Allele Dmel\fng⁵²

General Information
Symbol	Dmel\fng⁵²	Species	D. melanogaster
Name		FlyBase ID	FBal0034614
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\fng

Allele class	hypomorph
Mutagen	Δ2-3, P-element activity
Nature of the Allele
Allele class	hypomorph (Irvine and Wieschaus, 1994, Cohen et al., 1997, Fleming et al., 1997, Grammont and Irvine, 2001)
Mutagen	Δ2-3 (Irvine and Wieschaus, 1994) P-element activity (Correia et al., 2003)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	fng^35UZ-1 (Correia et al., 2003) fng¹ (Irvine and Wieschaus, 1994)
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	viable (Fleming et al., 1997, Grammont and Irvine, 2001) semi-viable (Correia et al., 2003) semi-viable (with Df(3L)ri-XT1) (Correia et al., 2003) semi-viable (with fng¹²⁹) (Correia et al., 2003) semi-viable (with fng¹³) (Correia et al., 2003) semi-viable (with fng¹⁴) (Correia et al., 2003) semi-viable (with fng²) (Correia et al., 2003) semi-viable (with fng⁷) (Correia et al., 2003) semi-viable (with fng⁸) (Correia et al., 2003) semi-viable (with fng⁸⁰) (Correia et al., 2003) semi-viable (with fng^M69) (Correia et al., 2003) semi-viable (with fng^L83) (Correia et al., 2003) semi-viable (with fng^L81) (Correia et al., 2003) semi-viable (with fng^L73) (Correia et al., 2003) semi-viable (with fng^L19) (Correia et al., 2003) semi-viable (with fng⁵) (Correia et al., 2003) semi-viable (with fng³) (Correia et al., 2003) semi-viable (with fng¹) (Correia et al., 2003) semi-viable (with fng¹¹) (Correia et al., 2003) visible (Fleming et al., 1997) visible \| recessive (Cohen et al., 1997, Papayannopoulos et al., 1998, Irvine and Wieschaus, 1994)
Phenotype Manifest In
	wing (with fng^L19) (Correia et al., 2003) wing (with fng³) (Correia et al., 2003) wing (with fng⁸⁰) (Correia et al., 2003) ovary (with fng^M69) (Grammont and Irvine, 2001) egg chamber (with fng^M69) (Grammont and Irvine, 2001) interfollicle cell (with fng^M69) (Grammont and Irvine, 2001) follicle cell (with fng^M69) (Grammont and Irvine, 2001) wing (with fng^M69) (Correia et al., 2003) wing (with Df(3L)ri-XT1) (Correia et al., 2003) wing (with fng¹³) (Correia et al., 2003) wing (with fng²) (Correia et al., 2003) wing (with fng¹¹) (Correia et al., 2003) wing (with fng¹²⁹) (Correia et al., 2003) wing (with fng¹⁴) (Correia et al., 2003) wing (with fng¹) (Correia et al., 2003) wing (with fng⁵) (Correia et al., 2003) wing (with fng⁷) (Correia et al., 2003) wing (with fng⁸) (Correia et al., 2003) wing (with fng^L73) (Correia et al., 2003) wing (with fng^L81) (Correia et al., 2003) wing (with fng^L83) (Correia et al., 2003) wing (Correia et al., 2003, Fleming et al., 1997, Cohen et al., 1997, Irvine and Wieschaus, 1994) wing vein (Cohen et al., 1997) ocellar triangle (Papayannopoulos et al., 1998) eye (Papayannopoulos et al., 1998) ovary (Grammont and Irvine, 2001) egg chamber (Grammont and Irvine, 2001) follicle cell (Grammont and Irvine, 2001)
Detailed Description
	Statement Reference Loss of tissue from the wing margin. (Irvine and Wieschaus, 1994) Weak wing vein-splitting or 'delta' phenotype but a normal wing margin in heterozygotes. (Cohen et al., 1997) Reduction in wing margin formation. fng⁸⁰/fng⁵² mutants are weakly viable and exhibit a severe wing margin loss phenotype. (Fleming et al., 1997) fng⁵²/fng¹³ flies have small eyes. Tissue loss in the ocellar region is also seen. (Papayannopoulos et al., 1998) Homozygous females have ovaries showing 43% compound follicles, 18% with long stalks 82% of follicles have abnormal epithelium. Transheterozygous fng⁵²/fng^M69 females have ovaries showing 33% compound follicles and 22% of follicles have abnormal epithelium. Where follicles do not include the usual 16 germline cells, those with more than usual germline cells lie next to those with fewer than usual germline cells. Along the length of the entire ovariole the oocyte:nurse cell ratio is normal. The abnormalities of number of germline cells in each egg chamber is caused by defects in the enclosure of germline cysts by somatic follicle cells. The long stalk phenotype is sometimes accompanied by a stalk disorganization phenotype. (Grammont and Irvine, 2001) fng⁵²/Df(3L)ri-XT1 animals that survive to adulthood when grown at 18^oC exhibit a moderate wing phenotype. fng⁵²/fng⁸⁰ animals that survive to adulthood exhibit a strong wing phenotype. fng⁵²/fng¹³ animals that survive to adulthood exhibit a moderate wing phenotype. fng⁵²/fng^M69 animals that survive to adulthood when grown at 18^oC exhibit a strong wing phenotype. Homozygous fng⁵² animals that survive to adulthood exhibit a moderate wing phenotype. fng⁵²/fng² animals that survive to adulthood exhibit a weak wing phenotype. (Correia et al., 2003)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhancer of
Statement Reference fng⁵² is an enhancer of visible phenotype of Nsf2^EQ.Scer\UAS, Scer\GAL4^bbg-C96 (Stewart et al., 2001)
Phenotype Manifest In
Enhancer of
Statement Reference fng⁵² is an enhancer of wing phenotype of Mmus\Mfng^Scer\UAS.cCa, Scer\GAL4^ptc-559.1 (Cohen et al., 1997) fng⁵² is an enhancer of wing margin phenotype of Nsf2^EQ.Scer\UAS, Scer\GAL4^bbg-C96 (Stewart et al., 2001) fng⁵² is an enhancer of wing phenotype of Mmus\Rfng^Scer\UAS.cCa, Scer\GAL4^ptc-559.1 (Cohen et al., 1997)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Fails to complement	fng^M69 (Grammont and Irvine, 2001)
Comments
Stocks ( 1 )
Bloomington	9893 w^*; mwh¹ jv¹ fng⁵²/TM3, P{GAL4-Kr.C}DC2, P{UAS-GFP.S65T}DC10, Sb¹
Notes on Origin
Discoverer

Comments
	Phenotypic analysis suggests the following allelic series: fng^M69 > fng⁵² > fng². (Correia et al., 2003)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	fng⁵² frg⁵² (Stewart et al., 2001)
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Correia et al., 2003, Proc. Natl. Acad. Sci. USA 100(11): 6404--6409 Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila. [FBrf0159701] Grammont and Irvine, 2001, Development 128(12): 2243--2253 fringe and Notch specify polar cell fate during Drosophila oogenesis. [FBrf0137222] Stewart et al., 2001, Dev. Biol. 234(1): 13--23 Snare-dependent signaling at the Drosophila wing margin. [FBrf0135720] Papayannopoulos et al., 1998, Science 281(5385): 2031--2034 Dorsal-ventral signaling in the Drosophila eye. [FBrf0104775] Cohen et al., 1997, Nature Genetics 16(3): 283--288 Fringe boundaries coincide with Notch-dependent patterning centres in mammals and alter Notch-dependent development in Drosophila. [FBrf0094479] Fleming et al., 1997, Development 124(15): 2973--2981 Serrate-mediated activation of Notch is specifically blocked by the product of the gene fringe in the dorsal compartment of the Drosophila wing imaginal disc. [FBrf0094729] Panin et al., 1997, Nature 387(6636): 908--912 Fringe modulates Notch-ligand interactions. [FBrf0096031] Irvine and Wieschaus, 1994, Cell 79(4): 595--606 fringe, a boundary-specific signaling molecule, mediates interactions between dorsal and ventral cells during Drosophila wing development. [FBrf0076041]

Allele Dmel\fng52

Allele Dmel\fng⁵²