Aberration Dmel\Df(2L)cact-255rv64

General Information
Symbol	Dmel\Df(2L)cact-255rv64	Species	D. melanogaster
Name		FlyBase ID	FBab0022223
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 hits cact << dac << bk2
Sequence coordinates
Deleted segment	35F6--36D
Duplicated segment
Computed Breakpoints include	35F6-35F12;36D
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	P{FZ}cact²⁵⁵ (Landis and Tower, 1999) cact²⁵⁵ (Tower et al., 1993)
Mutagen	Δ2-3 (Tower et al., 1993)
Class of aberration (relative to progenitor)	chromosomal_deletion (Tower et al., 1993, Ashburner et al., 1999.10.12)
Breakpoints	35F-36A;36D (Tower et al., 1993) 35F;36D (Roote, 1995.3.24, Ashburner et al., 1999.10.12)
Causes alleles	cact^chif64 (Tower, 1999.12.23, Ashburner et al., 1999.10.12, Roote, 1996.1.11)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of cact (FBrf0084572) Right limit of break 1 from inclusion of cact (FBrf0077931) Limits of break 2 from polytene analysis (FBrf0058564)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	chif (Tower et al., 1993, Dawson et al., 1995) mRpL4 (Tower et al., 1993, Dawson et al., 1995) cact (Roote, 1995.3.24, Roote, 1996.1.11) Cas (BDGP Project Members, 1994-1999, Spradling et al., 1999) glu (BDGP Project Members, 1994-1999, Spradling et al., 1999) dac (Tower et al., 1993, BDGP Project Members, 1994-1999, Roote, 1996.1.11, Roote, 1996.8, Spradling et al., 1999) l(2)k15102 (BDGP Project Members, 1994-1999, Spradling et al., 1999) l(2)k13905 (BDGP Project Members, 1994-1999, Spradling et al., 1999) bst (Boquet et al., 2000) Mhc (BDGP Project Members, 1994-1999, Spradling et al., 1999)
Partially deleted / disrupted	cact (Roote, 1996.8)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Cyp303a1 (Dawson et al., 1995) Syx5 (Dawson et al., 1995) fzy (Dawson et al., 1995, Roote, 1996.1.11, Roote, 1996.8) cact (Dawson et al., 1995) cni (Dawson et al., 1995) heix (Dawson et al., 1995) crp (BDGP Project Members, 1994-1999, Dawson et al., 1995, Spradling et al., 1999) twe (Dawson et al., 1995) vimar (BDGP Project Members, 1994-1999) l(2)k16215 (BDGP Project Members, 1994-1999) fs(2)lto1 (Roote, 1997.12.2, Ashburner et al., 1999.10.12) l(2)k07020 (BDGP Project Members, 1994-1999) l(2)k04206 (BDGP Project Members, 1994-1999, BDGP Project Members, 2000-) l(2)k09834 (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(2L)cact-255rv64 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile. (Sawamura et al., 2000) Df(2L)cact-255rv64/cort^QW55 embryos develop at 18^oC but fail to develop at 29^oC. A shift to the restrictive temperature during any stage of embryogenesis arrests embryonic development. (Lieberfarb et al., 1996) Heterozygotes show no adult central brain defect. (Boquet et al., 2000)
Position Effect Variegation Data

Stocks ( 3 )
Kyoto	103355 Df(2L)cact-255rv64 / CyO; ry⁵⁰⁶ 107408 Df(2L)cact-255rv64, cact^chif64/CyO; ry⁵⁰⁶
Bloomington	2583 Df(2L)cact-255rv64, cact^chif64/CyO; ry⁵⁰⁶
Notes on Origin
Discoverer	J. Tower. (Roote, 1995.3.24)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)cact-255rv64 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is assumed to be a false positive result (the suppressor may not be within the bounds of the deficient region) because the deficiency chromosome fails to complement lethal mutations of l(2)gl; deficiencies that are mutant for l(2)gl are often also deficient for the 2L TAS array (FBrf0137248) and it has previously been shown (FBrf0137248, FBrf0158986) that partial or complete deficiency of the 2L TAS array on the homologue suppresses silencing of brown-red variants of P{3'WP-2,w^var}2Lt. (Mason et al., 2004)
Synonyms & Secondary IDs ( 13 )
Reported As
Symbol Synonym	cact^225rv64 (Ashburner et al., 1999.10.12) Df(2)cact-255rv64 (Anderson et al., 2006) DF(2L)cact (Firth et al., 2000) Df(2L)cact255 (Ashton et al., 2001) Df(2L)cact-255rv64 Df(2L)cact-256 (LaJeunesse et al., 2001) Df(2L)cact^255rv64 (Chanut et al., 2002, Du et al., 2003) Df(2L)cat-255rv64 (Li and Li, 2003) Df(2L)chif64 (Roote, 1995.3.24, Roote, 1997.12.2, Roote, 1996.8, ) Df(2L)chif⁶⁴ (Landis and Tower, 1999, Dawson et al., 1995) Df(2L)chiffon64 (Lieberfarb et al., 1996) dfChif64 (Tower, 1999.12.23) unnamed (Tower et al., 1993)
Name Synonym
Secondary FlyBase IDs
	FBab0001755
References ( 28 )

Generate a list of	All references relating to this aberration ( 28 )

List References by type	Research paper ( 18 ) Personal communication to FlyBase ( 6 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Computer file ( 2 )
Recent research papers ( 1 )
	Anderson et al., 2006, Dev. Biol. 297(2): 536--549 Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. [FBrf0193889] Show all research papers ...