A Database of Drosophila Genes & Genomes

FB2008_06, released July 3, 2008
 

Aberration Dmel\Df(2L)r10

General Information
SymbolDmel\Df(2L)r10SpeciesD. melanogaster
NameFlyBase IDFBab0001903
Feature typechromosomal_deletionCreated / Updated2006-08-22/2006-08-22
Formalized genetic data wor << bk1 << sna << dac << bk2 << her
Sequence coordinates
Deleted segment35D1--36A7
Duplicated segment
Computed Breakpoints include 35D1;36A6-36A7
Breakpoints Inherited  
hide Nature of the Aberration
Cytological Order
Progenitor
P{hsp26-lacZ}36A
 
Mutagen
γ ray
 
Class of aberration (relative to progenitor)
chromosomal_deletion
(Schupbach and Wieschaus, 1991, Kania et al., 1995, Rodriguez et al., 1996, Holmes et al., 1998)
Breakpoints
35D1-35D2;36A6-36A7
(Schupbach and Wieschaus, 1991)
35E1-35E2;36A6-36A7
(Kania et al., 1995, Rodriguez et al., 1996, Holmes et al., 1998)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
hide Comments on Cytology
Left limit of break 1 from polytene analysis (FBrf0054123) Right limit of break 1 from inclusion of sna (FBrf0051973) Limits of break 2 from polytene analysis (FBrf0054123)
 
Ref: Ashburner et al., 1990, Genetics 126: 679--694
(Kania et al., 1995)
hide Molecularly Mapped Breakpoints
 
hide Sequence Crossreferences
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
hide Gene Deletion & Duplication Data
hide Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted
sna
(Ashburner et al., 1990, Ashraf et al., 1999)
l(2)35Df
(Ashburner et al., 1990)
wek
(Ashburner et al., 1990)
Gli
(Ashburner et al., 1990, Auld et al., 1995)
l(2)35Di
(Ashburner et al., 1990)
BicC
(Ashburner et al., 1990, Schupbach and Wieschaus, 1991)
beat-Ia
(van Vactor et al., 1993, Holmes et al., 1998, Holmes and Heilig, 1999)
Cyp303a1
(Ashburner et al., 1990)
Syx5
(Ashburner et al., 1990)
fzy
(Ashburner et al., 1990, Dawson et al., 1993)
chif
(Ashburner et al., 1990, Schupbach and Wieschaus, 1991)
mRpL4
(Ashburner et al., 1990)
cact
(Ashburner et al., 1990, Schupbach and Wieschaus, 1991, Stronach and Perrimon, 2001)
cni
(Ashburner et al., 1990)
heix
(Ashburner et al., 1990, BDGP Project Members, 1994-1999, Spradling et al., 1999)
crp
(Ashburner et al., 1990, BDGP Project Members, 1994-1999, Roote, 1998.11.16, Spradling et al., 1999)
twe
(Schupbach and Wieschaus, 1991)
Ca-α1D
(Ashburner et al., 1990)
CycE
(Ashburner et al., 1990, BDGP Project Members, 1994-1999, Spradling et al., 1999)
dac
(Ashburner et al., 1990, BDGP Project Members, 1994-1999, Ashraf et al., 1999)
lace
(Ashburner et al., 1990)
l(2)35De
(Ashburner et al., 1990)
ms(2)35Eb
(Ashburner et al., 1990)
S(ls)6
(Pepple et al., 2007)
Molecular Data
hide Genes NOT Deleted / Disrupted
Complementation Data
l(2)gl
(Mason et al., 2004)
rk
(Eriksen et al., 2000)
Su(H)
(Ashburner et al., 1990)
vas
(Ashburner et al., 1990)
stc
(Zhu et al., 2005, Ashburner et al., 1990)
TfIIS
(Ashburner et al., 1990)
ck
(Ashburner et al., 1990)
esg
(Ashburner et al., 1990, Kania et al., 1995, Rodriguez et al., 1996)
wor
(Ashburner et al., 1990)
gft
(Zhu et al., 2005, Ashburner et al., 1990)
twe
(BDGP Project Members, 1994-1999)
her
(Li and Baker, 1998)
glu
(BDGP Project Members, 1994-1999, Kania et al., 1995, Spradling et al., 1999)
vimar
(BDGP Project Members, 1994-1999)
l(2)k16215
(BDGP Project Members, 1994-1999)
l(2)k15102
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(2)k13905
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
l(2)36Aa
(Ashburner et al., 1990)
l(2)k09216
(BDGP Project Members, 1994-1999)
rd
(Ashburner et al., 1990)
l(2)k09033
(BDGP Project Members, 1994-1999)
l(2)36Ac
(Ashburner et al., 1990)
l(2)35Cc
(Ashburner et al., 1990)
l(2)k17003
(BDGP Project Members, 1994-1999)
l(2)36Ab
(Ashburner et al., 1990)
plo
(Ashburner et al., 1990)
fs(2)lto1
(Roote, 1997.12.2, Ashburner et al., 1999.10.12)
l(2)36Ad
(Ashburner et al., 1990)
l(2)k04206
(BDGP Project Members, 1994-1999, BDGP Project Members, 2000-)
l(2)k09834
(BDGP Project Members, 1994-1999)
Cyt-c-d
(BDGP Project Members, 1994-1999, Spradling et al., 1999)
Molecular Data
hide Genes Duplicated
Complementation Data
Molecular Data
hide Genes NOT Duplicated
Complementation Data
Molecular Data
hide Related Comments
hide Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations
Df(2L)r10 in combination with a pair of introgressions from D.simulans spanning 30F1-31E7 to 35D7-36A14 Dsim\Int(2L)S and 21A1 to 22D1--23A2 Dsim\Int(2L)D produces sterile male flies. These flies are female sterile.
(Sawamura et al., 2000)
Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.
(Coyne et al., 1998)
Heterozygosity for Df(2L)r10 results in 14.5% X chromosome nondisjunction and 8.5% fourth chromosome nondisjunction in In(1)FM7/X ; svspa-pol females.
(Harris et al., 2003)
In embryos heterozygous for Df(2L)r10, leading edge (LE) cells are observed in a single row; however the ring of LE cells are positioned slightly more dorsally than in wild-type and appear smaller to account for the reduced area of the amnioserosa tissue.
(Stronach and Perrimon, 2001)
Midgut development of mutant embryos is wild type.
(Bilder and Scott, 1995)
No second site non-complementing phenotype with zipEbr and zipmhc-c6.1.
(Halsell and Kiehart, 1998)
Shows no maternal enhancement of dpphr4.
(Nicholls and Gelbart, 1998)
The Df(2L)r10 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,wvar}2Lt insertion).
(Mason et al., 2004)
hide Position Effect Variegation Data
  
hide Stocks ( 3 )
Bloomington
1491
Df(2L)r10, cn1/CyO
Kyoto
106710
Df(2L)r10, cn1/CyO
103272
Df(2L)r10, cn1 / CyO, Cy1 dplv1 pr1 cn2
hide Notes on Origin
Discoverer
Y. Hiromi.
 
hide Balancer / Genotype Variants of the Aberration
    hide Separable Components
      hide Other Comments
      hide Synonyms & Secondary IDs ( 5 )
      Reported As
      Symbol Synonym
      45490
      (Eriksen et al., 2000)
      Df(2)r10
      (Anderson et al., 2006)
      Df(2L)r10
      (Pepple et al., 2007, Crest et al., 2007, Zhu et al., 2005)
      DfKu801
      (Melnikova et al., 2005)
      r10
      (Ashburner et al., 1999.10.12)
      Name Synonym
      Secondary FlyBase IDs
        hide References ( 51 )
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        hide Recent research papers ( 3 )
        Crest et al., 2007, Genetics 175(2): 567--584
        Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644]
        Pepple et al., 2007, Genetics 175(1): 125--141
        A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin. [FBrf0194654]
        Anderson et al., 2006, Dev. Biol. 297(2): 536--549
        Regulation of the retinal determination gene dachshund in the embryonic head and developing eye of Drosophila. [FBrf0193889]
        Show all research papers ...