Aberration Dmel\In(1)sc^8Lsc^4R

General Information
Symbol	Dmel\In(1)sc^8Lsc^4R	Species	D. melanogaster
Name	Inversion (1) scute-8 Left scute-4 Right	FlyBase ID	FBab0004200
Feature type	inversion_derived_deficiency_plus_duplication	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data
Sequence coordinates
Deleted segment
Duplicated segment	h26--h32
Computed Breakpoints include
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	In(1)sc⁸ In(1)sc⁴
Mutagen	recombination
Class of aberration (relative to progenitor)
Breakpoints
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Deleted for 21 kb in y - sc (Carramolino et al., 1982) Breakpoint(s) molecularly mapped (Carramolino et al., 1982, Ruiz-Gomez and Ghysen, 1993)
Comments on Cytology
	Duplicated for the NO.
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	sc (del Prado and Garcia-Bellido, 1984, Alonso and Cabrera, 1988, Leyns et al., 1989, Skeath and Carroll, 1991, Martinez and Modolell, 1991, Ray and Rodrigues, 1994, Gomez-Skarmeta et al., 1995, Jimenez and Ish-Horowicz, 1997) anon-1Ba (Alonso and Cabrera, 1988)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	y (Alonso and Cabrera, 1988, Leyns et al., 1989, Ray and Rodrigues, 1994) ac (Alonso and Cabrera, 1988, Leyns et al., 1989, Ray and Rodrigues, 1994) l(1)sc (Alonso and Cabrera, 1988, Ray and Rodrigues, 1994) ase (Alonso and Cabrera, 1988, Ray and Rodrigues, 1994) Cyp4g1 (Alonso and Cabrera, 1988) pcl (Alonso and Cabrera, 1988) anon-1Bc (Alonso and Cabrera, 1988)
Molecular Data
Genes Duplicated
Complementation Data
Completely duplicated	bb
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	10-15% of hemizygous males emerge from the pupal case. The number of bristles on the proboscis is reduced to 21 +/- 2. S-type and P-type bristles are unaffected, while some M-type and L-type bristles are missing. The labial disc lacks 10 sensory mother cells that are normally generated in the first two waves of specification. (Ray and Rodrigues, 1994) Eliminates ac expression from the notal clusters from which the sc dependent bristles arise. (Skeath and Carroll, 1991) In heterozygous females the deletion acts as a dominant suppressor of emc but not of h. (del Prado and Garcia-Bellido, 1984) homozygous female lethal Male survives rarely and is extreme sc and slight ac (Garcia-Bellido, 1979). Remains immobile after hatching.
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	4482 C(1;YL)1, In(1)sc^8Lsc^4R, y^31d sc^-/Dp(1;YL)sc^S1/C(1)DX, y¹ f¹
Kyoto	101143 In(1)sc^8Lsc^4R, v¹ f¹ / In(1)dl-49, y¹ Hw¹ m² g⁴ / Dp(1;Y)y²67g19.1 102051 In(1)sc^8Lsc^4R + In(1)S w^a / C(1)DX, y¹ f¹ ; Dp(1;2)sc¹⁹ b¹ pr¹ / In(2L+2R)Cy, Cy¹ pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	50-89% of In(1)sc^8Lsc^4R/+ adults lack upper humeral bristles. (Wrischnik et al., 2003)
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	Df(1)sc^8L4R (Skeath and Carroll, 1991) Df(1)sc^8Lsc^4R (Gomez-Skarmeta et al., 1995, Martinez and Modolell, 1991, Rodriguez et al., 1990, Martin-Bermudo et al., 1993, ) Dfsc^8Lsc^4R (Alonso and Cabrera, 1988) Dp(1;1)sc^8Lsc^4R In(1)sc8^Lsc4^R In(1)sc8Lsc4R (Wrischnik et al., 2003, Deshpande et al., 1995) In(1)sc^8Lsc^4R sc8L-4R (Ray and Rodrigues, 1994) sc^8L-sc^4R (Leyns et al., 1989)
Name Synonym	Inversion (1) scute-8 Left scute-4 Right
Secondary FlyBase IDs

References ( 20 )
Research paper	Wrischnik et al., 2003, Genetics 165(4): 2007--2027 Recruitment of the proneural gene scute to the Drosophila sex-determination pathway. [FBrf0167657] Takano-Shimizu, 2000, Genetics 156(1): 269--282 Genetic screens for factors involved in the notum bristle loss of interspecific hybrids between Drosophila melanogaster and D. simulans. [FBrf0130105] Jimenez and Ish-Horowicz, 1997, Molec. Cell. Biol. 17(8): 4355--4362 A chimeric enhancer-of-split transcriptional activator drives neural development and achaete-scute expression. [FBrf0095301] Deshpande et al., 1995, Molec. Cell. Biol. 15(8): 4430--4440 scute (sis-b) function in Drosophila sex determination. [FBrf0081934] Gomez-Skarmeta et al., 1995, Genes Dev. 9(15): 1869--1882 Cis-regulation of achaete and scute: shared enhancer-like elements drive their coexpression in proneural clusters of the imaginal discs. [FBrf0083155] Ray and Rodrigues, 1994, Roux Arch. dev. Biol. 203: 340--350 The function of the proneural genes achaete and scute in the spatio-temporal patterning of the adult labellar bristles of Drosophila melanogaster. [FBrf0074258] Martin-Bermudo et al., 1993, Development 118(3): 1003--1112 Molecular characterization of the lethal of scute genetic function. [FBrf0066962] Ruiz-Gomez and Ghysen, 1993, EMBO J. 12(3): 1121--1130 The expression and role of a proneural gene, achaete, in the development of the larval nervous system of Drosophila. [FBrf0058134] Martinez and Modolell, 1991, Science 251: 1485--1487 Cross-regulatory interactions between the proneural achaete and scute genes of Drosophila. [FBrf0055064] Skeath and Carroll, 1991, Genes Dev. 5: 984--995 Regulation of achaete-scute gene expression and sensory organ pattern formation in the Drosophila wing. [FBrf0054073] Rodriguez et al., 1990, EMBO J. 9: 3583--3592 Competence to develop sensory organs is temporally and spatially regulated in Drosophila epidermal primordia. [FBrf0051652] Leyns et al., 1989, Roux Arch. dev. Biol. 198(4): 227--232 Two different sets of cis acting elements regulate scute to establish two different sensory patterns. [FBrf0050916] Alonso and Cabrera, 1988, EMBO J. 7(8): 2585--2591 The achaete-scute gene complex of Drosophila melanogaster comprises four homologous genes. [FBrf0047940] Dambly-Chaudiere and Ghysen, 1987, Genes Dev. 1(3): 297--306 Independent subpatterns of sense organs require independent genes of the achaete-scute complex in Drosophila larvae. [FBrf0046281] del Prado and Garcia-Bellido, 1984, Roux Arch. dev. Biol. 193(4): 242--245 Genetic regulation of the achaete scute complex of Drosophila melanogaster. [FBrf0041705] Carramolino et al., 1982, EMBO J. 1: 1185--1191 DNA map of mutations at the scute locus of Drosophila melanogaster. [FBrf0037903] Garcia-Bellido, 1979, Genetics 91: 491--520 Genetic analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0033191] Garcia-Bellido and Santamaria, 1978, Genetics 88: 469--486 Developmental analysis of the achaete-scute system of Drosophila melanogaster. [FBrf0031639] Sturtevant and Beadle, 1936, Genetics 21: 554--604 The relations of inversions in the X chromosome of Drosophila melanogaster to crossing over and disjunction. [FBrf0003535]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]

Aberration Dmel\In(1)sc8Lsc4R

Aberration Dmel\In(1)sc^8Lsc^4R