al., 1997)
      follicle cell
      (Clegg et al., 1997)
      dorsal appendage
      (Clegg et al., 1997)
      microtubule & oocyte
      (Clegg et al., 1997)
      hide Detailed Description
      Statement
      Reference
      Mutant egg chambers have two anterior organising centres. Posterior follicle cells adopt anterior fates. Follicle cell fates along the D/V axis are also altered. Dorsal appendages are fused or lost and the follicle cell imprints on the dorsal side of the egg are more rounded than in wild-type. Mutant eggs are slightly smaller than wild-type. Microtubule cytoskeleton in maelr15/maelr20 oocytes is defective due to premature streaming of the microtubules. Germline mosaics reveal mael acts in the germline, mosaics exhibit egg shell and oocyte polarity defects.
      (Clegg et al., 1997)
      The focus of anti-tubulin staining is located anteriorly or laterally in stage 2-6 maelr20/Df(3L)79E-F oocytes (but not at the posterior as in wild type) consistent with the hypothesis that the microtubule organising centre is misplaced. "Loose" centriole clusters are seen either at the anterior of the oocyte or near the lateral surface in stage 2 maelr20/Df(3L)79E-F oocytes, in contrast to wild type where the centriole cluster is at the extreme posterior.
      (Clegg et al., 2001)
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      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 1 )
      Bloomington
      8516
      w*; maelr20/TM3, Sb1
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      maelr20
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 3 )
        Research paper
        Cook et al., 2004, Cell 116(6): 817--829
        The Drosophila SDE3 homolog armitage is required for oskar mRNA silencing and embryonic axis specification. [FBrf0174441]
        Clegg et al., 2001, Dev. Genes Evol. 211(1): 44--48
        maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes. [FBrf0134556]
        Clegg et al., 1997, Development 124(22): 4661--4671
        maelstrom is required for an early step in the establishment of Drosophila oocyte polarity: posterior localization of grk mRNA. [FBrf0099733]