Allele Dmel\Ddc⁸

General Information
Symbol	Dmel\Ddc⁸	Species	D. melanogaster
Name		FlyBase ID	FBal0002257
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\Ddc

Allele class	amorph
Mutagen	ethyl methanesulfonate
Nature of the Allele
Allele class	amorph (Wright et al., 1981)
Mutagen	ethyl methanesulfonate (Wright et al., 1976, Wright et al., 1981, Wright et al., 1982)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Wright et al., 1982, Wright et al., 1976) lethal \| partially (with Ddc⁵) (Bishop et al., 1999) lethal \| partially (with Ddc^DE1) (Bishop et al., 1999)
Phenotype Manifest In
	macrochaeta (Wright et al., 1976) cuticle (Wright et al., 1976) axillary sclerite (Wright et al., 1976)
Detailed Description
	Statement Reference Specific DDC activity of newly eclosed adult CyO/Ddc heterozygotes, as percentage of CyO/+ control: 39.6 Adult escapers of the lethality show prolonged development time and die within 24 hours of eclosion, their bristles are thin and straw coloured, and body does not darken, the wing axillae are melanized similar to the mutant phenotype of sp, the leg joints are melanized similar to a wound reaction, and they walk on their tibia rather than their tarsi, although they are coordinated. (Wright et al., 1976) Ddc^ts1 heterozygotes with Ddc null alleles show temperature-dependent sterility. (Wright et al., 1981) Ddc⁵/Ddc⁸ and Ddc⁸/Ddc^DE1 flies show partial lethality. (Bishop et al., 1999)
Interactions
Phenotypic Class
NOT suppressed by
Statement Reference Ddc⁸/Ddc⁵ has lethal \| partially phenotype, non-suppressible by Tcr⁴⁵ (Bishop et al., 1999) Ddc^DE1/Ddc⁸ has lethal \| partially phenotype, non-suppressible by Tcr⁴⁵ (Bishop et al., 1999)
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference The partial lethality seen in Ddc⁵/Ddc⁸ and Ddc⁸/Ddc^DE1 flies is not substantially rescued by Tcr⁴⁵. (Bishop et al., 1999)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	Wright.

Comments
	Alleles of Ddc show intracistronic complementation. Ddc⁵ complements Ddc¹, Ddc², Ddc³, Ddc⁴, Ddc⁵, Ddc⁶ and Ddc⁸, and all complementary combinations involve Ddc⁵ or Ddc⁸. (Wright et al., 1976) Certain combinations of Ddc alleles show intragenic complementation. (Wright et al., 1982)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Ddc⁸ Ddcⁿ⁸ (Bishop et al., 1999, Wright et al., 1982, Wright et al., 1981, Wright et al., 1976, ) l(2)E143
Name Synonym
Secondary FlyBase IDs
	FBal0042498
References ( 5 )
Research paper	Bishop et al., 1999, Genetica 105(2): 117--124 Cytological location and further characterization of the third chromosome resistance gene in Drosophila melanogaster. [FBrf0111805] Stathakis et al., 1995, Genetics 141(2): 629--655 The genetic and molecular organization of the Dopa decarboxylase gene cluster of Drosophila melanogaster. [FBrf0084402] Wright et al., 1982, Molec. gen. Genet. 188: 18--26 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0064843] Wright et al., 1981, Dev. Genet. 2(3): 223--235 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0036226] Wright et al., 1976, Genetics 84: 287--310 The genetics of dopa decarboxylase in Drosophila melanogaster. [FBrf0028753]

Allele Dmel\Ddc8

Allele Dmel\Ddc⁸