A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Aberration Dmel\Df(2R)k10408

General Information
SymbolDmel\Df(2R)k10408SpeciesD. melanogaster
NameFlyBase IDFBab0028916
Feature typechromosomal_deletionCreated / Updated2006-05-14/2006-06-14
Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment
Computed Breakpoints include
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
CG4827k10408
(FlyBase, 1996-)
mthl3k10408
(Bowman, 1999.11.11)
Carries alleles
Transposon Insertions
P{lacW}mthl3k10408
(Bowman, 1999.11.11)
Genetic mapping information
Comments
hide Comments on Cytology
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
robl
(Bowman et al., 1999)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Homozygotes die as larvae. Mutants exhibit visible disc abnormalities: discs are small. Clones induced in wild type discs are abnormal: mutation affects cell proliferation so the clone size is small.
(Roch et al., 1998)
Homozygous lethal.
(Spradling et al., 1999)
The lethality of the Df(2R)k10408 chromosome is due to the deletion of the robl gene.
(Bowman et al., 1999)
hide Position Effect Variegation Data
  
hide Stocks ( 2 )
Kyoto
108308
y1 w67c23; Df(2R)k10408, P{lacW}mthl3k10408/CyO
Bloomington
5574
y1 w67c23; Df(2R)k10408, P{lacW}mthl3k10408 CG4827k10408/CyO
hide Notes on Origin
Discoverer
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      hide Synonyms & Secondary IDs ( 5 )
      Reported As
      Symbol Synonym
      Df(2R)k10408
       
      l(2)k10408
      (Bowman, 1999.11.11)
      l(2)k10408k10408
       
      roblk
      (Gunawardena et al., 2004, Bowman, 2000.3.30)
      unnamed
      (Spradling et al., 1999)
      Name Synonym
      Secondary FlyBase IDs
      • FBal0064209
      hide References ( 8 )
      Research paper
      Gunawardena et al., 2004, Neuron 40(1): 25--40
      Disruption of axonal transport by loss of huntingtin or expression of pathogenic polyQ proteins in Drosophila. [FBrf0167960]
      Bowman et al., 1999, J. Cell Biol. 146(1): 165--179
      Drosophila roadblock and Chlamydomonas LC7: a conserved family of dynein-associated proteins involved in axonal transport, flagellar motility, and mitosis. [FBrf0109386]
      Spradling et al., 1999, Genetics 153(1): 135--177
      The Berkeley Drosophila genome project gene disruption project. Single P-element insertions mutating 25% of vital Drosophila genes. [FBrf0111489]
      Roch et al., 1998, Molec. gen. Genet. 257(2): 103--112
      Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: clonal analysis and morphology of imaginal discs. [FBrf0100624]
      Personal communication to FlyBase
      Bowman, 2000.3.30, Df(2R)robl-c.
      Df(2R)robl-c. [FBrf0126814]
      Bowman, 1999.11.11, l(2)k10408.
      l(2)k10408. [FBrf0112176]
      FlyBase analysis
      FlyBase, 1996-, FlyBase inference based on genome sequence analysis.
      FlyBase inference based on genome sequence analysis. [FBrf0104946]
      Computer file
      BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project.
      Berkeley Drosophila Genome Project. [FBrf0067338]