Allele Dmel\abd-A^iab3-277

General Information
Symbol	Dmel\abd-A^iab3-277	Species	D. melanogaster
Name		FlyBase ID	FBal0000094
Feature type	allele	Created / Updated	2006-08-22/2006-08-22
Associated gene	Dmel\abd-A

Allele class	loss of function
Mutagen	X ray
Nature of the Allele
Allele class	loss of function (Karch et al., 1990)
Mutagen	X ray (Karch et al., 1985, Busturia et al., 1989)
Mapped Features and Mutations
Type Symbol & Location Additional Notes References
Associated Sequence Data
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name

UniProtKB/Swiss-Prot
UniProtKB/TrEMBL

Progenitor genotype	Abd-B^Mcp-1
Nature of the lesion	Statement Reference Lesion mapped to: 63-64.5 kb. (Karch et al., 1985) Mutation maps outside the 5' end of the transcription unit. (Macias et al., 1990)
Assay mode
Caused by aberration	Tp(3;3)iab3²⁷⁷ (Karch et al., 1985, Foronda et al., 2005)
Cytology
Phenotypic Data
Phenotypic Class
	viable (Jijakli and Ghysen, 1992) visible \| homeotic (Karch et al., 1985, Busturia et al., 1989)
Phenotype Manifest In
	adult abdominal segment 3 (Karch et al., 1985, Busturia et al., 1989) adult abdominal segment 4 (Karch et al., 1985, Busturia et al., 1989) adult abdominal segment 5 (Karch et al., 1985, Busturia et al., 1989) adult abdominal segment 6 (Karch et al., 1985) Wheeler's organ 3 (Karch et al., 1985) Wheeler's organ 4 (Karch et al., 1985) Wheeler's organ 5 (Karch et al., 1985) Wheeler's organ 6 (Karch et al., 1985) gonad \| male (Karch et al., 1985) gonad \| female (Karch et al., 1985) parasegment 8 (Sanchez-Herrero, 1991) parasegment 9 (Sanchez-Herrero, 1991) parasegment 10 (Sanchez-Herrero, 1991) parasegment 11 (Sanchez-Herrero, 1991) parasegment 12 (Sanchez-Herrero, 1991) ovary (with Df(3R)Ubx109) (Foronda et al., 2005) female genitalia (with Df(3R)Ubx109) (Foronda et al., 2005)
Detailed Description
	Statement Reference Adult abdominal segments 3-6 are transformed towards the second. The Wheeler's organ appears partially formed in segments 3-6. Individuals of both sexes lack gonads. Tp(3;3)iab3²⁷⁷ individuals show a weak abd-A^iab3-Uab4 phenotype. (Karch et al., 1985) Hemizygotes show a partial transformation of A1 to A2 and of A3-A5 to A2. (Busturia et al., 1989) Hemizygous embryos show transformed parasegments 8--12 to parasegment 7 (FBrf0042053). (Sanchez-Herrero, 1991) The internal genitalia of abd-A^iab3-277/Df(3R)Ubx109 females are either absent or highly abnormal. These flies lack ovaries. (Foronda et al., 2005)
Interactions
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement Reference
Xenogenetic Interactions
Statement Reference
Complementation & Rescue Data
Comments
Stocks ( 0 )

Notes on Origin
Discoverer	D. Baker. D. Baker.

Synonyms & Secondary IDs ( 7 )
Reported As
Symbol Synonym	abd-A^iab3-277 iab-3²⁷⁷ (Casares and Sanchez-Herrero, 1995) iab3²⁷⁷ iab-3^B277 (Jijakli and Ghysen, 1992) iab3^B277 iab3^DB Mcp^revB277
Name Synonym
Secondary FlyBase IDs

References ( 8 )
Research paper	Foronda et al., 2005, Development 133(1): 117--127 Requirement of abdominal-A and Abdominal-B in the developing genitalia of Drosophila breaks the posterior downregulation rule. [FBrf0190286] Casares and Sanchez-Herrero, 1995, Development 121(6): 1855--1866 Regulation of infraabdominal regions of the Bithorax complex of Drosophila by gap genes. [FBrf0078174] Jijakli and Ghysen, 1992, Int. J. Dev. Biol. 36(1): 93--99 Segmental determination in Drosophila central nervous system: analysis of the abdominal-A region of the Bithorax complex. [FBrf0056377] Sanchez-Herrero, 1991, Development 111: 437--449 Control of the expression of the Bithorax complex genes abdominal-A and Abdominal-B by cis-regulatory regions in Drosophila embryos. [FBrf0053795] Karch et al., 1990, Genes Dev. 4(9): 1573--1587 abdA expression in Drosophila embryos. [FBrf0051832] Macias et al., 1990, Development 110: 1197--1207 Expression and regulation of the abd-A gene of Drosophila. [FBrf0051550] Busturia et al., 1989, Development 107: 575--583 Genetic structure of the abd-A gene of Drosophila. [FBrf0049558] Karch et al., 1985, Cell 43: 81--96 The abdominal region of the Bithorax complex. [FBrf0042053]

Allele Dmel\abd-Aiab3-277

Allele Dmel\abd-A^iab3-277