Allele Dmel\Dll¹⁷

General Information
Symbol	Dmel\Dll¹⁷	Species	D. melanogaster
Name		FlyBase ID	FBal0001014
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\Dll

Allele class	amorph
Mutagen	X ray
Nature of the Allele
Allele class	amorph (Cohen and Jurgens, 1989, Cohen et al., 1993)
Mutagen	X ray (Cohen and Jurgens, 1989)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype
Nature of the lesion	Statement Reference about 6 kb deletion around about 120 kb; removes middle exon; Coordinates estimated from Cohen, Broenner, Kuettner, Jurgens and Jaeckle (1989); origin undefined; positive values extend to left. 5.5kb deletion removing the exon encoding the amino terminal two thirds of the homeodomain. (Cohen et al., 1993)
Assay mode
Cytology
Phenotypic Data
Phenotypic Class
	lethal \| recessive (Gorfinkiel et al., 1999) lethal \| pharate adult stage \| recessive (Dong et al., 2000) visible \| recessive (Campbell and Tomlinson, 1998) visible \| recessive \| somatic clone (Gorfinkiel et al., 1999) visible \| homeotic \| recessive (Dong et al., 2000) visible \| somatic clone (Moreno and Morata, 1999, Wu and Cohen, 1999, Gorfinkiel et al., 1997)
Phenotype Manifest In
	leg \| somatic clone (Campbell and Tomlinson, 1998, Gorfinkiel et al., 1997) wing margin bristle \| cell autonomous \| somatic clone (Campbell and Tomlinson, 1998) adult cuticle \| somatic clone (Moreno and Morata, 1999) anal plate \| somatic clone (Moreno and Morata, 1999) tarsal segment \| somatic clone (Wu and Cohen, 1999, Gorfinkiel et al., 1997) ventral thoracic disc \| somatic clone (Wu and Cohen, 1999, Gorfinkiel et al., 1997) trochanter \| somatic clone (Gorfinkiel et al., 1997) tibia \| somatic clone (Gorfinkiel et al., 1997) femur \| somatic clone (Gorfinkiel et al., 1997) tibia \| proximal \| somatic clone (Gorfinkiel et al., 1997) macrochaeta & leg \| somatic clone (Gorfinkiel et al., 1997) mesothoracic femoral bract \| somatic clone (Gorfinkiel et al., 1997) mesothoracic tibial bract \| somatic clone (Gorfinkiel et al., 1997) metathoracic femoral bract \| somatic clone (Gorfinkiel et al., 1997) metathoracic tibial bract \| somatic clone (Gorfinkiel et al., 1997) prothoracic femoral bract \| somatic clone (Gorfinkiel et al., 1997) prothoracic tibial bract \| somatic clone (Gorfinkiel et al., 1997) antennal segment 2 \| somatic clone (Gorfinkiel et al., 1997) antennal segment 3 \| somatic clone (Gorfinkiel et al., 1997) arista \| somatic clone (Gorfinkiel et al., 1997) dorsal triple row \| somatic clone (Gorfinkiel et al., 1997) medial triple row \| somatic clone (Gorfinkiel et al., 1997) ventral triple row (Gorfinkiel et al., 1997) dorsal double row \| somatic clone \| somatic clone (Gorfinkiel et al., 1997) ventral double row \| somatic clone (Gorfinkiel et al., 1997) wing vein \| somatic clone (Gorfinkiel et al., 1997) wing vein \| cell non-autonomous \| somatic clone (Gorfinkiel et al., 1997) wing \| posterior compartment \| somatic clone (Gorfinkiel et al., 1997) wing \| anterior compartment \| somatic clone (Gorfinkiel et al., 1997) wing & macrochaeta \| somatic clone (Gorfinkiel et al., 1997) anal plate \| male \| somatic clone (Gorfinkiel et al., 1999) epiproct \| female \| somatic clone (Gorfinkiel et al., 1999) antennal segment 3 (Dong et al., 2000) arista (Dong et al., 2000) antenna (Dong et al., 2000) leg (Dong et al., 2000) tibia (Dong et al., 2000) femur (Dong et al., 2000) distiproboscis \| somatic clone (Yasunaga et al., 2006)
Detailed Description
	Statement Reference Greatly reduced femur and tibia, associated with normal trochanter and coxa. (Cohen et al., 1989) Wnt5 expression in head and thoracic segments is absent in embryos presumed to be homozygous for this allele. (Eisenberg et al., 1992) Dll null mutant embryos produced both leg and imaginal discs following in vivo culture. (Cohen et al., 1993) Embryos have normal mouth hooks and ventral organs, but missing an average of 5 cirri from the anterior row and 7 cirri from the posterior row. Also the ventral organ often includes extra papillae of unknown origin. (O'Hara et al., 1993) Homozygous clones induced in the leg discs do not proliferate. Homozygous clones induced in the leg during the first and second larval instar stages are only found in the pleural and coxa regions and produce no morphological abnormalities. Homozygous clones induced in the leg during the third larval instar stage are frequently seen in the distal regions of the leg. The majority of clones in the trochanter and tibia-tarsus region form vesicles that invaginate inside the appendage. These clones often contain bristles and trichomes that do not resemble those in the vicinity of the clone. Clones in the femur and proximal tibia contain bristles without bracts. Homozygous clones induced in the antenna during the first larval instar stage are able to differentiate the aI antennal segment and a small part of the aII antennal segment, but are unable to form the rest of the aII segment, segment aIII or the arista. Homozygous clones induced in the antenna during the third larval instar stage tend to form vesicles that are separated from the surrounding tissue in segments aII and aIII. Clones in the arista often differentiate bracted bristles, suggesting an antennal to leg transformation. Homozygous clones induced in the wing during the larval stage affect the wing margin; the triple row of bristles in the anterior compartment and the double row of long hairs in the posterior compartment are eliminated. Clones away from the margin often affect vein differentiation in the vicinity of the margin. This affect can be nonautonomous as wild-type cells in the vicinity of the clone are often affected. The clones develop socketed bristles in the posterior compartment and also develop a halo of pigment. (Gorfinkiel et al., 1997) Homozygous clones can be recovered in the dorsal femur when they are generated at any stage in development (from embryo to mid-third instar larva), although early in development their frequency is reduced compared to wild-type clones. When the leg is composed almost entirely of Dll¹⁷ tissue then the region more distal to the coxa is represented by only a small stump of tissue. The characteristic hairs and bristles found at the wing margin are deleted in homozygous clones at the margin. The effect of these clones is autonomous. (Campbell and Tomlinson, 1998) The distribution of homozygous clones along the proximodistal axis of the leg differs from the distribution of control clones; the ratio of distal-to-proximal clones is 2:1 for control clones and 1:4 for homozygous Dll¹⁷ clones, suggesting that homozygous Dll¹⁷ clones are lost distally. Homozygous clones in the tarsal segments segregate out of the surrounding wild-type imaginal disc epithelium. Vesicles of homozygous Dll¹⁷ tissue are sometimes seen inside the tarsal segments of the legs of adult flies. (Wu and Cohen, 1999) Dll¹⁷ somatic clones do not develop anal plates in males, or dorsal anal plates in females. Clones do not show any detectable alterations in the male external genitalia. Clones do not affect the development of the female ventral anal plates. (Gorfinkiel et al., 1999) Dll¹⁷ somatic clones produce areas of defective cuticle and are unable to form anal plates. (Moreno and Morata, 1999) Dll³/Dll¹⁷ animals die as pharate adults. They show truncations of the antenna, such as deletion of antennal segment 3 and the arista. A complete loss of the tarsal segments and shortening of both the femur and tibia is seen in the legs. (Dong et al., 2000) The basal capsule of the arista is almost normal in heterozygous flies. (Emerald et al., 2003) Large minute clones of Dll[17] result in almost all portions of distiproboscis being eliminated. The mediproboscis is not eliminated by these clones. (Yasunaga et al., 2006)
Interactions
Phenotypic Class
Other
Statement Reference Df(3R)ex56, Dll¹⁷ has visible phenotype (Emerald et al., 2003) Dll¹⁷, danr^ex35 has visible phenotype (Emerald et al., 2003, Emerald et al., 2003)
Phenotype Manifest In
Other
Statement Reference Df(3R)ex56, Dll¹⁷ has basal cylinder phenotype (Emerald et al., 2003) Df(3R)ex56, Dll¹⁷ has tarsal segment \| ectopic phenotype (Emerald et al., 2003) Dll¹⁷, danr^ex35 has basal cylinder phenotype (Emerald et al., 2003, Emerald et al., 2003) Dll¹⁷, danr^ex35 has tarsal segment \| ectopic phenotype (Emerald et al., 2003, Emerald et al., 2003)
Additional Comments
Genetic Interactions
Statement Reference Dll¹⁷ danr^ex35 or Dll¹⁷ Df(3R)ex56 double heterozygotes show ectopic tarsal bristles in the basal capsule of the arista. (Emerald et al., 2003)
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer

Comments
	Strong Dll allele. (Cohen et al., 1989) Clonal analysis indicates that the requirement for Dll in the femur and most of the tibia is lost by about the early third larval instar stage. (Campbell and Tomlinson, 1998)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Ba¹⁷ (Lindsley and Zimm, 1992) Ba^SA1 (Cohen et al., 1993, Lindsley and Zimm, 1992) Df(2R)SA1 Dll¹⁷ Dll^SA1 (Emerald and Cohen, 2004, Estella et al., 2003, Galindo et al., 2002, Emerald et al., 2003, Chu et al., 2002, Rauskolb, 2001, Dong et al., 2001, Estrada and Sanchez-Herrero, 2001, Kojima et al., 2000, Dong et al., 2000, Erkner et al., 1999, Moreno and Morata, 1999, Gorfinkiel et al., 1999, Wu and Cohen, 1999, Campbell and Tomlinson, 1998, Abu-Shaar and Mann, 1998, Gonzalez-Crespo et al., 1998, Gorfinkiel et al., 1997, O'Hara et al., 1993, Eisenberg et al., 1992, Cohen et al., 1991, Cohen and Jurgens, 1989, Cohen et al., 1989, Yasunaga et al., 2006) DllSA1 (Dong et al., 2002)
Name Synonym
Secondary FlyBase IDs
	FBab0002035
References ( 29 )

Generate a list of	All references relating to this allele ( 29 )

List References by type	Research paper ( 26 ) Supplementary material ( 1 ) Letter ( 1 ) Book ( 1 )
Recent research papers ( 1 )
	Yasunaga et al., 2006, Mech. Dev. 123(12): 893--906 Fate map of the distal portion of Drosophila proboscis as inferred from the expression and mutations of basic patterning genes. [FBrf0194566] Show all research papers ...

Allele Dmel\Dll17

Allele Dmel\Dll¹⁷