Allele Ecol\lacZ^dpp.BS3.0

General Information
Symbol	Ecol\lacZ^dpp.BS3.0	Species	E. coli
Name		FlyBase ID	FBal0041158
Feature type	allele	Created / Updated	2006-05-31/2006-05-31
Associated gene	Ecol\lacZ

Allele class
Mutagen	in vitro construct \| regulatory fusion
Nature of the Allele
Allele class
Mutagen	in vitro construct \| regulatory fusion (Raftery et al., 1991, Blackman et al., 1991, Heberlein et al., 1993, Capdevila et al., 1994, Kojima et al., 1994, Buratovich and Bryant, 1995, Freeland and Kuhn, 1996)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Ecol\lacZ^Hsp70Bb.-194 (Blackman et al., 1991)
Nature of the lesion	Statement Reference Ecol\lacZ expression is driven by fragment from 106.9-116.9kb of dpp, at the disk III-disk II boundary. (Raftery et al., 1991) 12kb EcoRI fragment spanning dpp region disk III--II boundary drives Ecol\lacZ expression. (Blackman et al., 1991) 10kb EcoRI fragment spanning dpp region disk III--II boundary drives Ecol\lacZ expression. (Heberlein et al., 1993) Ecol\lacZ gene expression is driven by an dpp promoter. (Capdevila et al., 1994) Construct: A dpp disc enhancer drives Ecol\lacZ expression. (Kojima et al., 1994) Ecol\lacZ gene expression is controlled by the 3' dpp enhancer. (Buratovich and Bryant, 1995) dpp promoter drives Ecol\lacZ expression. (Freeland and Kuhn, 1996)
Assay mode	In transgenic Drosophila (allele of foreign species in genome of drosophilid) (Raftery et al., 1991, Capdevila et al., 1994, Blackman et al., 1991, Kojima et al., 1994, Heberlein et al., 1993, Freeland and Kuhn, 1996, Buratovich and Bryant, 1995) Drosophila cell culture (Chen et al., 1999)
Carried in construct	P{BS3.0} (Royet and Finkelstein, 1997, Chen et al., 1997, Capdevila et al., 1994, Abzhanov et al., 2001, Chanut et al., 2002, Chern and Choi, 2002, Ghbeish and McKeown, 2002, Gorfinkiel et al., 1999, Collins, 2005, Kenyon et al., 2005, Lai et al., 2000, Pimentel and Venkatesh, 2005, Mukherjee et al., 2000, Jang et al., 2003, Wang et al., 1999, Maves and Schubiger, 1998, Yao et al., 1999, Moreno and Morata, 1999, Takeo et al., 2005, Heberlein et al., 1998, Apidianakis et al., 2001, Takahashi et al., 2005, Pickup et al., 2002, Amanai and Jiang, 2001, Dai et al., 2003, Erkner et al., 2002, Katsuyama et al., 2005, Lin et al., 2003, Ghazi et al., 2003, Cavodeassi et al., 2002, Ogden et al., 2006, de Navas et al., 2006, Pfleger et al., 2007, Jia et al., 2005, Gorfinkiel et al., 2003, Smith et al., 1993, Parker et al., 2002, Noureddine et al., 2002, Heberlein et al., 1993, Jia et al., 2002, Collier et al., 2004, Capdevila and Guerrero, 1994, Jia et al., 2003, Strutt et al., 1995, Sanicola et al., 1995, Ou et al., 2002, Bessa et al., 2002, Pan and Rubin, 1995, Martin et al., 1995, Niwa et al., 2004, Lepage et al., 1995, Li et al., 1995, Lee et al., 2002, Estella et al., 2003, Janody et al., 2004, Jarman et al., 1995, Jiang and Struhl, 1995, Heberlein et al., 1995, Cadigan et al., 2002, Belenkaya et al., 2002, Torroja et al., 2004, Mohler et al., 2000, del Alamo Rodriguez et al., 2004, Marenda et al., 2004, Calleja et al., 2000, Johnson et al., 2003, Sedkov et al., 2003, Buratovich and Bryant, 1995, Aza-Blanc et al., 2000, Heanue et al., 1999, Miletich and Limbourg-Bouchon, 2000, Mandal and Lakhotia, 1999, Treisman, 2001, Haines and van Den Heuvel, 2000, Sanchez et al., 2001, Kumar and Moses, 2001, Zeng et al., 2000, McCartney et al., 2000, Lee et al., 1994, Cho et al., 2000, Felsenfeld and Kennison, 1995, Kojima et al., 1994, Svendsen et al., 2000, Collins and Treisman, 2000, Maurel-Zaffran and Treisman, 2000, Estrada and Sanchez-Herrero, 2001, Entchev et al., 2000, Teleman and Cohen, 2000, Chanut et al., 2000, Garoia et al., 2000, Certel et al., 2000, Benlali et al., 2000, Azpiazu and Morata, 2000, Baonza et al., 2000, Greenwood and Struhl, 1999, Weigmann and Cohen, 1999, Alves et al., 1998, Kopp et al., 1999, Goto and Hayashi, 1999, Chen et al., 1999, Vervoort et al., 1999, Garoia et al., 2005, Asano and Wharton, 1999, Methot and Basler, 1999, Ho et al., 2005, Jackson et al., 1997, Dominguez and Hafen, 1997, Joulia et al., 2005, Niwa et al., 2000, Zeng and Verheyen, 2004, Strigini and Cohen, 1997, Strutt and Mlodzik, 1997, Song et al., 2000, Sanchez et al., 1997, Casares et al., 1997, Gorfinkiel et al., 1997, Weigmann et al., 1997, Randsholt et al., 2000, Pichaud and Casares, 2000, Newfeld et al., 1997, Jia et al., 2004, Zelhof et al., 1997, Nestoras et al., 1997, Buratovich and Bryant, 1997, Blackman et al., 1991, Tavsanli et al., 2004, Raftery et al., 1991, Yao et al., 2006, Bras-Pereira et al., 2006, Blair, 1992, Nakano et al., 2004, Perez-Garijo et al., 2004, Maschat et al., 1998, Lee and Treisman, 2001, Go et al., 1998, Lee et al., 2001, Saget et al., 1998, Alexandre et al., 1996, Khalsa et al., 1998, Emerald and Roy, 1998, Chanut and Heberlein, 1995, Freeland and Kuhn, 1996, Guillen et al., 1995, Sanchez-Herrero et al., 1996, Nellen et al., 1996, Abu-Shaar and Mann, 1998, Lecuit et al., 1996, Curtiss and Heilig, 1995, Theodosiou et al., 1998, Hazelett et al., 1998, Lee and Treisman, 2001, Mozer, 2001, Treisman et al., 1995, Borod and Heberlein, 1998, Treisman and Rubin, 1995, Ma and Moses, 1995, Kango-Singh et al., 2003, Ingham and Fietz, 1995, Lukacsovich et al., 2003, Simmonds et al., 1995, Strutt and Mlodzik, 1995, Weatherbee et al., 1998, Treisman et al., 1997, Schneider and Spradling, 1997, Strutt and Mlodzik, 1996, Adamson and Shearn, 1996, Lecuit and Cohen, 1997, Chanut and Heberlein, 1997, Burke and Basler, 1996, Shen and Mardon, 1997, van den Heuvel and Ingham, 1996, Chen and Baker, 1997, Mullor et al., 1997, Epps et al., 1997, Heslip et al., 1997, Kenyon et al., 2003, Pignoni and Zipursky, 1997, Morimura et al., 1996, Penton et al., 1997, Johnston and Schubiger, 1996, Chanut and Heberlein, 1997, Brook and Cohen, 1996, Jiang and Struhl, 1998, Chen and Struhl, 1996, Sturtevant et al., 1997, Pignoni et al., 1997, Gorfinkiel et al., 2005, Horabin, 2005, Stultz et al., 2006, Dussillol-Godar et al., 2006, Rogers et al., 2005, Kent et al., 2006, Wang and Struhl, 2004, Ekas et al., 2006, Zhao et al., 2007, Kugler and Nagel, 2007, Hennig et al., 2006)
Cytology
Phenotypic Data
Phenotypic Class

Phenotype Manifest In

Detailed Description
	Statement Reference
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	5527 P{BS3.0}H1-1, cn¹; ry⁵⁰⁶ 5528 cn¹; P{BS3.0}H1-2, ry⁵⁰⁶/TM2
Notes on Origin
Discoverer	Blackman

Comments
	Carried in a plasmid, expressed in cl-8 cells and used as a reporter construct to study response to hh signalling in these cells. (Chen et al., 1999)
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	BS3.0 (Chen et al., 1999) dpp^BS3.0 (Baonza et al., 2000) dpp-lacZ (Apionishev et al., 2005) Ecol\lacZ^dpp.BS3.0 lacZ^dpp.BS3.0
Name Synonym
Secondary FlyBase IDs

References ( 209 )

Generate a list of	All references relating to this allele ( 209 )

List References by type	Research paper ( 206 ) Supplementary material ( 1 ) Letter ( 2 )
Recent research papers ( 12 )
	Kugler and Nagel, 2007, Molec. Biol. Cell 18(10): 3733--3740 Putzig is required for cell proliferation and regulates notch activity in Drosophila. [FBrf0201686] Pfleger et al., 2007, Fly 1(2): 95--105 Mutation of the gene encoding the ubiquitin activating enzyme Uba1 causes tissue overgrowth in Drosophila. [FBrf0200069] Zhao et al., 2007, Nature 450(7167): 252--258 Hedgehog regulates smoothened activity by inducing a conformational switch. [FBrf0202820] Bras-Pereira et al., 2006, Development 133(21): 4145--4149 Odd-skipped genes specify the signaling center that triggers retinogenesis in Drosophila. [FBrf0192131] de Navas et al., 2006, Development 133(22): 4495--4506 The Ultrabithorax Hox gene of Drosophila controls haltere size by regulating the Dpp pathway. [FBrf0194425] Dussillol-Godar et al., 2006, Dev. Biol. 291(1): 53--66 Modulation of the Suppressor of fused protein regulates the Hedgehog signaling pathway in Drosophila embryo and imaginal discs. [FBrf0190115] Ekas et al., 2006, Development 133(23): 4721--4729 JAK/STAT signaling promotes regional specification by negatively regulating wingless expression in Drosophila. [FBrf0193730] Hennig et al., 2006, J. Cell Biol. 173(6): 963--974 TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth. [FBrf0195068] Kent et al., 2006, Development 133(10): 2001--2010 Roadkill attenuates Hedgehog responses through degradation of Cubitus interruptus. [FBrf0193969] Ogden et al., 2006, J. Biol. Chem. 281(11): 7237--7243 Smoothened regulates activator and repressor functions of Hedgehog signaling via two distinct mechanisms. [FBrf0190897] Stultz et al., 2006, Dev. Biol. 296(2): 329--339 Decapentaplegic head capsule mutations disrupt novel peripodial expression controlling the morphogenesis of the Drosophila ventral head. [FBrf0193866] Yao et al., 2006, Development 133(20): 4025--4034 Schnurri transcription factors from Drosophila and vertebrates can mediate Bmp signaling through a phylogenetically conserved mechanism. [FBrf0193712] Show all research papers ...

Allele Ecol\lacZdpp.BS3.0

Allele Ecol\lacZ^dpp.BS3.0