Aberration Dmel\Df(2L)TW2

General Information
Symbol	Dmel\Df(2L)TW2	Species	D. melanogaster
Name	Deficiency (2L) Ted Wright	FlyBase ID	FBab0001649
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	l(2)37Dg << bk1 << l(2)37Dm << del << bk2 << crc
Sequence coordinates
Deleted segment	37D6--38E9
Duplicated segment
Computed Breakpoints include	37D6-37E1;38E6-38E9
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor	amos^Tft (Wright et al., 1976)
Mutagen	X ray (Stathakis et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Wright et al., 1976, Pauli et al., 1995)
Breakpoints	37D2-37E1;38E6-38E9 (Wright et al., 1976, Pauli et al., 1995)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from non-inclusion of l(2)37Dc (FBrf0028753) Right limit of break 1 from polytene analysis (FBrf0028752) Limits of break 2 from polytene analysis (FBrf0082455)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	swm (Wright et al., 1976, Brittnacher and Ganetzky, 1983, Gay and Contamine, 1993) scw (Nusslein-Volhard et al., 1984) fs(2)ltoPP43 (Schupbach and Wieschaus, 1991, Butler et al., 2001) vls (Schupbach and Wieschaus, 1986, Tearle and Nusslein-Volhard, 1987, Schupbach and Wieschaus, 1989, Schupbach and Wieschaus, 1991) spir (Schupbach and Wieschaus, 1991) Fs(2)Ket (Schupbach and Wieschaus, 1991, Butler et al., 2001) Hr38 (Butler et al., 2001) dia (Butler et al., 2001) cad (Butler et al., 2001) pr (Wright et al., 1976, Butler et al., 2001) spi (BDGP Project Members, 1994-1999) l(2)01528 (Butler et al., 2001) l(2)37Dk (Wright et al., 1976) l(2)38EFb (Butler et al., 2001) l(2)37Dl (Wright et al., 1976) fs(2)lto3 (Schupbach and Wieschaus, 1991) l(2)37Di (Wright et al., 1976, Brittnacher and Ganetzky, 1983) l(2)37Dm (Wright et al., 1976) Bl (Wright et al., 1976, Butler et al., 2001) fs(2)ltoRV64 (Schupbach and Wieschaus, 1991) del (Schupbach and Wieschaus, 1991) ik2 (Butler et al., 2001) vari (Butler et al., 2001)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	esc (Wright et al., 1976) amos (Wright et al., 1976) amd (Wright et al., 1976) brat (Brittnacher and Ganetzky, 1983) Ddc (Wright et al., 1976) hk (Wright et al., 1976) RanGap (Brittnacher and Ganetzky, 1983) CadN (Wright et al., 1976) crc (Wright et al., 1976) l(2)38EFd (Butler et al., 2001) l(2)37Db (Wright et al., 1976, Brittnacher and Ganetzky, 1983) lt (Wright et al., 1976) l(2)37CDa (Wright et al., 1976) l(2)37CDb (Wright et al., 1976) l(2)37De (Brittnacher and Ganetzky, 1983) l(2)37CDe (Wright et al., 1976) M(2)39F (Wright et al., 1976) l(2)37CDd (Wright et al., 1976) l(2)37CDc (Wright et al., 1976) l(2)37CDf (Wright et al., 1976) M(2)36F (Wright et al., 1976) l(2)37Dc (Wright et al., 1976, Brittnacher and Ganetzky, 1983) rdo (Wright et al., 1976)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995)
Position Effect Variegation Data

Stocks ( 3 )
Kyoto	107228 Df(2L)TW2, Tft¹ l(2)74i¹/CyO 101419 Dp(2;2)M(2)m⁺CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2L)TW2, Tft¹ l(2)74i¹
Bloomington	3780 Df(2L)TW2, amos^Tft l(2)74i¹/CyO
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Chromosome also carries amos^Tft and l(2)74i¹. (Wright et al., 1976) Complementation data suggest that l(2)37De² and l(2)37De³ complement Df(2L)TW2 whereas l(2)37De⁴ and l(2)37De⁵ fail to complement Df(2L)TW2. (Wright et al., 1976) The Df(2L)TW2 chromosome acts as a dominant weak suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	2 (Brittnacher and Ganetzky, 1983) Df(2)TW2 (Lehmann, 1988) Df(2L)2 (Wright et al., 1976, Wright et al., 1976, Nusslein-Volhard et al., 1984, ) Df(2L)TW2 (Crest et al., 2007, Kuranaga et al., 2006, Wu et al., 2007) Df(2R)TW2 (Wolfgang and Forte, 1995)
Name Synonym	Deficiency (2L) Ted Wright
Secondary FlyBase IDs

References ( 31 )

Generate a list of	All references relating to this aberration ( 31 )

List References by type	Research paper ( 26 ) Abstract ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 3 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Wu et al., 2007, Development 134(5): 999--1009 Drosophila Varicose, a member of a new subgroup of basolateral MAGUKs, is required for septate junctions and tracheal morphogenesis. [FBrf0194079] Kuranaga et al., 2006, Cell 126(3): 583--596 Drosophila IKK-related kinase regulates nonapoptotic function of caspases, via degradation of IAPs. [FBrf0194448] Show all research papers ...