Aberration Dmel\Df(2L)A400

General Information
Symbol	Dmel\Df(2L)A400	Species	D. melanogaster
Name	Deficiency (2L) Aaron	FlyBase ID	FBab0001413
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	Pgant35A << bk1 << elB << stc << bk2 << rd
Sequence coordinates
Deleted segment	35A1--35C3
Duplicated segment
Computed Breakpoints include	35A1-35A4;35C1-35C3
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	X ray (Ashburner, 1982, Fossett et al., 1994)
Class of aberration (relative to progenitor)	chromosomal_deletion (Gubb et al., 1990, Roote et al., 1996)
Breakpoints	35A1-35A4;35B10 (Gubb et al., 1990, Roote et al., 1996)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Left limit of break 1 from polytene analysis (FBrf0051930) Right limit of break 1 from inclusion of elB (FBrf0051916) Left limit of break 2 from inclusion of TfIIS (FBrf0073088) Right limit of break 2 from non-inclusion of esg (FBrf0073088) Adhr status unknown. (Roote, 2002.1.15)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	elB (Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) ppk (Ainsley et al., 2003) noc (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) dyn-p25 (Ashburner et al., 1982, Ashburner, 1982) l(2)35Bd (Ashburner et al., 1982, Ashburner, 1982) Su(H) (Ashburner et al., 1982, Ashburner, 1982) stc (Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994, Roote et al., 1996) TfIIS (Fossett et al., 1994) ck (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) l(2)35Bg (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982) osp (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996) Adh (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994, Roote et al., 1996) l(2)35Bc (Ashburner et al., 1982, Ashburner, 1982) elA (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Davis et al., 1997) pu (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Roote et al., 1996, Davis et al., 1997) l(2)35Be (Ashburner et al., 1982, Ashburner, 1982) mol (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994, Roote et al., 1996)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	Sos (Ashburner et al., 1982) RpII33 (Ashburner et al., 1982, Fossett et al., 1994) Ance (Ashburner et al., 1982, Fossett et al., 1994) Sop2 (Ashburner et al., 1982) tam (Ashburner et al., 1982) nimC3 (Ashburner et al., 1982, Fossett et al., 1994) rk (Ashburner et al., 1982, Fossett et al., 1994) wb (Ashburner et al., 1982, Fossett et al., 1994) Pgant35A (Ashburner et al., 1982, Ashburner et al., 1982, Davis et al., 1990, Fossett et al., 1994, Roote et al., 1996, Flores and Engels, 1999) stc (Ashburner et al., 1982) esg (Fossett et al., 1994) sna (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) wor (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) gft (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) wek (Fossett et al., 1994) mRpL4 (Fossett et al., 1994) Ca-α1D (Fossett et al., 1994) CycE (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) kuz (Fossett et al., 1994) DNApol-γ35 (Ashburner et al., 1982) b (Ashburner et al., 1982) lace (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982, Fossett et al., 1994) l(2)34Fd (Ashburner et al., 1982, Davis et al., 1990, Roote et al., 1996) l(2)35De (Fossett et al., 1994) rd (Ashburner et al., 1982, Ashburner et al., 1982, Ashburner, 1982) j (Ashburner et al., 1982) l(2)34Fc (Ashburner et al., 1982, Ashburner et al., 1982, Fossett et al., 1994, Roote et al., 1996) l(2)34Db (Ashburner et al., 1982, Fossett et al., 1994) l(2)35Cc (Fossett et al., 1994) ms(2)34Fe (Davis et al., 1990, Roote et al., 1996)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Chromosome acts as a weak trans-suppressor of a physical interaction between tandemly duplicated copies of w⁺, an interaction that is required for the suppression of genes by z¹. (Gubb et al., 1990) The Df(2L)A400 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3\'WP-2,w^var}2Lt insertion). (Mason et al., 2004)
Position Effect Variegation Data

Stocks ( 2 )
Bloomington	6266 T(2;3;4)CA4, Df(2L)A400, b¹ cn¹ bw¹/CyO, Adh^nB
Kyoto	108708 T(2;3;4)CA4, Df(2L)A400, b¹ cn¹ bw¹/CyO, Adh^nB
Notes on Origin
Discoverer	Aaron.
	selected as ADH null on 1-penten-3-ol. Induced with, but genetically separable from T(2;3;4)CA4.
Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments
	Chromosome also carries T(2;3;4)CA4. (Ashburner et al., 1982) Reported to delete Adhr in error; see FBrf0141768 for correction. (Roote et al., 1996)
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	A400 (Fossett et al., 1994) Df(2L)A400
Name Synonym	Deficiency (2L) Aaron
Secondary FlyBase IDs

References ( 19 )
Research paper	Mason et al., 2004, Genetics 168(3): 1353--1370 A deficiency screen for dominant suppressors of telomeric silencing in Drosophila. [FBrf0180277] Ainsley et al., 2003, Curr. Biol. 13(17): 1557--1563 Enhanced locomotion caused by loss of the Drosophila DEG/ENaC protein Pickpocket1. [FBrf0162002] Ashburner et al., 1999, Genetics 153(1): 179--219 An exploration of the sequence of a 2.9-Mb region of the genome of Drosophila melanogaster. The Adh region. [FBrf0111326] Flores and Engels, 1999, Proc. Natl. Acad. Sci. USA 96(6): 2964--2969 Microsatellite instability in Drosophila spellchecker1 (MutS homolog) mutants. [FBrf0108178] Davis et al., 1997, Hereditas 126(1): 67--75 Genetic and phenotypic analysis of the genes of the elbow-no-ocelli region of chromosome 2L of Drosophila melanogaster. [FBrf0093413] Roote et al., 1996, D. I. S. 77: 55--65 Aberrations in the l(2)34Fc - l(2)35Bb region of chromosome arm 2L. [FBrf0091422] Fossett et al., 1994, Mutat. Res. 307(1): 213--222 The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. [FBrf0073088] Ashburner et al., 1990, Genetics 126: 679--694 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0051973] Davis et al., 1990, Genetics 126: 105--119 The molecular analysis of the el-noc complex of Drosophila melanogaster. [FBrf0051916] Gubb et al., 1990, Genetics 126: 167--176 A novel transvection phenomenon affecting the white gene of Drosophila melanogaster. [FBrf0051930] Ashburner et al., 1983, Genetics 104: 405--431 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. [FBrf0039455] Ashburner et al., 1982, Genetics 102: 421--435 The genetics of a small autosomal region of Drosophila melanogaster, including the structural gene for alcohol dehydrogenase. [FBrf0038050] Ashburner, 1982, Genetics 101: 447--459 The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038053] Ashburner et al., 1982, Genetics 102: 401--420 The genetics of a small chromosome region of Drosophila melanogaster containing the structural gene for Alcohol dehydrogenase. [FBrf0038047] Aaron, 1979, Mutat. Res. 63: 127--137 X-ray-induced mutations affecting the level of the enzyme alcohol dehydrogenase in Drosophila melanogaster: frequency and genetic analysis of null-enzyme mutants. [FBrf0033674]
Personal communication to FlyBase	Roote, 2002.1.15, Adhr status unknown. Adhr status unknown. [FBrf0141768] Davis, 2001.4.23, FlyBase error report for CG15284 and CG3474 on Mon Apr 23 02:12:23 2001. FlyBase error report for CG15284 and CG3474 on Mon Apr 23 02:12:23 2001. [FBrf0138570]
FlyBase analysis	FlyBase, 2007, En masse symbol-based assigment of Aberration Class with respect to wild type. En masse symbol-based assigment of Aberration Class with respect to wild type. [FBrf0191808]
Book	Lindsley and Zimm, 1992, The Genome of Drosophila melanogaster. The Genome of Drosophila melanogaster. [FBrf0066905]