Allele Dmel\cact²⁵⁵

General Information
Symbol	Dmel\cact²⁵⁵	Species	D. melanogaster
Name		FlyBase ID	FBal0030687
Feature type	allele	Created / Updated	2006-05-14/2006-05-14
Associated gene	Dmel\cact

Allele class
Mutagen	PM hybrid dysgenesis, Δ2-3, P-element activity
Nature of the Allele
Allele class
Mutagen	PM hybrid dysgenesis (Roth et al., 1991) Δ2-3 (Geisler et al., 1992) P-element activity (Tower and Kurapati, 1994, Bergmann et al., 1996)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference P{lacZ} enhancer trap element inserted in 1st intron. (Geisler et al., 1992) P{FZ} insertion in the first intron. (Bergmann et al., 1996)
Assay mode
Caused by insertion	P{FZ}cact²⁵⁵ (Roth et al., 1991, Tower et al., 1993, Landis and Tower, 1999, Tower and Kurapati, 1994, Ashburner et al., 1999.10.12, Ashburner et al., 1999, Geisler et al., 1992, Dawson et al., 1995, Nicolas et al., 1998, Bergmann et al., 1996, Li and Baker, 1998)
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| maternal effect \| recessive (Roth et al., 1991) lethal \| recessive (Tower and Kurapati, 1994) female sterile \| recessive (Ashburner et al., 1999)
Phenotype Manifest In
	embryonic epidermis \| maternal effect (Roth et al., 1991)
Detailed Description
	Statement Reference Strong ventralizing phenotype: lack of all dorsally and laterally derived structures and the expansion of the ventral epidermis around the entire circumference. Expansion of twi expression in terminal regions. (Roth et al., 1991)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Of 20 P element-induced excisions of the P element in cact²⁵⁵, 8 had completely restored cactus function. (Geisler et al., 1992)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	cact²⁵⁵ cact^F255 (Li and Baker, 1998, Kidd, 1992)
Name Synonym
Secondary FlyBase IDs

References ( 14 )
Research paper	Landis and Tower, 1999, Development 126(19): 4281--4293 The Drosophila chiffon gene is required for chorion gene amplification, and is related to the yeast Dbf4 regulator of DNA replication and cell cycle. [FBrf0111407] Chen et al., 1998, Genetics 149(1): 157--163 Mapping of Drosophila mutations using site-specific male recombination. [FBrf0102840] Li and Baker, 1998, Development 125(2): 225--235 Her, a gene required for sexual differentiation in Drosophila, encodes a zinc finger protein with characteristics of ZFY-like proteins and is expressed independently of the sex determination hierarchy. [FBrf0100594] Nicolas et al., 1998, J. Biol. Chem. 273(17): 10463--10469 In vivo regulation of the IkappaB homologue cactus during the immune response of Drosophila. [FBrf0102368] Wu and Anderson, 1998, Nature 392(6671): 93--97 Regulated nuclear import of Rel proteins in the Drosophila immune response. [FBrf0100747] Bergmann et al., 1996, Mech. Dev. 60(1): 109--123 A gradient of cytoplasmic Cactus degradation establishes the nuclear localization gradient of the dorsal morphogen in Drosophila. [FBrf0092467] Dawson et al., 1995, J. Cell Biol. 129(3): 725--737 The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae. [FBrf0081900] Tower and Kurapati, 1994, Molec. gen. Genet. 244(5): 484--490 Preferential transposition of a Drosophila P element to the corresponding region of the homologous chromosome. [FBrf0076961] Tower et al., 1993, Genetics 133(2): 347--359 Preferential transposition of Drosophila P-elements to nearby chromosomal sites. [FBrf0058564] Geisler et al., 1992, Cell 71: 613--621 cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates. [FBrf0055573] Kidd, 1992, Cell 71: 623--635 Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. [FBrf0055575] Roth et al., 1991, Development 112: 371--388 cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. [FBrf0053786]
Supplementary material	Ashburner et al., 1999, Genetics 153(1): Table S1. P-element insertions in the Adh region. [FBrf0112150]
Personal communication to FlyBase	Ashburner et al., 1999.10.12, Adh. Adh. [FBrf0112153]

Allele Dmel\cact255

Allele Dmel\cact²⁵⁵