A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Allele Dmel\e1

General Information
SymbolDmel\e1SpeciesD. melanogaster
NameFlyBase IDFBal0003278
Feature typealleleCreated / Updated2006-08-22/2006-08-22
Associated geneDmel\e
Allele class
Mutagenspontaneous
hide Nature of the Allele
Allele class
Mutagen
spontaneous
 
Mapped Features and Mutations
Type
Symbol & Location
Additional Notes
References
 
 
 
 
Associated Sequence Data
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Progenitor genotype
      Nature of the lesion
      Statement
      Reference
       
       
      Assay mode
      Carried on aberration
      TM3-P{Δ2-3}
      (FlyBase Curators, 2006-)
      TM3
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16)
      TM3βT8
      (FlyBase Curators, 2006-)
      TM6B-22UZ
      (FlyBase Curators, 2006-)
      TM6-vYa
      (FlyBase Curators, 2006-)
      TM3-HBL1.1
      (FlyBase Curators, 2006-)
      TM3-vKb
      (FlyBase Curators, 2006-)
      TM3-vKc
      (FlyBase Curators, 2006-)
      TM3-vCd
      (FlyBase Curators, 2006-)
      TM3-HShid
      (FlyBase Curators, 2006-)
      TM6B-UZ
      (FlyBase Curators, 2006-)
      In(3LR)TM6B
       
      TM3-DZ
      (FlyBase Curators, 2006-)
      TM3-lacZ-hg
      (FlyBase Curators, 2006-)
      TM6B,abdA-LacZ
      (FlyBase Curators, 2006-)
      TM3-vSb
      (FlyBase Curators, 2006-)
      TM3-vCe
      (FlyBase Curators, 2006-)
      TM6bT8LZ
      (FlyBase Curators, 2006-)
      TM6B-vHa
      (FlyBase Curators, 2006-)
      TM6C-vSa
      (FlyBase Curators, 2006-)
      In(3LR)TM6C
       
      TM3-vKd
      (FlyBase Curators, 2006-)
      TM3-Pw+-lacZ
      (FlyBase Curators, 2006-)
      TM6B-vGb
      (FlyBase Curators, 2006-)
      TM3-ftz-lacZ
      (FlyBase Curators, 2006-)
      TM3-vTa
      (FlyBase Curators, 2006-)
      TM3-vMa
      (FlyBase Curators, 2006-)
      TM3-vMb
      (FlyBase Curators, 2006-)
      TM3-vMc
      (FlyBase Curators, 2006-)
      TM3-vMd
      (FlyBase Curators, 2006-)
      TM3-P{ftz/lacZ}
      (FlyBase Curators, 2006-)
      TM6AbdA-lacZ
      (FlyBase Curators, 2006-)
      TM3-vGa
      (FlyBase Curators, 2006-)
      TM3-vSa
      (FlyBase Curators, 2006-)
      TM3-SC143
      (FlyBase Curators, 2006-)
      TM6B-vDAa
      (FlyBase Curators, 2006-)
      TM6B-P{Crew}
      (FlyBase Curators, 2006-)
      TM3-4
      (FlyBase Curators, 2006-)
      TM3-5
      (FlyBase Curators, 2006-)
      TM3-P{UAS-Dl.DN}
      (FlyBase Curators, 2006-)
      TM3-3-10
      (FlyBase Curators, 2006-)
      TM3-GMRargos
      (FlyBase Curators, 2006-)
      TM3-GTY
      (FlyBase Curators, 2006-)
      TM3-STY
      (FlyBase Curators, 2006-)
      TM6B-y+
      (FlyBase Curators, 2006-)
      TM6-23
      (FlyBase Curators, 2006-)
      TM6-UW23-1
      (FlyBase Curators, 2006-)
      TM3-P{ey-FLP.B}3.1
      (FlyBase Curators, 2006-)
      TM3-TCAG
      (FlyBase Curators, 2006-)
      TM3-TCAGB
      (FlyBase Curators, 2006-)
      TM3-TTG
      (FlyBase Curators, 2006-)
      TM6B-P{HZ2.7}3
      (FlyBase Curators, 2006-, Beitel, 2004.9.21)
      TM6B-P{Dfd-EYFP}3
      (FlyBase Curators, 2006-)
      TM3-vCa
      (FlyBase Curators, 2006-)
      TM6B-tub-Gal80
      (FlyBase Curators, 2006-)
      TM6-Ubx+
      (FlyBase Curators, 2006-)
      TM3-P{ftz/lacC}SC1
      (FlyBase Curators, 2006-)
      TM6C-ST
      (FlyBase Curators, 2006-)
      TM6B-vGa
      (FlyBase Curators, 2006-)
      TM6B-ryCBTb1
      (FlyBase Curators, 2006-)
      TM6C-ca1
      (FlyBase Curators, 2006-)
      Df(3R)Antp-X2
       
      TM6C-cu1
      (FlyBase Curators, 2006-)
      TM3-krS
      (FlyBase Curators, 2006-)
      TM6B-Tb
       
      TM3-T2B
      (FlyBase Curators, 2006-)
      TM6B-Tb+ca1
      (FlyBase Curators, 2006-)
      CyO-TM3-GFP
      (FlyBase Curators, 2006-)
      TM3-rSS
      (FlyBase Curators, 2006-)
      TM3-St
      (FlyBase Curators, 2006-)
      TM3-ca
      (FlyBase Curators, 2006-)
      TM6B-TD
      (FlyBase Curators, 2006-)
      Df(3L)BSC14
      (Deal and Cook, 2002.2.24)
      TM6B-BT
      (FlyBase Curators, 2006-)
      TM3-Sr
      (FlyBase Curators, 2006-)
      SM6a-TM6B
      (FlyBase Curators, 2006-)
      TM3-vSd
      (FlyBase Curators, 2006-)
      TM6B-ryCBTb+
      (FlyBase Curators, 2006-)
      TM3-AS
      (FlyBase Curators, 2006-)
      TM6-Est-CS
      (FlyBase Curators, 2006-)
      TM3-Sb
      (FlyBase Curators, 2006-)
      TM6B-ryCB
      (FlyBase Curators, 2006-)
      Df(3L)BSC15
      (Deal and Cook, 2002.2.24)
      TM6-su(Hw)5
      (FlyBase Curators, 2006-)
      TM3-ry
      (FlyBase Curators, 2006-)
      TM3-D6
      (FlyBase Curators, 2006-)
      TM6-h1
      (FlyBase Curators, 2006-)
      TM3-ISPSAS
      (FlyBase Curators, 2006-)
      TM8
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM6B-gT
      (FlyBase Curators, 2006-)
      TM6-y+
      (FlyBase Curators, 2006-)
      Df(3L)BSC33
      (Andrade and Cook, 2003.4.2)
      TSTL14
      (FlyBase Curators, 2006-)
      TM3-rS
      (FlyBase Curators, 2006-)
      TM6C-cSc
      (FlyBase Curators, 2006-)
      TM6-IdhS
      (FlyBase Curators, 2006-)
      TM6B.Scr-lacZ
      (FlyBase Curators, 2006-)
      TM3-vCb
      (FlyBase Curators, 2006-)
      F(3R)1
       
      TM3-P{sevRas1.V12}FK2
      (FlyBase Curators, 2006-)
      TM3-vMe
      (FlyBase Curators, 2006-)
      TM6B-P
      (FlyBase Curators, 2006-)
      TM3-SbSer
      (FlyBase Curators, 2006-)
      TM3-rsuS
      (FlyBase Curators, 2006-)
      TM3-vSc
      (FlyBase Curators, 2006-)
      Df(3R)LIN
      (Johnston et al., 1998)
      TM3-pAct-GFP
      (FlyBase Curators, 2006-)
      TM6B-D
       
      Df(3L)BSC13
      (Deal and Cook, 2002.2.25)
      CyO-TM9
      (FlyBase Curators, 2006-)
      TM3-GFP
      (FlyBase Curators, 2006-)
      TM6B-rT
      (FlyBase Curators, 2006-)
      TM6C-AST
      (FlyBase Curators, 2006-)
      TSTL
      (FlyBase Curators, 2006-)
      TM6C-Sb1
      (FlyBase Curators, 2006-)
      TM3-P{ftz-lacZ.ry+}TM3
      (FlyBase Curators, 2006-)
      TM3-P{GAL4-Hsp70.PB}TR2,P{UAS-GFP.Y}TR2
      (FlyBase Curators, 2006-)
      TM6B-rTc
      (FlyBase Curators, 2006-)
      Df(3L)BSC46
      (Andrade and Cook, 2003.12.11)
      TM6B-Dl
      (FlyBase Curators, 2006-)
      TM3-HoP3B
      (FlyBase Curators, 2006-)
      TM3-UbxD105.17
      (FlyBase Curators, 2006-)
      TM3-ArSS
      (FlyBase Curators, 2006-)
      TM3-P{UAS-y.C}MC2
      (FlyBase Curators, 2006-)
      TM3-P{UAS-Dl.DN}TJ1
      (FlyBase Curators, 2006-)
      TM6B
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992, Bloomington Drosophila Stock Center, 1998.5.16)
      TM6B-Tb+
      (FlyBase Curators, 2006-)
      TM6B-Dup99BTM6B
      (FlyBase Curators, 2006-)
      Df(3L)BSC23
      (Deal et al., 2002.11.12)
      TM3-rrSS
      (FlyBase Curators, 2006-)
      TM6-EEFLAT
      (FlyBase Curators, 2006-)
      TM6C-ryCB
      (FlyBase Curators, 2006-)
      TM9
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM3-p+Sb1
      (FlyBase Curators, 2006-)
      TM3-P{35UZ}2
      (FlyBase Curators, 2006-)
      Df(3L)BSC35
      (Andrade and Cook, 2003.6.2)
      Df(3L)BSC12
      (Deal and Cook, 2002.1.22)
      TM6C
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM3-Thb8
      (FlyBase Curators, 2006-)
      TM6B-Tc
      (FlyBase Curators, 2006-)
      TM3-vKa
      (FlyBase Curators, 2006-)
      TM6B-Sb1
      (FlyBase Curators, 2006-)
      TM3-mwh2-ru1
      (FlyBase Curators, 2006-)
      TM6B-pXp
      (FlyBase Curators, 2006-)
      TM3-Ser
      (FlyBase Curators, 2006-)
      CyO-TM6B
      (FlyBase Curators, 2006-)
      TM6
      (FlyBase Curators, 2006-, Lindsley and Zimm, 1992)
      TM6-Ue
      (FlyBase Curators, 2006-, Bloomington Drosophila Stock Center, 2001.8.28)
      Cytology
      hide Phenotypic Data
      hide Phenotypic Class
      visible
      (True et al., 1999)
      body color defective
      (Wittkopp et al., 2002, True et al., 1999)
      locomotor rhythm defective
      (Newby and Jackson, 1991)
      hide Phenotype Manifest In
      adult cuticle
      (Wittkopp et al., 2002)
      wing
      (True et al., 1999)
      synaptic vesicle
      (Borycz et al., 2002)
      hide Detailed Description
      Statement
      Reference
      Body colour: dark.
       
      A large fraction of homozygotes are arrhythmic with respect to locomotor activity when kept in constant darkness at 24oC, and the average signal-to-noise ratio (SNR) is lower than wild-type. Heterozygotes have intermediate SNR values between homozygotes and wild-type, indicating that their rhythmicity is not completely normal. Homozygotes usually show disorganised bouts of activity when transferred from a light-dark cycle to constant darkness. At 20oC, most homozygotes have weak rhythmicity or are arrhythmic, at 28oC, most homozygotes have significant periodicity. The circadian period tends to be shorter at 20oC and longer at 28oC. Some homozygotes have extremely weak rhythms under a light-dark cycle. Hemizygous e1/Df(3R)e-BS2 or e1/Df(3R)e-N19 flies show variable rhythmicity in constant darkness at 20oC and do not synchronise normally to light-dark cycles, similar to homozygotes. In contrast to homozygotes however, they do not show short-period rhythms at 20oC. norpA7 and norpA36 partially suppress the arrhythmicity of some homozygous e1 flies. The eclosion rhythm is normal.
      (Newby and Jackson, 1991)
      N-Β-alanyldopamine levels are drastically reduced in homozygous flies compared to wild-type, while dopamine levels are elevated approximately twofold. When e1 pharate adult tissue is incubated with dopamine in vitro, the extent of inducible pigmentation of body cuticle, hairs and bristle sockets resembles that of wild-type, while pigmentation of the bristle shafts is significantly reduced.
      (Walter et al., 1996)
      When e1 is combined with either rhove-1 or Vno1, in which wing veins are truncated or eliminated, ectopic melanin only develops in proximity to the veins that remain.
      (True et al., 1999)
      A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. e1 mutants retain a distinct pugment stripe and the cuticle anterior to the stripe is much darker than wild-type. In the thorax and wings, wild-type flies have a uniform colour. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen.
      (Wittkopp et al., 2002)
      There are fewer synaptic vesicles per R1-R6 photoreceptor terminal in e1 mutants than in wild type.
      (Borycz et al., 2002)
      hide Interactions
      hide Phenotypic Class
      hideEnhancer of
      Statement
      Reference
      e1 is an enhancer of body color defective phenotype of Scer\GAL4pnr-MD237, yScer\UAS.cCa
      (Wittkopp et al., 2002)
      hideOther
      Statement
      Reference
      e1, y1 has body color defective phenotype
      (Wittkopp et al., 2002, Wittkopp et al., 2002)
      hide Phenotype Manifest In
      hideOther
      Statement
      Reference
      e1, y1 has adult cuticle phenotype
      (Wittkopp et al., 2002, Wittkopp et al., 2002)
      hide Additional Comments
      hide Genetic Interactions
      Statement
      Reference
      A stripe of dark pigment seen in wild-type adult females near the posterior edge of abdominal segments A2-A6. y1, e1 double mutants have brown pigment throughout the abdomen and the stripe is no longer distinct. In the thorax and wings, wild-type flies have a uniform colour. In y1 mutants these structures become tan. In e1 mutants the thorax and wings become more darkly pigmented, and new pigmentation patterns are seen. y1, e1 double mutants also show these patterns, but the black pigment is absent, and they consist of two shades of brown pigment.
      (Wittkopp et al., 2002)
      hide Xenogenetic Interactions
      Statement
      Reference
      hide Complementation & Rescue Data
      Comments
      hide Stocks ( 740 )
      Bloomington
      1658
      e1
      2552
      pp e1
      1669
      se1 e1
      1662
      red1 e1
      738
      kniri-1 e1
      3289
      e1 tsl4/TM1
      6157
      Df(3L)D-5rv12, e1/TM2
      Kyoto
      106436
      e1
      106441
      se1 e1
      106437
      red1 e1
      106960
      e1 tsl4/TM1
      108653
      Df(3L)D-5rv12, e1/TM2
      hide Notes on Origin
      Discoverer
      Arose on: In(3R)C (inseparable).
      (Craymer, 1980)
      hide Comments
      Mutants are unable to synthesize β-alanyl-dopamine; they are deficient for the activity of β-alanyl-dopamine-synthase.
      (Perez et al., 1997)
      Mutants have reduced amounts of histamine in the head.
      (Borycz et al., 2002)
      hide Synonyms & Secondary IDs ( 1 )
      Reported As
      Symbol Synonym
      e1
       
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 25 )
        Generate a list of
        List References by type
        hide Recent research papers (0)
        All research papers listed in FlyBase were published before 2006
        Show research papers ...