A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\srG11

General Information
SymbolDmel\srG11SpeciesD. melanogaster
NameFlyBase IDFBal0050558
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\sr
Allele class
MutagenΔ2-3
hide Nature of the Allele
Allele class
Mutagen
Δ2-3
(Frommer et al., 1996)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      sr03999
      (Frommer et al., 1996)
      Nature of the lesion
      Statement
      Reference
      2074bp deletion of genomic DNA due to imprecise deletion of the P{PZ} insertion of sr03999.
      (Frommer et al., 1996)
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      lethal | recessive
      (Ghazi et al., 2000)
      lethal | embryonic stage | recessive
      (Frommer et al., 1996)
      hide Phenotype Manifest In
      embryonic/larval dorsal branch
      (Dorfman et al., 2002)
      embryonic/larval dorsal trunk
      (Dorfman et al., 2002)
      embryonic/larval ganglionic branch
      (Dorfman et al., 2002)
      hide Detailed Description
      Statement
      Reference
      Homozygous embryos have a normal somatic muscle pattern and generally hatch, although they do not develop into adult flies. Homozygous srG11 embryos that are expressing srScer\UAS.cBa under the control of Scer\GAL4en-e16E show a severe disruption of the somatic muscle pattern, especially that of the lateral transverse muscles.
      (Becker et al., 1997)
      A reduced number of cells are found in the dorsal and ganglionic branches, and the dorsal trunk branches fail to fuse though, tracheal migration is generally normal in homozygous mutants and terminal cell differentiation is not affected.
      (Dorfman et al., 2002)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hideEnhancer of
      Statement
      Reference
      sr[+]/srG11 is an enhancer of indirect flight muscle phenotype of ap4
      (Ghazi et al., 2000)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 0 )
      hide Notes on Origin
      Discoverer
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      srG11
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 4 )
        Research paper
        Dorfman et al., 2002, Dev. Biol. 252(1): 119--126
        Stripe provides cues synergizing with branchless to direct tracheal cell migration. [FBrf0155479]
        Ghazi et al., 2000, Development 127(24): 5309--5318
        Apterous mediates development of direct flight muscles autonomously and indirect flight muscles through epidermal cues. [FBrf0131298]
        Becker et al., 1997, Development 124(13): 2615--2622
        Reciprocal signaling between Drosophila epidermal muscle attachment cells and their corresponding muscles. [FBrf0094132]
        Frommer et al., 1996, EMBO J. 15(7): 1642--1649
        Epidermal egr-like zinc finger protein of Drosophila participates in myotube guidance. [FBrf0087142]