A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\rk4

General Information
SymbolDmel\rk4SpeciesD. melanogaster
NameFlyBase IDFBal0014577
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\rk
Allele class
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
spontaneous
(Lindsley and Zimm, 1992, Ashburner et al., 1999.10.12)
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
      Amino acid replacement: W954@. Nucleotide substitution: G?A.
      (Baker and Truman, 2002)
      Assay mode
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      viable
      (Lindsley and Zimm, 1992)
      viable | male | reduced
      (Lindsley and Zimm, 1992)
      visible
      (Baker and Truman, 2002)
      fertile
      (Lindsley and Zimm, 1992)
      behavior defective
      (Baker and Truman, 2002)
      mating defective
      (Lindsley and Zimm, 1992)
      mating defective | male
      (Lindsley and Zimm, 1992)
      hide Phenotype Manifest In
      wing
      (Lindsley and Zimm, 1992, Baker and Truman, 2002)
      leg
      (Lindsley and Zimm, 1992)
      adult cuticle
      (Baker and Truman, 2002)
      tarsal segment
      (Baker and Truman, 2002)
      hide Detailed Description
      Statement
      Reference
      Wings unexpanded, spread and drooping. Posterior legs malformed. Both sexes fully viable and fertile. rk4 male mates with wild-type female only if wings removed from female. Viability 60% of wild type.
      (Lindsley and Zimm, 1992)
      Body colour: homozygous flies show a delay in post-ecdysial tanning; 3 hours after eclosion, homozygous flies have not begun to darken, whereas wild-type flies have a tanned cuticle, while by 6-9 hours after eclosion the difference is no longer apparent. Homozygotes show no difference in the time course of development from the white puparium stage onwards when compared to wild-type flies. 17% of homozygotes show a flattening of the tarsi and 100% of homozygotes fail to expand their wings. Homozygotes are much more active over the first 30 minutes after eclosion compared to wild-type flies, repeatedly alternating between cleaning and walking. They do not show air swallowing behaviour or the sustained abdominal contraction characteristic of wing expansion.
      (Baker and Truman, 2002)
      hide Interactions
      hide Phenotypic Class
      hide Phenotype Manifest In
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      rk4/+ ; bursZ1091/+ double heterozygous flies show no defects in wing expansion or tanning. rk4/+ ; bursZ5569/+ double heterozygous flies show no defects in wing expansion or tanning.
      (Dewey et al., 2004)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 2 )
      Bloomington
      3590
      rk4
      Kyoto
      107114
      rk4
      hide Notes on Origin
      Discoverer
      R.C. Jackson, Mar. 1954
      Jackson, March 1954.
      hide Synonyms & Secondary IDs ( 3 )
      Reported As
      Symbol Synonym
      cq
      (Lindsley and Zimm, 1992)
      rk4
      (Christensen and Cook, 2007.3.22, Christensen and Cook, 2007.3.22)
      Name Synonym
      creeper
      (Lindsley and Zimm, 1992)
      Secondary FlyBase IDs
        hide References ( 10 )
        Research paper
        Dewey et al., 2004, Curr. Biol. 14(13): 1208--1213
        Identification of the gene encoding bursicon, an insect neuropeptide responsible for cuticle sclerotization and wing spreading. [FBrf0179185]
        Baker and Truman, 2002, J. exp. Biol. 205(17): 2555--2565
        Mutations in the Drosophila glycoprotein hormone receptor, rickets, eliminate neuropeptide-induced tanning and selectively block a stereotyped behavioral program. [FBrf0151390]
        Gubb et al., 1988, Genetics 119: 377--390
        A selective screen to recover chromosomal deletions and duplications in Drosophila melanogaster. [FBrf0048206]
        Burdick, 1961, D. I. S. 35: 45
        [New mutants report.] [FBrf0063342]
        Meyer, 1958, D. I. S. 32: 83
        [New mutants report.] [FBrf0063690]
        Jackson, 1954, D. I. S. 28: 74
        [New mutants report.] [FBrf0063547]
        Personal communication to FlyBase
        Christensen and Cook, 2007.3.22, Isolation and characterization of Df(2L)BSC252.
        Isolation and characterization of Df(2L)BSC252. [FBrf0199241]
        Christensen and Cook, 2007.3.22, Isolation and characterization of Df(2L)BSC253.
        Isolation and characterization of Df(2L)BSC253. [FBrf0199250]
        Ashburner et al., 1999.10.12, Adh.
        Adh. [FBrf0112153]
        Book
        Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster.
        The Genome of Drosophila melanogaster. [FBrf0066905]