Aberration Dmel\Df(2L)E55

General Information
Symbol	Dmel\Df(2L)E55	Species	D. melanogaster
Name		FlyBase ID	FBab0001458
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	γTub37C << bk1 << l(2)37Da << fs(2)lto3 << bk2 << Lar
Sequence coordinates
Deleted segment	37D2--38A1
Duplicated segment
Computed Breakpoints include	37D2;38A1
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	ethyl methanesulfonate (Wright et al., 1976, Wright et al., 1981, Stathakis et al., 1995)
Class of aberration (relative to progenitor)	chromosomal_deletion (Wright et al., 1976, Wright et al., 1981, Pauli et al., 1995, Stathakis et al., 1995, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pentz et al., 1990)
Breakpoints	37D2-37E1;37F5-38A1 (Wright et al., 1976, Pentz et al., 1990, Pauli et al., 1995, Harbecke and Lengyel, 1995, Duffy et al., 1996) 37D2-37E1;35F5-38A1 (Wright et al., 1981) 37C6-37D1;37F5-38A1 (Stathakis et al., 1995)
Causes alleles	Lar^E55 (Wills et al., 1999, Desai et al., 1997, Krueger et al., 1996)
Carries alleles
Transposon Insertions
Genetic mapping information
Comments	Breakpoint(s) molecularly mapped (Rutledge et al., 1992)
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0028752) Right limit of break 1 from inclusion of l(2)37Da (citation unavailable) Left limit of break 2 from inclusion of Lar (FBrf0086508) Right limit of break 2 from polytene analysis (FBrf0028752) Ref: FBrf0028752. (Stathakis et al., 1995)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	RanGap (Brittnacher and Ganetzky, 1983) tj (Li et al., 2003) swm (Brittnacher and Ganetzky, 1983, Gay and Contamine, 1993) Lar (Krueger et al., 1996, Desai et al., 1997) ref(2)P (Wyers et al., 1995) spi (Tearle and Nusslein-Volhard, 1987, Jones and McGinnis, 1993, BDGP Project Members, 1994-1999, Tio et al., 1994, Harbecke and Lengyel, 1995) l(2)37Db (Brittnacher and Ganetzky, 1983) l(2)37Ea (Butler et al., 2001) fs(2)lto3 (Schupbach and Wieschaus, 1991) l(2)37De (Brittnacher and Ganetzky, 1983) l(2)37Di (Brittnacher and Ganetzky, 1983) fs(2)ltoRV64 (Schupbach and Wieschaus, 1991) l(2)37Fc (Butler et al., 2001) l(2)37Dc (Brittnacher and Ganetzky, 1983)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	esc (Wright et al., 1976) amos (Wright et al., 1976) Catsup (Stathakis et al., 1995) Dox-A2 (Stathakis et al., 1995) amd (Wright et al., 1976, Stathakis et al., 1995) brat (Brittnacher and Ganetzky, 1983, Stathakis et al., 1995) l(2)37Cc (Stathakis et al., 1995) Ddc (Wright et al., 1976, Stathakis et al., 1995) Lim3 (Stathakis et al., 1995) l(2)37Bb (Stathakis et al., 1995) hk (Wright et al., 1976, Stathakis et al., 1995) γTub37C (Stathakis et al., 1995) scw (Tearle and Nusslein-Volhard, 1987, Jones and McGinnis, 1993) fs(2)ltoPP43 (Butler et al., 2001) neb (Ohkura et al., 1997) Fs(2)Ket (Butler et al., 2001) pr (Wright et al., 1976) CadN (Wright et al., 1976) crc (Wright et al., 1976) lt (Wright et al., 1976) tyr1 (Pentz et al., 1990) Low (Bhadra et al., 1997) l(2)37Fg (Jones and McGinnis, 1993) cub (Stathakis et al., 1995) l(2)37Fe (Jones and McGinnis, 1993) M(2)39F (Wright et al., 1976) Bl (Wright et al., 1976) M(2)36F (Wright et al., 1976) hkl (Stathakis et al., 1995) mib2 (Stathakis et al., 1995) Aats-asn (Stathakis et al., 1995) l(2)37Cb (Stathakis et al., 1995) l(2)37Cd (Stathakis et al., 1995) l(2)37Ce (Stathakis et al., 1995) l(2)37Cg (Stathakis et al., 1995) rdo (Wright et al., 1976)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Dominantly causes tergite defects in less than 50% of run³ heterozygotes. (Duffy et al., 1996) Heterozygosity for Df(2L)E55 results in 3.5% X chromosome nondisjunction and 2.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females. (Harris et al., 2003) Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2. (Pauli et al., 1995) Homozygous embryos do not always complete head involution. (Harbecke and Lengyel, 1995) Midgut development of mutant embryos is wild type. (Bilder and Scott, 1995) Shows no maternal enhancement of dpp^hr4. (Nicholls and Gelbart, 1998) The central nervous system (CNS) is narrower than normal and the commissures are thicker than normal and incompletely separated in Df(2L)E55 embryos. (Dong and Jacobs, 1997)
Position Effect Variegation Data

Stocks ( 3 )
Bloomington	3076 Df(2L)E55, rdo¹ hk¹ Lar^E55 pr¹/CyO
Kyoto	106822 Df(2L)E55, rdo¹ hk¹ Lar^E55 pr¹/CyO 103230 CyO, Cy¹ dp^lv1 pr¹ cn² / Df(2L)E55, rdo¹ hk¹ pr¹
Notes on Origin
Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	The Df(2L)E55 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion), but this is a false positive result (the suppressor is not within the bounds of the deficient region) because the region of the deficiency is covered by one or more nonsuppressing deficiencies. (Mason et al., 2004)
Synonyms & Secondary IDs ( 4 )
Reported As
Symbol Synonym	Df(2L)E55 (Crest et al., 2007, Kamimura et al., 2006) Df(2L)TWE55 (Wyers et al., 1995) Df(3L)E55 (Wills et al., 1999) E55 (Brittnacher and Ganetzky, 1983)
Name Synonym
Secondary FlyBase IDs

References ( 42 )

Generate a list of	All references relating to this aberration ( 42 )

List References by type	Research paper ( 37 ) Personal communication to FlyBase ( 1 ) FlyBase analysis ( 1 ) Stock list ( 1 ) Computer file ( 1 ) Book ( 1 )
Recent research papers ( 2 )
	Crest et al., 2007, Genetics 175(2): 567--584 Onset of the DNA replication checkpoint in the early Drosophila embryo. [FBrf0194644] Kamimura et al., 2006, J. Cell Biol. 174(6): 773--778 Specific and flexible roles of heparan sulfate modifications in Drosophila FGF signaling. [FBrf0193661] Show all research papers ...