Aberration Dmel\Df(2L)pr76

General Information
Symbol	Dmel\Df(2L)pr76	Species	D. melanogaster
Name	Deficiency (2L) purple	FlyBase ID	FBab0001899
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << spi << cad << bk2
Sequence coordinates
Deleted segment	37D--38E10
Duplicated segment
Computed Breakpoints include	37D;38E5-38E10
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Ashburner et al., 1980)
Class of aberration (relative to progenitor)	chromosomal_deletion (Kania et al., 1995, Pauli et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Ashburner et al., 1980)
Breakpoints	37D;38E (Ashburner et al., 1980, Kania et al., 1995, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0034393) Left limit of break 2 from inclusion of cad (FBrf0082073) Right limit of break 2 from polytene analysis (FBrf0034393) Ref: Lindsley and Zimm, 1992 (Kania et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	scw (Harbecke and Lengyel, 1995) cad (Harbecke and Lengyel, 1995) spi (Harbecke and Lengyel, 1995)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	neb (Ohkura et al., 1997) CycE (BDGP Project Members, 1994-1999)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Deficient embryos show an uninterpretable mutant midgut phenotype. (Bilder and Scott, 1995) Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for Df(2L)pr76 results in 0.2% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	6226 Df(2L)pr76, noc^Sco/CyO
Kyoto	108687 Df(2L)pr76, noc^Sco/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)76 Df(2L)pr76 (Crest et al., 2007) Df(2L)pr⁷⁶ (Abrell et al., 2000, Ashburner et al., 1980)
Name Synonym	Deficiency (2L) purple
Secondary FlyBase IDs

References ( 18 )
Research paper	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Harris et al., 2003, Genetics 165(2): 637--652 A deficiency screen of the major autosomes identifies a gene (matrimony) that is haplo-insufficient for achiasmate segregation in Drosophila oocytes. [FBrf0167662] Tran and Berg, 2003, Development 130(25): 6273--6282 bullwinkle and shark regulate dorsal-appendage morphogenesis in Drosophila oogenesis. [FBrf0167514] Kumar et al., 2001, Dev. Biol. 240(2): 315--325 Perturbing nuclear transport in Drosophila eye imaginal discs causes specific cell adhesion and axon guidance defects. [FBrf0141476] Lee et al., 2001, Genetics 158(4): 1545--1556 A genetic screen for suppressors and enhancers of the Drosophila pan gu cell cycle kinase identifies cyclin B as a target. [FBrf0138402] Abrell et al., 2000, Chromosoma 109(5): 334--342 A modifier screen of ectopic Kruppel activity identifies autosomal Drosophila chromosomal sites and genes required for normal eye development. [FBrf0129693] Nicholls and Gelbart, 1998, Genetics 149(1): 203--215 Identification of chromosomal regions involved in decapentaplegic function in Drosophila. [FBrf0102843] Ohkura et al., 1997, J. Cell Sci. 110(8): 945--954 Mutation of a gene for a Drosophila kinesin-like protein, Klp38B, leads to failure of cytokinesis. [FBrf0093632] Duffy et al., 1996, Genetics 142(3): 839--852 Dosage-sensitive maternal modifiers of the Drosophila segmentation gene runt. [FBrf0086390] Bilder and Scott, 1995, Genetics 141(3): 1087--1100 Genomic regions required for morphogenesis of the Drosophila embryonic midgut. [FBrf0083777] Harbecke and Lengyel, 1995, Roux Arch. dev. Biol. 204(5): 308--329 Genes controlling posterior gut development in the Drosophila embryo. [FBrf0082073] Kania et al., 1995, Genetics 139(4): 1663--1678 P-element mutations affecting embryonic peripheral nervous system development in Drosophila melanogaster. [FBrf0080145] Pauli et al., 1995, Genetics 139(2): 713--732 Identification of regions interacting with ovo<up>D</up> mutations: Potential new genes involved in germline sex determination or differentiation in Drosophila melanogaster. [FBrf0080317] Pauli et al., 1995, D. I. S. 76: 107--124 Dose dependent enhancers and suppressors of ovoD2. [FBrf0082455] Ashburner et al., 1980, D. I. S. 55: 193--195 Report of New Mutants - Drosophila melanogaster. [FBrf0034393]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Computer file	BDGP Project Members, 1994-1999, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0067338]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]