Allele Dmel\qs²

General Information
Symbol	Dmel\qs²	Species	D. melanogaster
Name		FlyBase ID	FBal0014146
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\qs

Allele class
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class
Mutagen	ethyl methanesulfonate (Lindsley and Zimm, 1992)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	viable \| conditional - cold sensitive (Pentz et al., 1990) viable \| male (Pentz et al., 1990) semi-viable \| female \| recessive (Pentz et al., 1990) lethal \| recessive (Pentz et al., 1990)
Phenotype Manifest In
	adult cuticle \| male (Pentz et al., 1990) macrochaeta & adult \| male (Pentz et al., 1990) puparium (Pentz et al., 1990)
Detailed Description
	Statement Reference Mutation is leaky, some hemizygous males survive. Viability of these males is reduced at 18^oC. Male adult cuticle and bristles are very pale with a yellowish cast. Pupae cases are also very pale. Recovered as suppressor of b; cold-sensitive in males and females. At 25^oC, qs²/qs² females only 1% viable but qs²/Y males as viable as wild type. (Pentz et al., 1990)
Interactions
	Show the genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Suppressor of
Statement Reference qs² is a suppressor of phenotype of b^74b4 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^71k2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76f3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83d35 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81c17 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c36 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83d29b (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78k2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76k1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d8 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83f51 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83d36 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79a4 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81a2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77a3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74c4 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^84g (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78g (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d10 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74d6 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77a1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^84h34 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74c5 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83l (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76j2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81c2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d4 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78k1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76e2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77j (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76e1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78k5 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79h2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76b1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74c2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83f17 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^82c3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79df2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79b7 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77a4 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77a2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79b1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79g2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d11 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^82c7 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c20 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^75a (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78f2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83f18 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b⁶⁶¹ (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83b40 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78a (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c25 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^77a5 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83f52 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78k3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79h3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^79d13 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^76k2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c47 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74b5 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^78f1 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81c (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c26 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^74b2 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81k (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^81f3 (Alexandrov and Alexandrova, 1986) qs² is a suppressor of phenotype of b^83c35b (Alexandrov and Alexandrova, 1986)
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 2 )
Bloomington	4348 qs²/FM6
Kyoto	107698 qs²/FM6
Notes on Origin
Discoverer	Sherald.

Comments
	Mutation decreases phenol oxidase activity. The thermolabile profile suggest that the thermostable component is absent or altered. At 60^oC both the qs² activators are inactivated within 2 minutes. A large build up of the DOPA pool suggests the function that produces DOPA may not be affected. The catecholamine pool size is reduced. (Pentz et al., 1990)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	qs² su(b)¹⁸ (The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Alexandrov and Alexandrova, 1986) su¹⁸ (Lindsley and Zimm, 1992)
Name Synonym
Secondary FlyBase IDs

References ( 6 )
Research paper	Pentz et al., 1990, Biochem. Genet. 28(3/4): 151--171 Mutations affecting phenol oxidase activity in Drosophila: quicksilver and tyrosinase-1. [FBrf0051216] Alexandrov and Alexandrova, 1986, D. I. S. 63: 159--161 Report of new mutants. [FBrf0044054] Sherald, 1981, Molec. gen. Genet. 183: 102--106 Intergenic suppression of the black mutation of Drosophila melanogaster. [FBrf0037053]
Review	Wright, 1987, Adv. Genet. 24: 127--222 The genetics of biogenic amine metabolism, sclerotization, and melanization in Drosophila melanogaster. [FBrf0045547]
Stock list	The Moscow Regional Drosophila melanogaster Stock Center, Dubna, Russia, 1997, D. I. S. 80: 109--130 Stock list. [FBrf0098381]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Allele Dmel\qs2

Allele Dmel\qs²