Aberration Dmel\Df(1)svr

General Information
Symbol	Dmel\Df(1)svr	Species	D. melanogaster
Name	Deficiency (1) silver	FlyBase ID	FBab0000974
Feature type	chromosomal_deletion	Created / Updated	2006-08-22/2006-08-22

Formalized genetic data	bk1 << l(1)1Aj << RpL36 << bk2 << su(s)
Sequence coordinates
Deleted segment	1A1--1B13
Duplicated segment
Computed Breakpoints include	1A1;1B13
Breakpoints Inherited
Nature of the Aberration
Cytological Order
Progenitor
Mutagen	cold-treatment (California Institute of Technology, 1940) spontaneous (Eeken and Sobels, 1990)
Class of aberration (relative to progenitor)	chromosomal_deletion (Voelker et al., 1989, Prudhommeau and Proust, 1990, Watson et al., 1991, Duffy et al., 1996, Sherald and Voelker, 1985, Harbecke and Lengyel, 1995, Park and Yamamoto, 1993, Eeken and Sobels, 1990, Sutton, 1943)
Breakpoints	1A1;1B9-1B10 (Sutton, 1943, Eeken and Sobels, 1990, Harbecke and Lengyel, 1995, Duffy et al., 1996) XLt;1B10-1B13 (Sherald and Voelker, 1985, Voelker et al., 1989, Prudhommeau and Proust, 1990, Watson et al., 1991) XLt;1B9-1B10 (Park and Yamamoto, 1993)
Causes alleles
Carries alleles
Transposon Insertions
Genetic mapping information
Comments
Comments on Cytology
	Limits of break 1 from polytene analysis (FBrf0005951) Left limit of break 2 from inclusion of l(1)1Bi (FBrf0086390) Right limit of break 2 from polytene analysis (FBrf0042241) Deletion of 16/17 bands. (Eeken and Sobels, 1990) Right break is to the right of 1B9--1B10. (California Institute of Technology, 1940)
Molecularly Mapped Breakpoints

Sequence Crossreferences
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
Gene Deletion & Duplication Data
Genes Deleted / Disrupted
Complementation Data
Completely deleted / disrupted	cin (Kramers et al., 1983, Kramers et al., 1991) y (Sutton, 1943, Kramers et al., 1983, Kramers et al., 1991, California Institute of Technology, 1940) ac (Sutton, 1943, Kramers et al., 1983, Kramers et al., 1991, California Institute of Technology, 1940, Bate et al., 1993) sc (Sutton, 1943, Kramers et al., 1983, Kramers et al., 1991, Lai and Mackay, 1993, Park and Yamamoto, 1993, California Institute of Technology, 1940, Bate et al., 1993) Exp6 (Kramers et al., 1983, Kramers et al., 1991) vnd (Kramers et al., 1983, Corbin et al., 1991, Kramers et al., 1991, Bate et al., 1993, Harbecke and Lengyel, 1995) l(1)1Bi (Duffy et al., 1996) RpL36 (Duffy et al., 1996) svr (Sutton, 1943, Kramers et al., 1983, Kramers et al., 1991, Park and Yamamoto, 1993, California Institute of Technology, 1940) ewg (Kramers et al., 1983, Kramers et al., 1991) elav (Kramers et al., 1983, Corbin et al., 1991, Kramers et al., 1991, Bate et al., 1993) skpA (Khush et al., 2002, Murphy, 2003) l(1)1Ac (Kramers et al., 1983, Kramers et al., 1991) l(1)1Ad (Kramers et al., 1983, Kramers et al., 1991) l(1)1Aj (Kramers et al., 1991) l(1)1Ai (Kramers et al., 1983) l(1)1Bc (Kramers et al., 1983, Kramers et al., 1991)
Molecular Data
Genes NOT Deleted / Disrupted
Complementation Data
	l(1)1Bi (Kramers et al., 1983) su(s) (Voelker et al., 1989, California Institute of Technology, 1940) br (Kramers et al., 1991) dor (Kramers et al., 1991) sta (California Institute of Technology, 1940) arm (Wieschaus et al., 1984) l(1)1Bk (Kramers et al., 1983) l(1)1Fg (Kramers et al., 1991) brc (Kramers et al., 1983, Kramers et al., 1991) l(1)1Fc (Kramers et al., 1991) l(1)1Ec (Kramers et al., 1991) l(1)1Eg (Kramers et al., 1991) l(1)1Fh (Kramers et al., 1991) l(1)1Da (Kramers et al., 1983) tw (Kramers et al., 1983, Kramers et al., 1991)
Molecular Data
Genes Duplicated
Complementation Data
Molecular Data
Genes NOT Duplicated
Complementation Data
Molecular Data
Related Comments

Phenotypic Data
In combination with other aberrations
NOT in combination with other aberrations	Df(1)svr/N^55e11 mutants show substantial rescue of both the cuticular and muscle phenotypes of N^55e11 embryos. The cuticle has expanded both in the anteroposterior and in the dorsoventral axes, although there is still no sign of denticle belts. Muscle phenotype shows many of the fibres are oriented and attached in a clearly patterned fashion. At the ventral margins of the cuticular shield the muscles appear disorganised with unfused fibres. (Bate et al., 1993) Acts as a dosage sensitive maternal modifier of run: causes tergite defects in greater than 65% of run³ heterozygotes. Shows a dominant Minute phenotype: short fine bristles, delayed development and reduced viability. (Duffy et al., 1996) All es and most of the nd neurons are removed, ch neurons are not affected. Neurons are more disorganized in the ventral region. (Dambly-Chaudiere and Ghysen, 1987) Embryonic lethal abnormal development of nervous system and cell lethal (Ripoll and Garcia-Bellido). Embryos show missing elements in the CNS pattern. (Corbin et al., 1991) Females heterozygous for Df(1)N19 that are derived from da^unspecified/+ mothers show reduced viability at 29^oC. (Sanchez et al., 1994) Flies show frequent absence of the postvertical, orbital and abdominal bristles. (California Institute of Technology, 1940) Hemizygous embryos were examined with polarised light microscopy and antibody staining: muscle pattern incomplete due to muscle absences and detachments. (Drysdale et al., 1993) Heterozygous females exhibit reduced viability and fertility. (Eeken and Sobels, 1990) Lethal in homozygous and hemizygous condition. (Sutton, 1943) Mutant embryos have about 72 cells in each Malpighian tubule cell (as opposed to about 125 in wild-type). The addition of btl::Egfr^{Scer\UAS.T:λ\cI-DD} has no effect on the Df(1)svr Malpighian tubule phenotype. (Sudarsan et al., 2002)
Position Effect Variegation Data

Stocks ( 4 )
Bloomington	1028 Df(1)svr, N^spl-1/C(1)DX, y¹ f¹; Dp(1;f)101 901 Df(1)svr, N^spl-1 ras² fw¹/Dp(1;Y)y²67g19.1/C(1)DX, y¹ f¹
Kyoto	106175 Df(1)svr, N^spl-1/C(1)DX, y¹ f¹; Dp(1;f)101 106108 Df(1)svr, N^spl-1 ras² fw¹/Dp(1;Y)y²67g19.1/C(1)DX, y¹ f¹
Notes on Origin
Discoverer	L.V. Morgan. L.V. Morgan, 31st Oct. 1939 (California Institute of Technology, 1940)

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	Df(1)svr Df(1)svrLVM (Sutton, 1943) Dfsvr (Kramers et al., 1991, Bate, 1993) svr (Sanchez et al., 1994)
Name Synonym	Deficiency (1) silver Deficiency(1)silver L. V. Morgan (Sutton, 1943)
Secondary FlyBase IDs

References ( 36 )

Generate a list of	All references relating to this aberration ( 36 )

List References by type	Research paper ( 32 ) Review ( 2 ) FlyBase analysis ( 1 ) Book ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2006 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2006 Show reviews ...