Drosophila Genes

Drosophila genes listed by biochemical function

Hox (Homeobox) transcription factors A - D || E - N || O - Z

abdominal A

homeodomain - Antennapedia class

Abdominal B

homeodomain - bithorax complex

achintya

homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Vismay, for spermatogenesis

Antennapedia

homeodomain - Antennapedia class

apterous

homeodomain - lim domain

araucan

homeodomain Pbx class

aristaless

homeodomain - paired-like

Arrowhead

LIM domains and LIM homeodomain

bagpipe

homeodomain - NK-2 class

BarH1 & BarH2

homeodomain

bicoid

homeodomain

buttonless

homeodomain

caudal

homeodomain

caupolican

homeodomain Pbx class

C15 (common alternative name Clawless)

member of the 93E cluster of homeodomain proteins - regulates spatial patterning of the tarsus, a distal portion of the leg -

homolog of vertebrate oncogene Hox11

cut

homeodomain - cut domain

defective proventriculus

homeodomain

Deformed

homeodomain - Antennapedia class

Distal-less

homeodomain

drifter (preferred name: ventral veinless)

homeodomain - pou domain

empty spiracles

homeodomain

engrailed

homeodomain - engrailed class - segment polarity gene

even-skipped

homeodomain - pair rule gene

extradenticle

homeodomain - Pbx class

extra-extra

a homeodomain transcription factor - regulates motorneuron cell fate by restricting expression of Even-skipped and Lim2

eyegone

homeodomain & paired domain (paired box)

eyeless

homeodomain & paired domain (paired box)

fushi tarazu

homeodomain - Antennapedia class - pair rule gene

gooseberry-proximal (common alternative name: gooseberry-neuro)

homeodomain - paired domain (paired box)

gooseberry-distal (common alternative name: gooseberry)

homeodomain - paired domain (paired box)

Goosecoid

homeodomain - paired-like

homothorax

homeodomain - HM domain

intermediate neuroblasts defective

homeodomain protein

invected

homeodomain - engrailed class

Ipou (preferred name: Abnormal chemosensory jump 6)

homeodomain and POU domain

islet (preferred name: tailup)

homeodomain and LIM domain

labial

homeodomain - Antennapedia class

ladybird early and ladybird late

transcription factors - homeodomain proteins

Lim1

Lim domain and lim homeodomain

mirror

homeodomain - Pbx class

muscle segment homeobox-1

homeodomain

muscle segment homeobox 2 (preferred name: tinman)

homeodomain - NK-2 class

NK1 (common alternative name: S59)

homeodomain - NK-1 class

NK2 (preferred name: ventral nervous system defective)

homeodomain - NK2 class

Nkx6 (alternative name: HGTX)

homeobox, NK decapeptide domain transcription factor - acts within a subclass of early born neurons to link

neuronal subtype identity to neuronal morphology and connectivity

onecut

homeodomain and cut domain

Optix

homeodomain and Six domain

orthodenticle

homeodomain - paired-like

paired

homeodomain - paired domain (paired box)

POU domain protein 1 (common alternative name: pdm-1)

homeodomain - pou domain

POU domain protein 2 (common alternative name: pdm-2)

homeodomain - pou domain

proboscipedia

homeodomain - Antennapedia class

prospero

novel homeodomain

PvuII-PstI homology 13

homeodomain transcription expressed in the developing eye - required for rhabdomere morphogenesis and proper detection of light

reversed polarity

homeodomain

rough

homeodomain

homeodomain transcription factor - required for regulation of genes involved in brain morphogenesis

s59 (preferred name: NK1)

homeodomain - NK-1 class

Sex combs reduced

homeodomain - Antennapedia class

shaven (common alternative name: sparkling)

paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog

sine oculis

homeodomain

sparkling (preferred name: shaven)

paired domain and homeodomain (partial) - Pax2, 5 and 8 homolog

tailup (common alternative name: islet)

homeodomain and LIM domain

tinman (common alternative name: NK-4 and msh-2)

homeodomain - NK-2 class

Ultrabithorax

homeodomain - Antennapedia class

unplugged

homeodomain protein

ventral nervous system defective (common alternative name: vnd or NK2)

homeodomain - NK-2 class

ventral veinless (common alternative name: drifter)

homeodomain - pou domain

vismay

homeodomain transcription factor (TGIF subclass) - required, along with homeodomain protein Achintya, for spermatogenesis

zerknüllt

homeodomain - Antennapedia class - DV polarity

Zn finger homeodomain 1

zinc finger domain and homeodomain protein - mutation results in various degrees of local errors in mesodermal cell fate or positioning

Zn finger homeodomain 2

transcription factor - zinc finger domain and homeodomain - required for correct proximal wing development

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Drosophila genes listed by biochemical function

Please e-mail comments/corrections to brodyt@codon.nih.gov