Allele Dmel\ap^hs.PB

General Information
Symbol	Dmel\ap^hs.PB	Species	D. melanogaster
Name	heat shock construct of Bourgouin	FlyBase ID	FBal0030503
Feature type	allele	Created / Updated	2006-08-20/2006-08-20
Associated gene	Dmel\ap

Allele class	gain of function
Mutagen	in vitro construct \| regulatory fusion
Nature of the Allele
Allele class	gain of function (Bourgouin et al., 1992)
Mutagen	in vitro construct \| regulatory fusion (Bourgouin et al., 1992, Becker et al., 1997, Benveniste et al., 1998)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference Construct: ap cDNA expression is driven by an Hsp70 promoter. (Bourgouin et al., 1992) ap is expressed under the control of a heat shock promoter. (Becker et al., 1997)
Assay mode	In transgenic Drosophila (intraspecific) (Bourgouin et al., 1992, Benveniste et al., 1998, Becker et al., 1997)
Carried in construct	P{hs-ap} (Benveniste et al., 1998, Bourgouin et al., 1992, Becker et al., 1997, Bernard et al., 2003)
Cytology
Phenotypic Data
Phenotypic Class
	visible \| conditional - heat sensitive (Blair et al., 1994)
Phenotype Manifest In
	dorsal medial muscle (Bernard et al., 2003) abdominal 2 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 3 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 4 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 5 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 6 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 7 lateral transverse muscle 1 (Bourgouin et al., 1992) abdominal 2 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 3 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 4 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 5 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 6 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 7 lateral transverse muscle 2 (Bourgouin et al., 1992) abdominal 2 lateral transverse muscle 3 (Bourgouin et al., 1992) abdominal 3 lateral transverse muscle 3 (Bourgouin et al., 1992) abdominal 4 lateral transverse muscle 3 (Bourgouin et al., 1992) abdominal 5 lateral transverse muscle 3 (Bourgouin et al., 1992) abdominal 6 lateral transverse muscle 3 (Bourgouin et al., 1992) abdominal 7 lateral transverse muscle 3 (Bourgouin et al., 1992) wing (Blair et al., 1994)
Detailed Description
	Statement Reference When 6-7 hour old embryos homozygous for ap^hs.PB were heat shocked for 45 minutes at 37^oC, two or three extra muscles appear in the position of muscles 21, 22 and 23 (which normally express ap) in segments A1 to A7. No other muscles are affected, either by being duplicated or deleted. (Bourgouin et al., 1992) Larvae which have been treated overnight with heat shocks produce adults with a variety of wing defects, ranging from nicks to wing reductions. (Blair et al., 1994) Degeneration of dorsal medial muscles occurs in ap^hs.PB flies under various heat shock regimes with the most deleterious effect of these muscles occurring when heat shocks are performed between ... (Bernard et al., 2003)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	This phenotype resembles that of the dominant ap^Xa allele. (Blair et al., 1994)
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	ap^hs.PB
Name Synonym	heat shock construct of Bourgouin
Secondary FlyBase IDs

References ( 5 )
Research paper	Bernard et al., 2003, Dev. Biol. 260(2): 391--403 Control of apterous by vestigial drives indirect flight muscle development in Drosophila. [FBrf0162051] Benveniste et al., 1998, Development 125(23): 4757--4765 Cell type-specific regulation of the Drosophila FMRF-NH2 neuropeptide gene by apterous, a LIM homeodomain transcription factor. [FBrf0106026] Becker et al., 1997, Development 124(13): 2615--2622 Reciprocal signaling between Drosophila epidermal muscle attachment cells and their corresponding muscles. [FBrf0094132] Blair et al., 1994, Development 120(7): 1805--1815 The role of apterous in the control of dorsoventral compartmentalization and PS integrin gene expression in the developing wing of Drosophila. [FBrf0072642] Bourgouin et al., 1992, Neuron 9: 549--561 Apterous is a Drosophila LIM domain gene required for the development of a subset of embryonic muscles. [FBrf0057363]

Allele Dmel\aphs.PB

Allele Dmel\ap^hs.PB