Allele Dmel\l(1)sc^Scer\UAS.cHa

General Information
Symbol	Dmel\l(1)sc^Scer\UAS.cHa	Species	D. melanogaster
Name	Saccharomyces cerevisiae UAS construct a of Hinz	FlyBase ID	FBal0045936
Feature type	allele	Created / Updated	2006-08-20/2006-08-20
Associated gene	Dmel\l(1)sc

Allele class
Mutagen	in vitro construct \| regulatory fusion
Nature of the Allele
Allele class
Mutagen	in vitro construct \| regulatory fusion (Hinz et al., 1994, Hinz et al., 1993, Klein and Campos-Ortega, 1997)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: Expression of l(1)sc cDNA is governed by Scer\UAS regulatory sequences. (Hinz et al., 1994)
Assay mode	In transgenic Drosophila (intraspecific) (Hinz et al., 1993, Klein and Campos-Ortega, 1997, Hinz et al., 1994)
Carried in construct	P{UAS-l(1)sc.LSC} (Giebel, 1999, Rottgen et al., 1998, Hinz et al., 1993, Hinz et al., 1994, Cooper et al., 2000, Stollewerk, 2000, Nagel et al., 2000, Jennings et al., 1999, Klein and Campos-Ortega, 1997, Brand and Dormand, 1995, Hoch and Jackle, 1998, Giebel et al., 1997, Giebel and Campos-Ortega, 1997, Apidianakis et al., 1999)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| embryonic stage, with Scer\GAL4^da.G32 (Giebel et al., 1997) visible, with Scer\GAL4^455.2 (Rottgen et al., 1998) visible, with Scer\GAL4^sca-537.4 (Nagel et al., 2000) visible, with Scer\GAL4^ptc-559.1 (Apidianakis et al., 1999)
Phenotype Manifest In
	macrochaeta & scutellum, with Scer\GAL4^455.2 (Hinz et al., 1994) scutellar bristle, with Scer\GAL4^455.2 (Rottgen et al., 1998) scutellar bristle \| ectopic, with Scer\GAL4^455.2 (Rottgen et al., 1998, Giebel and Campos-Ortega, 1997) macrochaeta \| ectopic, with Scer\GAL4^sca-537.4 (Nagel et al., 2000) macrochaeta & abdominal sternite 1, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & abdominal sternite 2, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & abdominal sternite 3, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & abdominal sternite 4, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & abdominal sternite 5, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & abdominal sternite 6, with Scer\GAL4^sca-537.4 (Hinz et al., 1994) macrochaeta & pronotum, with Scer\GAL4^h-540.3 (Hinz et al., 1994) macrochaeta & scutum, with Scer\GAL4^h-540.3 (Hinz et al., 1994) macrochaeta & metathoracic laterotergite, with Scer\GAL4^h-540.3 (Hinz et al., 1994) macrochaeta & mesothoracic laterotergite, with Scer\GAL4^h-540.3 (Hinz et al., 1994) microchaeta & pronotum, with Scer\GAL4^h-540.3 (Hinz et al., 1994) microchaeta & scutum, with Scer\GAL4^h-540.3 (Hinz et al., 1994) microchaeta & metathoracic laterotergite, with Scer\GAL4^h-540.3 (Hinz et al., 1994) microchaeta & mesothoracic laterotergite, with Scer\GAL4^h-540.3 (Hinz et al., 1994) microchaeta, with Scer\GAL4^527.3 (Hinz et al., 1994) wing vein, with Scer\GAL4^527.3 (Hinz et al., 1994) macrochaeta & wing, with Scer\GAL4^564.2 (Hinz et al., 1994) scutellar bristle \| ectopic, with Scer\GAL4^ptc-559.1 (Apidianakis et al., 1999) scutellum & microchaeta, with Scer\GAL4^ptc-559.1 (Apidianakis et al., 1999) microchaeta \| ectopic, with Scer\GAL4^ptc-559.1 (Apidianakis et al., 1999) sensory mother cell & dorsal mesothoracic disc, with Scer\GAL4^ap-md544 (Apidianakis et al., 1999) chordotonal organ with two scolopidia, with Scer\GAL4^da.G32 (Giebel et al., 1997) monoscolopidial chordotonal organ, with Scer\GAL4^da.G32 (Giebel et al., 1997) lateral ventral neurectoderm, with Scer\GAL4^da.G32 (Stollewerk, 2000) medial ventral neurectoderm, with Scer\GAL4^da.G32 (Stollewerk, 2000) intermediate ventral neurectoderm, with Scer\GAL4^da.G32 (Stollewerk, 2000) stage 1 neuroblast, with Scer\GAL4^da.G32 (Stollewerk, 2000)
Detailed Description
	Statement Reference Ectopic external sense organs develop, macrochaetae, microchaetae and campaniform sensilla, on virtually every part of the body. Extra veins with microchaetae also develop on the wing blade. (Hinz et al., 1994) Neural hypoplasia of the CNS and PNS in Df(1)260-1 hemizygous embryos is strongly reduced by Scer\GAL4^da.G32-mediated expression of l(1)sc^Scer\UAS.cHa. Scer\GAL4^da.G32-mediated expression is not sufficient to promote the development of ectopic nerve cells in wild type embryos, but does cause defects in internal sensory organs. (Giebel et al., 1997) In strain ZB1.4 the activator insertion Scer\GAL4^455.2 is combined with l(1)sc^Scer\UAS.cHa causing the development of 10 ectopic scutellar macrochaetes. (Giebel and Campos-Ortega, 1997) Flies with l(1)sc^Scer\UAS.cHa under the control of Scer\GAL4^ptc-559.1 form multiple ectopic macrochaetae and microchaetae on the scutellum. l(1)sc^Scer\UAS.cHa, when driven by Scer\GAL4^ap-md544, creates a pattern of discrete sensory organ precursors randomly dispersed throughout the dorsal half of the wing pouch in the wing disc. (Apidianakis et al., 1999) Before delamination of the SI neuroblasts, the ventral neuroectoderm (VNE) of embryos expressing l(1)sc^Scer\UAS.cHa under the control of Scer\GAL4^da.G32 can be subdivided into three longitudinal regions based on average cell size, as in wild-type embryos. More enlarged cells are detected in all regions of the VNE compared to wild type; 81% in the medial, 65% in the intermediate and 71% in the lateral region (wild-type numbers are 63%, 20% and 64% respectively). The morphologies and cell sizes of the neuroblasts are altered compared to wild type; whereas in wild-type embryos the delaminating neuroblasts have small apical surfaces and are basally bloated, almost all SI neuroblasts in the VNE of embryos expressing l(1)sc^Scer\UAS.cHa under the control of Scer\GAL4^da.G32 are basally and apically bloated. As in wild-type embryos, the neuroectodermal cells that have become enlarged decrease in size during delamination of the SI neuroblasts. (Stollewerk, 2000) When l(1)sc^Scer\UAS.cHa is driven by Scer\GAL4^sca-537.4 complete ectopic mechano-sensory bristles are seen. (Nagel et al., 2000)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by emc^E12 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by emc⁰⁴³²² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by Dl⁰³⁹³⁵ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by Dl⁰⁶⁶⁰⁶ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by E(spl)^R-B251 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by h⁴¹ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by h⁰⁰⁶⁸² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by h⁰⁸²⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by mam^E343-5 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by mam^k11208 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by mam²¹ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^E227-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^E291-6 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^E470-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^X234-1 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^X253-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by ptc^X291-5 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by eIF-4a^k09406 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by Hrb27C⁰²⁶⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa^k06526 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa^k10306 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa⁰⁷⁴⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa^k10313 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa^E481-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by l(2)44DEa^E305-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by Hr46^k09242 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, enhanceable by jumu^06142a (Rottgen et al., 1998)
Suppressed by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by da^IIP106 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by da^E253-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by da^E321-6 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by da^X293-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^E222-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^E276-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^E311-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^X200-1 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^X234-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has visible phenotype, suppressible by H^X257-3 (Rottgen et al., 1998)
Phenotype Manifest In
Enhanced by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, enhanceable by E(spl)^{+,stop.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, enhanceable by E(spl)^{1,stop.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, enhanceable by E(spl)^1.Scer\UAS, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, enhanceable by E(spl)^{bHLH.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by emc^E12 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by emc⁰⁴³²² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by Dl⁰³⁹³⁵ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by Dl⁰⁶⁶⁰⁶ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by E(spl)^R-B251 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by h⁴¹ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by h⁰⁰⁶⁸² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by h⁰⁸²⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by mam^E343-5 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by mam^k11208 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by mam²¹ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^E227-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^E291-6 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^E470-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^X234-1 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^X253-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by ptc^X291-5 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by eIF-4a^k09406 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by Hrb27C⁰²⁶⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa^k06526 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa^k10306 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa⁰⁷⁴⁴⁷ (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa^k10313 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa^E481-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by l(2)44DEa^E305-3 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by Hr46^k09242 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, enhanceable by jumu^06142a (Rottgen et al., 1998)
NOT Enhanced by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, non-enhanceable by E(spl)^{ΔbHIII.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, non-enhanceable by E(spl)^P-L.Scer\UAS, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997)
Suppressed by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, suppressible by E(spl)^{ΔbHIV.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, suppressible by E(spl)^{ΔbHLH.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, suppressible by E(spl)^Scer\UAS.cGa, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by da^IIP106 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by da^E253-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by da^E321-6 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by da^X293-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H² (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^E222-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^E276-2 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^E311-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^X200-1 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^X234-4 (Rottgen et al., 1998) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle phenotype, suppressible by H^X257-3 (Rottgen et al., 1998)
NOT suppressed by
Statement Reference Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, non-suppressible by E(spl)^{ΔbHIII.Scer\UAS}, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997) Scer\GAL4^455.2, l(1)sc^Scer\UAS.cHa has scutellar bristle \| ectopic phenotype, non-suppressible by E(spl)^P-L.Scer\UAS, Scer\GAL4^455.2 (Giebel and Campos-Ortega, 1997)
NOT Suppressor of
Statement Reference l(1)sc^Scer\UAS.cHa/da^Scer\UAS.cGa, Scer\GAL4^da.G32 is a non-suppressor of embryonic nervous system phenotype of Dl::N^{ΔECN.Scer\UAS}, Scer\GAL4^da.G32 (Giebel et al., 1997) l(1)sc^Scer\UAS.cHa/da^Scer\UAS.cGa, Scer\GAL4^da.G32 is a non-suppressor of muscle founder cell phenotype of N^{int.SH.Scer\UAS}, Scer\GAL4^da.G32 (Giebel, 1999)
Other
Statement Reference Scer\GAL4^da.G32, da^Scer\UAS.cGa, l(1)sc^Scer\UAS.cHa has peripheral nervous system phenotype (Giebel, 1999, Giebel, 1999) Scer\GAL4^da.G32, da^Scer\UAS.cGa, l(1)sc^Scer\UAS.cHa has embryonic/larval somatic muscle phenotype (Giebel, 1999, Giebel, 1999) Scer\GAL4^da.G32, da^Scer\UAS.cGa, l(1)sc^Scer\UAS.cHa has Malpighian tubule tip cell phenotype (Hoch and Jackle, 1998, Hoch and Jackle, 1998)
Additional Comments
Genetic Interactions
Statement Reference One copy of da^IIP106 or a deficiency of da can suppress the wing phenotype, the presence of a third copy of da enhances the phenotype. (Hinz et al., 1994) Scer\GAL4^da.G32-mediated expression of Dl::N^{ΔECN.Scer\UAS} generates aneural embryos. Simultaneous expression of da^Scer\UAS.cGa and l(1)sc^Scer\UAS.cHa does not rescue the phenotype. (Giebel et al., 1997) Scer\GAL4^455.2-mediated expression leads to an increase in the number of scutellar bristles, on average 6 to 7 ectopic bristles can be counted. Phenotype can be suppressed by mutations of da and H and enhanced by mutations of emc, Dl, E(spl), h, mam, eIF-4a, ptc, Hrb27C, l(2)44DEa, Hr46, jumu and N. (Rottgen et al., 1998) Some embryos coexpressing l(1)sc^Scer\UAS.cHa and da^Scer\UAS.cGa under the control of Scer\GAL4^da.G32 develop multiple Malpighian tubule tip cells. (Hoch and Jackle, 1998) Co-expression of l(1)sc^Scer\UAS.cHa and da^Scer\UAS.cGa driven by Scer\GAL4^da.G32 results in minor muscle and PNS pattern formation defects and in very rare cases, muscle duplication. The addition of l(1)sc^Scer\UAS.cHa and da^Scer\UAS.cGa does not rescue the mesoderm phenotype of N^{int.SH.Scer\UAS} driven by Scer\GAL4^da.G32. (Giebel, 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	l(1)sc^Scer\UAS.cHa l(1)sc^UAS.cHa
Name Synonym	Saccharomyces cerevisiae UAS construct a of Hinz (Hinz et al., 1993)
Secondary FlyBase IDs

References ( 14 )
Research paper	Cooper et al., 2000, Dev. Biol. 221(2): 390--403 Spatially restricted factors cooperate with Notch in the regulation of Enhancer of split genes. [FBrf0127044] Nagel et al., 2000, Mech. Dev. 94(1-2): 3--12 Su(H)-independent activity of Hairless during mechano-sensory organ formation in Drosophila. [FBrf0128585] Stollewerk, 2000, Dev. Genes Evol. 210(4): 190--199 Changes in cell shape in the ventral neuroectoderm of Drosophila melanogaster depend on the activity of the achaete-scute complex genes. [FBrf0126921] Apidianakis et al., 1999, Mech. Dev. 86(1,2): 39--50 Overexpression of the m4 and malpha genes of the E(spl)-complex antagonizes notch mediated lateral inhibition. [FBrf0111325] Giebel, 1999, Mech. Dev. 86(1-2): 137--145 The Notch signaling pathway is required to specify muscle progenitor cells in Drosophila. [FBrf0111372] Jennings et al., 1999, Molec. Cell. Biol. 19(7): 4600--4610 Target specificities of Drosophila Enhancer of split basic helix-loop-helix proteins. [FBrf0108816] Hoch and Jackle, 1998, EMBO J. 17(19): 5766--5775 Kruppel acts as a developmental switch gene that mediates Notch signalling-dependent tip cell differentiation in the excretory organs of Drosophila. [FBrf0104911] Rottgen et al., 1998, Molec. gen. Genet. 257(4): 442--451 A genetic screen for elements of the network that regulates neurogenesis in Drosophila. [FBrf0101998] Giebel and Campos-Ortega, 1997, Proc. Natl. Acad. Sci. USA 94(12): 6250--6254 Functional dissection of the Drosophila enhancer of split protein, a suppressor of neurogenesis. [FBrf0093462] Giebel et al., 1997, Mech. Dev. 63(1): 75--87 Lethal of scute requires overexpression of daughterless to elicit ectopic neuronal development during embryogenesis in Drosophila. [FBrf0093461] Klein and Campos-Ortega, 1997, Development 124(16): 3123--3134 klumpfuss, a Drosophila gene encoding a member of the EGR family of transcription factors, is involved in bristle and leg development. [FBrf0098281] Hinz et al., 1994, Cell 76(1): 77--87 The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes. [FBrf0068528]
Review	Brand and Dormand, 1995, Curr. Opin. Neurobiol. 5(5): 572--578 The GAL4 system as a tool for unravelling the mysteries of the Drosophila nervous system. [FBrf0084801]
Abstract	Hinz et al., 1993, J. Neurogenet. 8: 233 Demonstration of the proneural function of lethal of scute by ectopic expression. [FBrf0076781]

Allele Dmel\l(1)scScer\UAS.cHa

Allele Dmel\l(1)sc^Scer\UAS.cHa