Aberration Dmel\Df(2R)cn83c

General Information
Symbol	Dmel\Df(2R)cn83c	Species	D. melanogaster
Name	Deficiency (2R) cinnabar	FlyBase ID	FBab0002120
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << dpld << sax << bk2
Sequence coordinates
Deleted segment	43C5--44C1
Duplicated segment
Computed Breakpoints include	43C5;44B6-44C1
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen
Class of aberration (relative to progenitor)	chromosomal_deletion (Nellen et al., 1994, Pauli et al., 1995, Duffy et al., 1996, Rodriguez et al., 1996, Harbecke and Lengyel, 1995, Landecker et al., 1994)
Breakpoints	43C5;44B6-44C1 (Nellen et al., 1994) 43C5-43D1;44B6-44C1 (Landecker et al., 1994, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996, Rodriguez et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	All limits from polytene analysis (FBrf0074016)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	sax (Nellen et al., 1994) dpld (Kimbrell, 1996.4.28, Rodriguez et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygous embryos have smaller heads than normal, and have abnormal tracheae and segmentation. The midgut is smaller than normal, does not constrict and the midgut primordia do not fuse in some embryos. The hindgut and Malpighian tubules are variable in length and crinkled. (Harbecke and Lengyel, 1995) Large ventral cord cells. (Smith et al., 1993)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	3136 Df(2R)cn83c/SM5
Kyoto	106873 Df(2R)cn83c/SM5
Notes on Origin
Discoverer
	Recovered as apparent cn double recombinants from test crosses of dysgenic-type males that were heterozygous for a maternally derived dp b cn bw second chromosome and paternally derived autosomes extracted from natural populations and capable of promoting male recombination.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2R)cn83c chromosome may act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but the eye colour phenotype in the presence of Df(2R)cn83c overlaps the eye colour phenotype in a wild-type background so it cannot be unequivocally demonstrated that the deficiency chromosome uncovers a suppressor of telomeric silencing. In addition, any suppression is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	Df3136 (Elmore and Smith, 2001) Df(2R)cn83c
Name Synonym	Deficiency (2R) cinnabar
Secondary FlyBase IDs

References ( 14 )
Research paper	Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Elmore and Smith, 2001, Insect Biochem. Molec. Biol. 31(8): 791--798 Putative Drosophila odor receptor OR43b localizes to dendrites of olfactory neurons. [FBrf0136968] Firth et al., 2000, Genetics 156(2): 733--748 Identification of genomic regions that interact with a viable allele of the Drosophila protein tyrosine phosphatase corkscrew. [FBrf0129810] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Rodriguez et al., 1996, Genetics 143(2): 929--940 Identification of immune system and responses genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster. [FBrf0087676] Harbecke and Lengyel, 1995, Roux Arch. dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo<up>D</up> mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Landecker et al., 1994, Dev. Genet. 15(5): 425--434 Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster. [FBrf0076124] Nellen et al., 1994, Cell 78(2): 225--237 Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. [FBrf0074016] Smith et al., 1993, Genetics 135(3): 817--829 Identification of genomic regions required for DNA replication during Drosophila embryogenesis. [FBrf0065574]
Personal communication to FlyBase	Kimbrell, 1996.4.28, [title not yet available] [title not yet available] [FBrf0086748]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]